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Dietary glutamine,glutamate,and aspartate supplementation improves hepatic lipid metabolism in post-weaning piglets

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Animal Nutrition 2020年第2期6卷 124-129页

作者： Ming Qi Jing Wanga Bi'e Tan Jianjun Li Simeng Liao Yanhong Liu Yulong Yin Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China University of Chinese Academy of Sciences Beijing 100008China Department of Animal Science University of CaliforniaDavis 95616CAUSA

A previous study has demonstrated that early weaning significantly suppressed hepatic glucose metabolism in ***(Glu),aspartate(Asp)and glutamine(Gln)are major metabolic fuels for the small intestine and can alleviate weaning stress,and therefore might improve hepatic energy *** objective of this study was to investigate the effects of administration of Glu,Asp and Gln on the expression of hepatic genes and proteins involved in lipid metabolism in post-weaning ***-six weaned piglets were assigned to the following treatments:control diet(Control;basal diet+15.90 g/kg alanine);Asp,Gln and Glu-supplemented diet(Control+AA;basal diet+1.00 g/kg Asp+5.00 g/kg Glu+10.00 g/kg Gln);and the energy-restricted diet supplemented with Asp,Gln and Glu(Energy^-+AA;energy deficient diet+1.00 g/kg Asp+5.00 g/kg Glu+10.00 g/kg Gln),Liver samples were obtained on d 5 and 21 *** fed Energy^-+AA diet had higher liver mRNA abundances of acyl-CoA oxidase 1(ACOX1),succinate dehydrogenase(SDH),mitochondrial transcription factor A(TFAM)and sirtuin 1(SIRT1),as well as higher protein expression of serine/threonine protein kinase 11(LKB1),phosphor-acetyl-CoA carboxylase(P-ACC)and SIRT1 compared with piglets fed control diet(Phepatic lipid metabolism to some extent,which may provide nutritional intervention for the insufficient energy intake after weaning in piglets.

关键词： Glutamate Aspartate Glutamine Post-weaning piglets hepatic lipid metabolism

Effects of Bacillus subtilis on hepatic lipid metabolism and oxidative shess response in grass carp(Ctenopharyngodon idellus)fed a high-fat diet

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Marine Life Science & Technology 2020年第1期2卷 50-59页

作者： Hui Zhao Yan'er Luo Yongan Zhang Xiaoxuan Chen Hui Wang Daoyuan Guo Zhixin Wu College of Fisheries Huazhong Agricultural UniversityWuhan 430070China Hubei Engineering Technology Research Center for Aquatic Animal Disease Control and Prevention Wuhan 430070China Key Laboratory of Freshwater Animal Breeding Ministry of AgricultureWuhan 430070China Hubei Provincial Engineering Laboratory for Pond Aquaculture Wuhan 430070China

Bacillus subtilis is widely used in aquaculture as a ***,few studies have been conducted to examine the effect of *** on liver lipid metabolism.A total of 135 healthy grass carp(50.24±1.38 g)were randomly divided into three groups:control(Con),high-fat diet(HF),and high-fat diet+***(***),and fed for 8 *** results showed that compared with the HF group,the weight gain rate(WGR)significantly increased(Pc0.05)and the hepatic lipid content,serum low-density lipoprotein cholesterol(LDL-C),and aspartate aminotransferase(AST)decreased in the group supplemented with ***(Phepatic mRNA expression of fatty acid synthase(FAS)was significantly down-regulated and the carnitine palmitoyl transferases(CPTlala)were up-regulated in the HF+*** group compared to the HF group(Phepatic lipid content by inhibiting its synthesis and promoting p-oxidation of fatty *** may also alleviate dyslipidaemia and prevent oxidative damage in the liver caused by the high-fat diet of grass ***,dietary supplementation with *** shows promise as a therapeutic or preventive tool against fatty liver disease.

关键词： Bacillus subtilis Grass carp Growth performance hepatic lipid metabolism Oxidative stress

A nonalcoholic fatty liver disease cirrhosis model in gerbil:the dynamic relationship between hepatic lipid metabolism and cirrhosis

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A nonalcoholic fatty liver disease cirrhosis model in gerbil...

New insight into inter-organ crosstalk contributing to the pathogenesis of non- alcoholic fatty liver disease （NAFLD）

第十五届中国实验动物科学年会

作者： Wei Li Zheng Guan Jean C Brisset Qiaojuan Shi Qi Lou Yue Ma Su Suriguga Huazhong Ying Xiaoying Sa Zhenwen Chen Wim J Quax Xiaofeng Chu Laboratory Animal Center Zhejiang University Laboratory Animal Center Zhejiang Academy of Medical Sciences Departments of Chemical and Pharmaceutical Biology GUIDEUniversity of Groningen Department of Radiology New York University Departments of Pharmaceutical Technology and Biopharmacy GUIDEUniversity of Groningen Department of Laboratory Animal Science School of Basic Medical ScienceCapital Medical University

Nonalcoholic fatty liver disease(NAFLD) usually takes decades to develop into cirrhosis,which limits the longitudinal study of *** work aims at developing a NAFLD-caused cirrhosis model in gerbil and examining the dynamic relationship between hepatic lipid metabolism and *** fed gerbil a high-fat and high-cholesterol diet(HFHCD) for 24 weeks,and recorded the gerbil’s phenotype at 3,6,9,12,15,18,21,24 *** model’s pathological process,lipid metabolism,oxidative stress,liver collagen deposition and presence of relevant cytokines were tested and evaluated during the full-time frame of disease *** gerbil model can induce non-alcoholic steatohepatitis(NASH) within 9 weeks,and can develop cirrhosis after 21 weeks *** model’s lipids metabolism disorder is accompanied with the liver damage *** the NAFLD progression,triglycerides(TG) and free fatty acids(FFA) have presented distinct rise and fall tendency,and the turning points are at the fibrosis *** that,the ratios of total cholesterol(CHO) to high-density lipoprotein cholesterol(HDL-C) exhibited constant growth tendency,and have a good linear relationship with HSC(R2 = 0.802,P lipids metabolism and *** compelling rise and fall tendency of TG and FFA indicated that the fibrosis progression can lead to impairment in lipoprotein synthesis and engender decreased TG ***/HDL-C ratios can imply the fibrosis progress and be used as a blood indicator for disease prediction and prevention.

关键词： Cirrhosis fibrosis hepatic lipid metabolism nonalcoholic fatty liver disease(NAFLD) gerbil

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Protein & Cell 2018年第2期9卷 164-177页

作者： Xu Zhang Xuetao Ji Qian Wang John Zhong Li Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Nanjing Medical University Nanjing 211166 China Jiangsu Province Key Laboratory of Human Functional Genomics Nanjing Medical University Nanjing 211166 China

Non-alcoholic fatty liver disease （NAFLD） is the most common cause of chronic liver dysfunction and a sig- nificant global health problem with substantial rise in prevalence over the last decades. It is becoming increasingly clear that NALFD is not only predominantly a hepatic manifestation of metabolic syndrome, but also involves extra-hepatic organs and regulatory pathways. Therapeutic options are limited for the treatment of NAFLD. Accordingly, a better understanding of the pathogenesis of NAFLD is critical for gaining new insight into the regulatory network of NAFLD and for identifying new targets for the prevention and treatment of NAFLD. In this review, we emphasize on the current understanding of the inter-organ crosstalk between the liver and peripheral organs that contributing to the pathogenesis of NAFLD.

关键词： non-alcoholic fatty liver disease hepatic lipid metabolism hypothalamus gut-liver axis adipose tissue

Interaction between stress responses and circadian metabolism in metabolic disease

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Liver Research 2017年第3期1卷 156-162页

作者： Zhao Yang Hyunbae Kim Arushana Ali Ze Zheng Kezhong Zhang Center for Molecular Medicine and Genetics Wayne State University School of MedicineMIUSA Department of Microbiology Immunologyand BiochemistryWayne State University School of MedicineMIUSA Karmanos Cancer Institute Wayne State University School of MedicineDetroitMIUSA

Circadian rhythms play crucial roles in orchestrating diverse physiological processes that are critical for health and *** circadian rhythms are closely associated with various human metabolic diseases,including type 2 diabetes,cardiovascular disease,and non-alcoholic fatty liver *** lifestyles are frequently associated with an irregular circadian rhythm,which poses a significant risk to public *** the central clock has a set periodicity,circadian oscillators in peripheral organs,particularly in the liver,can be entrained by metabolic alterations or stress *** the molecular level,the signal transduction pathways that mediate stress responses interact with the key determinants of circadian oscillation to maintain metabolic homeostasis under physiological or pathological *** the liver,a number of nuclear receptors or transcriptional regulators,which are regulated by metabolites,hormones,the circadian clock,or environmental stressors,serve as direct links between stress responses and circadian *** this review,we summarize recent advances in the understanding of the interactions between stress responses(endoplasmic reticulum stress response,oxidative stress response,and inflammatory responses)and circadian metabolism,and the role of these interactions in the development of metabolic diseases.

关键词： Stress response Circadian metabolism Metabolic disease Non-alcoholic fatty liver disease(NAFLD) hepatic lipid metabolism

The Action of p-Synephrine on lipid metabolism in the Perfused Rat Liver

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Journal of Biosciences and Medicines 2017年第5期5卷 8-21页

作者： Juliany Fontoura da Silva-Pereira Andrea Luiza de Oliveira Valoto Livia Bracht Geferson de Almeida Goncalves Rosane Marina Peralta Adelar Bracht Department of Biochemistry University of MaringaMaringaBrazil Faculdade Integrado Campo MouraoBrazil

p-synephrine and p-octopamine were found to increase lipolysis in adipocytes. The present study approaches the question if these compounds, natural products of the bitter orange (Citrus aurantium fruit), increase lipolysis and fatty acid oxidation in the liver. Experiments were done in the perfused rat liver. Non-recirculating hemoglobin-free perfusion was done using the Krebs/ Henseleit-bicarbonate buffer (pH 7.4) as perfusion fluid. Both p-synephrine and p-octopamine, at the concentrations of 100 μM, were found to stimulate the hepatic triacylglycerol lipase by 40% and 51%, respectively. These seem to be the maximal stimulations possible in the liver. In the perfused liver, p-synephrine, when present at an initial concentration of 500 μM, was able to increase the non-esterified fatty acid release after one hour of recirculating perfusion. The effects of p-synephrine on the oxidation of exogenously supplied [1-14C]octanoate and [1-14C]oleate were minimal. Only oxygen uptake, already stimulated by octanoate or oleate, was additionally increased by the infusion of p-synephrine. These results contrast with those obtained in a previous study with p-octopamine, which increased the production of 14CO2 from both [1-14C]octanoate and [1-14C]oleate. Apparently only the oxidation of endogenous fatty acids is stimulated by p-synephrine. On the other hand, both p-synephrine and p-octopamine stimulate the hepatic triacylglycerol lipase to a much lesser extent than the adipocyte lipase. It can be concluded that p-synephrine affects much more carbohydrate metabolism in the liver than lipid metabolism.

关键词： hepatic lipid metabolism Lipolysis Fatty Acid Release Fatty Acid Oxidation