Effects of Bacillus subtilis on hepatic lipid metabolism and oxidative shess response in grass carp(Ctenopharyngodon idellus)fed a high-fat diet

作     者：Hui Zhao Yan'er Luo Yongan Zhang Xiaoxuan Chen Hui Wang Daoyuan Guo Zhixin Wu Hui Zhao;Yan'er Luo;Yongan Zhang;Xiaoxuan Chen;Hui Wang;Daoyuan Guo;Zhixin Wu

作者机构：College of FisheriesHuazhong Agricultural UniversityWuhan 430070China Hubei Engineering Technology Research Center for Aquatic Animal Disease Control and PreventionWuhan 430070China Key Laboratory of Freshwater Animal BreedingMinistry of AgricultureWuhan 430070China Hubei Provincial Engineering Laboratory for Pond AquacultureWuhan 430070China 

出 版 物：《Marine Life Science & Technology》 (海洋生命科学与技术（英文）)

年 卷 期：2020年第2卷第1期

页      面：50-59页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 0908[农学-水产] 070703[理学-海洋生物学] 07[理学] 0707[理学-海洋科学] 0836[工学-生物工程] 0713[理学-生态学] 

基　　金：the National Natural Science Foundation of China(Grant nos.31472310 and 31672683) the Technical Innovation Project of Hubei Province(Grant No.2018ABA103) 

主　　题：Bacillus subtilis Grass carp Growth performance Hepatic lipid metabolism Oxidative stress 

摘      要：Bacillus subtilis is widely used in aquaculture as a ***,few studies have been conducted to examine the effect of *** on liver lipid metabolism.A total of 135 healthy grass carp(50.24±1.38 g)were randomly divided into three groups:control(Con),high-fat diet(HF),and high-fat diet+***(***),and fed for 8 *** results showed that compared with the HF group,the weight gain rate(WGR)significantly increased(Pc0.05)and the hepatic lipid content,serum low-density lipoprotein cholesterol(LDL-C),and aspartate aminotransferase(AST)decreased in the group supplemented with ***(P0.05).Moreover,the hepatic mRNA expression of fatty acid synthase(FAS)was significantly down-regulated and the carnitine palmitoyl transferases(CPTlala)were up-regulated in the HF+*** group compared to the HF group(P0.05),***,in the HF+*** group,glutathione(GSH)significantly increased(Pv 0.()5),while hydrogen peroxide(H2O2)and malondialdehyde(MDA)contents significantly decreased compared to the HF group(P v0.05).*** may reduce the hepatic lipid content by inhibiting its synthesis and promoting p-oxidation of fatty *** may also alleviate dyslipidaemia and prevent oxidative damage in the liver caused by the high-fat diet of grass ***,dietary supplementation with *** shows promise as a therapeutic or preventive tool against fatty liver disease.