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Chinese Chemical Letters 2022年第2期33卷 703-713页

作者： Bingxin Wu Fanglin Du Wenjing A Guofeng Li Xing Wang State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical Technology Beijing100029China

Graphene-based sponge is a novel hemostatic material prepared by chemical cross-link of graphene oxide. It has a fast fluid absorption capacity to quickly absorb blood from wounds, activate clotting pathways, and achieve rapid hemostasis. In addition, graphene-based sponge is also a good platform *** can be prepared by organic cross-linking, compounding with inorganic clay, and adding bioactive factors to enhance coagulation stimulation. By these methods, the hemostatic performance of the sponge is further improved, which shows great potential for application in the field of trauma hemostasis. This article reviews the research progress of graphene-based sponges from three different preparation strategies(organic cross-linking, inorganic compounding and adding bioactive factor), summarizes their hemostatic mechanisms, and prospects the development of graphene-based hemostatic sponges.

关键词： Graphene hemostatic sponge Composite materials Synergistic effect Coagulation stimulation

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Emerging hemostatic materials for non-compressible hemorrhage control

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National Science Review 2022年第11期9卷 223-239页

作者： Ruonan Dong Hualei Zhang Baolin Guo State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology Xi'an Jiaotong University Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University

Non-compressible hemorrhage control is a big challenge in both civilian life and the battlefield, causing a majority of deaths among all traumatic injury mortalities. Unexpected non-compressible bleeding not only happens in pre-hospital situations but also leads to a high risk of death during surgical processes throughout in-hospital treatment. hemostatic materials for pre-hospital treatment or surgical procedures for non-compressible hemorrhage control have drawn more and more attention in recent years and several commercialized products have been developed. However, these products have all shown non-negligible limitations and researchers are focusing on developing more effective hemostatic materials for non-compressible hemorrhage control. Different hemostatic strategies(physical, chemical and biological)have been proposed and different forms(sponges/foams, sealants/adhesives, microparticles/powders and platelet mimics) of hemostatic materials have been developed based on these strategies. A summary of the requirements, state-of-the-art studies and commercial products of non-compressible hemorrhage-control materials is provided in this review with particular attention on the advantages and limitations of their emerging forms, to give a clear understanding of the progress that has been made in this area and the promising directions for future generations.

关键词： non-compressible hemorrhage control commercialized hemorrhage-control strategies hemostatic sponge hydrogel microparticle platelet mimics

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A nonmulberry silk fibroin-based robust mandruka for rapid hemostasis treatment

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Frontiers of Materials Science 2023年第4期17卷 147-157页

作者： Hao Zhang Siyuan Luo Weili Yang Qisheng Luo Perumal Ramesh Kannan Yao Li Xiangdong Kong Institute of Smart Biomedical Materials School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China

Uncontrolled hemorrhage resulting from traumas causes severe health *** is an urgent need for expeditious hemostatic materials to treat bleeding ***,we developed a natural protein-based hemostatic sponge extracted from nonmulberry cocoons that exhibited rapid coagulation and effective *** first built a degumming and dissolution system suitable for the Dictyoploca japonica cocoons to obtain regenerated silk fibroin(DSF).The DSF was then combined with carboxymethyl chitosan(CMCS)by glutaraldehyde(GA)crosslinking to ensure the structural stability of *** resulting DSF–CMCS–GA exhibited remarkable hemostatic properties,displaying the highest absorption *** also demonstrated comparable efficacy to commercial hemostatic *** blood-clotting index and hemolysis test showed that the prepared sponge possessed hemostatic activity and good *** with mulberry silk fibroin hemostatic sponges(SF–CMCS–GA),DSF–CMCS–GA showed slightly better effects,making them a potential alternative to mulberry *** conclusion,our study introduces the use of Dictyoploca japonica silk fibroin for hemostasis,highlighting the exploitation of wild silkworm resources and providing an excellent silk fibroin-based hemostatic sealant for acute accident wounds and biomedical applications involving massive hemorrhage.

关键词： nonmulberry silk fibroin Dictyoploca japonica regenerated silk fibroin hemostatic sponge

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