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Effect of modified Taohongsiwu decoction on patients with chemotherapy-induced hand-foot syndrome

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Journal of Traditional Chinese Medicine 2014年第1期34卷 10-14页

作者： Changlin Zhao Jia Chen Bin Yu Xianlin Wu Congqi Dai Chang Zhou Xiaoyin Chen Department of Traditional Chinese Medicine School of MedicineJinan University Oncology Department Clifford Hospital of Guangzhou University of Chinese Medicine

OBJECTIVE:To observe the effect of the Traditional Chinese Medicine,modified Taohongsiwu decoction,versus pyridoxine on patients with hand-foot syndrome(HFS)from capecitabine,sorafenib,and gefitinib chemotherapy for gastric,lung,breast,colon,or rectal ***,to compare quality of life of patients in each ***:Patients were assigned randomly to group A or *** A was given modifiedTaohongsiwu decoction to soak hands and feet for 30 min,once *** B was given 100 mg pyridoxine orally,twice *** a 2-week treatment,thetherapeutic effect was assessed by observing three major symptoms,including pain,ulceration,and muscular *** was assessed with the HFS-14 ***:Significant differences were observed between the two groups in pain relief,and improvement of daily life,walking,and interpersonal communication(P<0.01).No significant differences in driving ability or interpersonal relationships were *** 2 weeks,the effective rate was 88.3%in group A,which was significantly higher than the50%in group B(P=0.00).CONCLUSION:Modified Taohongsiwu decoction is effective in the treatment of patients with *** improves patients'quality of life according to the HFS-14.

关键词： Neoplasms hand-foot syndrome Mod-ifiedTaohongsiwu decoction Quality of life

Utility of cooling patches to prevent hand-foot syndrome caused by pegylated liposomal doxorubicin in breast cancer patients

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World Journal of Clinical Cases 2021年第33期9卷 10075-10087页

作者： Yan-Fu Zheng Xin Fu Xiao-Xu Wang Xiao-Jing Sun Xiao-Dan He Department of Breast Oncology Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042Liaoning ProvinceChina Department of Gynecology Cancer Hospital of China Medical University(Liaoning Cancer Hospital and Institute)Shenyang 110042Liaoning ProvinceChina

BACKGROUND Pegylated liposomal doxorubicin(PLD)uses the hydrophilic layer of liposomes to reach the sweat on the skin surface or accumulate in the sweat glands,producing toxic free radicals and oxidative damage,resulting in hand-foot syndrome(HFS).Regional cooling can induce vasoconstriction to reduce the release of drugs in the limbs and reduce the accumulation of drugs in sweat glands;thus,decreasing the incidence and severity of *** To study the efficacy of cooling patches to prevent HFS caused by PLD in the *** This is a retrospective cohort *** breast cancer patients(n=101)who were treated with PLD in two breast wards at our department from February 2020 to February 2021 were enrolled in the study and were randomly divided into the cooling group(51 patients)and the control group(50 patients).Patients in the control group only received routine care,while the patients in the cooling group applied cooling patches,based on routine care,to the palm and back of the hands 15 min before chemotherapy infusion for 10 *** patients took a corresponding dose of dexamethasone orally one day before chemotherapy,on the day of chemotherapy,and one day after ***23.0 version was used to analyze the data in this *** occurrence and severity of HFS was analyzed by the Mann-Whitney U test,and scores were analyzed by the Student’s t test or Wilcoxon rank-sum test.A P value<0.05 was regarded as statistically *** In this study,neither group of patients developed Grade 3 *** the control group,the incidence of Grade 1 HFS and Grade 2 HFS was 38%and 2%,***,in the cooling group,only one person developed Grade 1 HFS(2%),and none of the patients developed Grade 2 *** findings showed that cooling patches can effectively reduce the frequency and severity of HFS(P<0.0001)in the *** the fourth chemotherapy cycle,although general self-efficacy scale scores in the cooling group were low,they we

关键词： The cooling patch hand-foot syndrome Pegylated liposomal doxorubicin Breast cancer Self efficacy Quality of life

Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer

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Cancer Communications 2019年第1期39卷 514-525页

作者： Shaoyan Lin Jian Yue Xiuwen Guan Peng Yuan Jiayu Wang Yang Luo Ying Fan Ruigang Cai Qiao Li Shanshan Chen Pin Zhang Qing Li Fei Ma Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeNo.17Panjiayuan NanliChaoyang DistrictBeijing 100021P.R.China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021P.R.China

Background:Breast cancer is a global problem,and a large number of new cases are diagnosed every ***-abine is effective in patients with metastatic breast cancer(MBC).hand-foot syndrome(HFS)is a common adverse effect of *** this study,we investigated the association between single nucleotide polymorphisms(SNPs)in genes involved in capecitabine metabolism pathways and capecitabine-induced HFS in Chinese patients with MBC to identify some predictive genetic ***:We selected 3 genes involved in capecitabine metabolism and screened genetic variants in these target *** genotyped a total of 22 SNPs in the thymidylate synthase gene(TYMS),the methylene tetrahydrofolate reductase gene(MTHFR),and the ribonucleotide reductase M1 gene(RRM1)in 342 MBC patients treated with capecit-abine-based *** genotype distributions of each SNP in patients with and without HFS were assessed using Pearson’sχ^(2)test,and the relationship between HFS and genotypes of SNPs was determined using logistic regression *** association between SNPs and their corresponding gene expression was analyzed using the Blood expression quantitative trait loci(eQTL)browser online ***:We found 4 positive sites for HFS in the TYMS and MTHFR genes:TYMS rs2606241(P=0.022),TYMS rs2853741(P=0.019),MTHFR rs3737964(P=0.029),and MTHFR rs4846048(P=0.030).Logistic regression analyses showed that the genotype AG of MTHFR rs3737964[odds ratio(OR)=0.54,95%confidence interval(CI)0.31-0.97,P=0.038]and MTHFR rs4846048(OR=0.54,95%CI 0.30-0.98,P=0.042)were protective factors of HFS,whereas the genotype CT of TYMS rs2853741(OR=2.25,95%CI 1.31-3.87,P=0.012)increased the risk of *** association between the genotype GT of TYMS rs2606241(OR=1.27,95%CI 0.73-2.23,P=0.012)and HFS was *** eQTL analyses confirmed that the alleles of rs3737964 and rs4846048 affected the gene expression levels of MTHFR in ***:We have identified four potentiall

关键词： Capecitabine Polymorphism Metastatic breast cancer hand-foot syndrome TYMS MTHFR

hand-foot syndrome in a Patient with Metastatic Lung Adenocarcinoma Induced by High-Dose Icotinib:a case report and literature review

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Hand-Foot Syndrome in a Patient with Metastatic Lung Adenoca...

Chemotherapy-induced hand-foot syndrome in rectal cancer treated with acupuncture

首届浙赣两省肿瘤研究交流会

作者： Yulong Zheng Weijia Fang Nong Xu Department of Medical Oncology the First Affiliated HospitalSchool of MedicineZhejiang University

Icotinib is a new oral epidermal growth factor tyrosine kinase inhibitor(EGFR-TKI).The most frequent sideeffects of icotinib include rash and ***-foot syndrome(HFS) induced by EGFR-TKI is *** present study describes,for the first time,HFS induced by high dose icotinib in a 65-year old female with metastatic lung *** patient developed HFS during the first week of icotinib treatment with characteristic clinical *** regressed after icotinib dose-reduction was *** may occur with icotinib,especially when administered in high doses.

关键词： hand-foot syndrome epidermal growth factor kinase inhibitor adverse drug reactions

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World Journal of Acupuncture-Moxibustion 2018年第3期28卷 151-155,I0001页

作者： Fang-fei LI Hong CHEN Guo-sen LI Oncology Department of Traditional Chinese Medicine Chongqing Tumor Institute Chongqing 400030 China 0 China

Objective： To observe the clinical therapeutic effects of acupuncture on chemotherapy-induced hand-foot syndrome（HFS）.Methods： A total of 60 patients treated with chemotherapy of capecitabine and suffering from the chemotherapy-induced HFS were divided into an acupuncture group and a Vitamin B6 group according to the random number table, 30 cases in each one. In the acupuncture group, after chemotherapy,acupuncture was given at Bǎihui（百会 GV 20）, Hégǔ（合谷 LI 4）, Wàiguān（外关 TE 5）, Zúsānlǐ（足三里ST 36） and Ashi points. The needles were retained for 30 min in each treatment, once a day, totally for 2 weeks. In the Vitamin B6 group, after chemotherapy, Vitamin B6 was taken orally, 300 mg a day, totally for 2 weeks. Separately, on the day of enrollment and after 2 weeks of treatment, the scores of Karnofsky performance scale（KPS） and the quality of life（QLQ-C30） were evaluated in the acupuncture group and the Vitamin B6 group. After 2 weeks of treatment, the therapeutic effects were ***： The effective rate of chemotherapy-induced HFS was 70.0% in the acupuncture group and was36.7% in the Vitamin B6 group. The result in the acupuncture group was higher than the Vitamin B6 group, indicating the significant difference（P0.05）. After treatment, the KPS scores（84.23 ± 10.49） in the acupuncture group were higher obviously than the Vitamin B6 group（77.84 ± 10.33）, indicating the significant difference（P0.05）. Regarding QLQ-C30 evaluation, after 2-week treatment, the scores in the items of physical function, role function, emotional function, cognitive function and social function were all reduced remarkably as compared with those before treatment in the two groups, indicating the significant differences（all P〈0.05）. After treatment, the scores of physical function（7.13 ± 1.56 vs 16.72 ± 4.29）,emotional function（4.89 ± 0.87 vs 11.76 ± 1.29） and cognitive function（6.32 ± 1.23 vs 18.17 ± 4.1） in the acupuncture group were all lower obviously than those in the Vitamin B6 gr

关键词： Chemotherapy hand-foot syndrome Capecitabine Acupuncture

Pazopanib Induced hand-foot syndrome in a Patient Previously Treated with Sunitinib: A Possible Cumulative Skin Toxicity?

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Pharmacology & Pharmacy 2016年第8期7卷 354-357页

作者： Emanuele Cozzani Sanja Javor Stefano Ottoboni Aurora Parodi Department of Endocrinological and Metabolic Sciences Section of Dermatology University of Genoa Genoa Italy Department of Chirurgic and Diagnostic Sciences (DISC) University of Genoa Genoa Italy

hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia, is a skin toxicity that could be observed during target therapies such as with tyrosine-kinase inhibitors (TKI). It usually develops within the first 2 - 4 weeks of drug administration. We present a case of HFS induced by Pazopanib after 2 months of treatment, in patients previously treated with Sunitinib, suggesting a possible cumulative toxicity of two drugs. The clinical and therapeutic management of skin adverse reactions during TKI therapy usually requires 25% dose reduction and adequate local treatment. It is important for the clinicians to recognize clinical signs and symptoms of such skin toxicities. Attention should be paid especially when two or more drugs from the same class are used in combined treatment.

关键词： hand-foot syndrome Pazopanib Sunitinib Tyrosine-Kinase Inhibitors Cumulative Toxicity 1.

Stevens-Johnson syndrome and concurrent hand foot syndrome during treatment with capecitabine:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4279-4284页

作者： Ha Rim Ahn Sang-Kyung Lee Hyun Jo Youn Seok-Kweon Yun Il-Jae Lee Division of Breast and Thyroid Surgery Department of SurgeryJeonbuk National UniversityJeonju 54907South Korea Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital Jeonju 54907South Korea Department of Dermatology Jeonbuk National University Medical SchoolJeonju 54907South Korea

BACKGROUND Capecitabine is used in combination with lapatinib as palliative treatment for human epidermal growth factor receptor 2-positive metastatic breast *** most frequently reported adverse events attributed to capecitabine include diarrhea,hyperbilirubinemia,and hand-foot syndrome(HFS).A number of cutaneous adverse events have been attributed to capecitabine,including Stevens-Johnson syndrome(SJS)as a rare and potentially life-threatening mucocutaneous *** report the first case involving concurrent SJS and HFS after capecitabine and lapatinib *** SUMMARY A 70-year-old woman with a history of breast cancer treatment visited our hospital for evaluation of painful skin *** weeks earlier,she had been prescribed capecitabine plus lapatinib as treatment for metastatic breast *** subsequently developed worsening erythema and bullae on her palms and soles,as well as reddish macules on her back and chest *** evaluation of the chest wall lesions revealed extensive eosinophilic epidermal necrosis and separation of the epidermis from the *** capecitabine plus lapatinib treatment was discontinued immediately and treatment was started using systemic *** treatment resolved most lesions,although the lesions on her palms and soles required Vaseline gauze dressings,which resulted in ***,we determined that the patient had concurrent SJS and *** the dermatological problems resolved,the patient ultimately died because of multiple organ *** Oral capecitabine treatment carries a risk of both HFS and also life-threatening adverse cutaneous drug reactions,such as SJS.

关键词： Stevens-Johnson syndrome hand-foot syndrome Palliative treatment Capecitabine Breast neoplasms Case report

Evaluation of the Preventive Effect of Regional Cooling Nursing on hand foot syndrome Caused by Doxorubicin Hydrochloride Liposome

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Open Journal of Nursing 2022年第11期12卷 772-781页

作者： Yue Li Wanwei Huang Lijuan Zhang Lijun Jiang Xiaohong Lin Haiting Wu Yuting Huang Na Li Department of Nursing Sun Yat-Sen University Cancer Center Guangzhou China

Purpose: To explore the preventive effect of Regional cooling comprehensive nursing on hand foot syndrome caused by pegylated liposomal doxorubicin (PLD). Method: Adopt overall sampling method. Patients who used the same adjuvant drugs from January to December 2020 were randomly divided into an intervention group and a control group. The patients in the two groups received routine nursing guidance and drug prevention for the use of amygdalin. The patients in the intervention group were required to take protective measures of Regional cooling during chemotherapy. The occurrence of hand foot syndrome during adriamycin liposome administration was compared between the two groups. Results: By comparing the adverse reactions of cases during Adriamycin Administration, the incidence rates of grade I, II and III hand foot syndrome in the control group were 28.8%, 7.6% and 27.5% respectively, and the incidence rates of grade I, II and III hand foot syndrome in the intervention group were 42.1%, 12.3% and 7.0% respectively, with statistical significance (P Conclusion: Regional cooling nursing and preventive behavior guidance can effectively reduce the severity of hand foot syndrome caused by adriamycin.

关键词： hand-foot syndrome Regional Cooling Pegylated Liposomal Doxorubicin

Relationship between Self-Care and hand foot syndrome Specific Quality of Life in Cancer Patients

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Open Journal of Nursing 2016年第2期6卷 100-109页

作者： Naoko Mikoshiba Noriko Yamamoto-Mitani Kazuki Sato Yukari Yaju Mitsunori Miyashita Department of Adult Nursing/Palliative Care Nursing Graduate School of Medicine The University of Tokyo Tokyo Japan Department of Palliative Nursing Health Sciences Tohoku University Graduate School of Medicine Sendai Japan Department of Nursing St Luke’s International University Tokyo Japan

Purpose: The purpose of this study was to describe adherence to self-care for hand-foot syndrome (HFS) and the relationship between self-care and health-related quality of life (QOL). Methods: A cross-sectional study was conducted on 105 consecutive outpatients with HFS. To assess self-care for HFS and QOL, the participants were asked to complete self-care and HFS-14 (hand-foot syndrome specific QOL) questionnaires, respectively. Multiple regression models were used to identify the relationship between self-care and QOL. Results: Adherence to self-care for HFS was low, less than 50% for most of the items. Multivariate analysis revealed that poorer self-care (βs = -0.19;P = 0.03), depressive symptoms (βs = 0.43;P βs = 0.20;P = 0.04) were independent predictors of poorer QOL scores. Conclusions: We have identified a need for further research to develop effective programs of self-care in HFS.

关键词： Chemotherapy hand-foot syndrome Neoplasm Quality of Life Supportive Care