Hand-Foot Syndrome in a Patient with Metastatic Lung Adenocarcinoma Induced by High-Dose Icotinib:a case report and literature review
作者单位：Department of Medical Oncologythe First Affiliated HospitalSchool of MedicineZhejiang University
会议名称：《首届浙赣两省肿瘤研究交流会》
会议日期：2012年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：hand-foot syndrome epidermal growth factor kinase inhibitor adverse drug reactions
摘 要：Icotinib is a new oral epidermal growth factor tyrosine kinase inhibitor(EGFR-TKI).The most frequent sideeffects of icotinib include rash and ***-foot syndrome(HFS) induced by EGFR-TKI is *** present study describes,for the first time,HFS induced by high dose icotinib in a 65-year old female with metastatic lung *** patient developed HFS during the first week of icotinib treatment with characteristic clinical *** regressed after icotinib dose-reduction was *** may occur with icotinib,especially when administered in high doses.