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Self-Reported hair loss Following COVID-19: An Observational Study

International Journal of Dermatology and Venereology 2023年第1期6卷 29-34页

作者： Abdulmajeed Alajlan Rema Aldihan Lyan Almana Rahaf Althnayan Hadeel Awartani Sami Alsuwaidan Department of Dermatology College of MedicineKing Saud UniversityMedical CityRiyadh 12372Saudi Arabia College of Medicine King Saud UniversityMedical CityRiyadh 12372Saudi Arabia

Objective: COVID-19 has been significantly associated with both psychosocial stress and physiologic stress, both of which are known to trigger telogen effluvium. This study was performed to estimate the prevalence of hair loss among patients with COVID-19 and to determine the correlation of the severity of COVID-19 with the severity of hair ***: Data were collected through a self-administered electronic questionnaire that was distributed among social media platforms. Participants were invited to complete the survey using a convenience sampling technique. A multiple response dichotomies analysis and chi-square test of independence were used to analyze ***: Among 420 participants who reported a positive PCR result of SARS-CoV-2, 77.6% reported hair loss after COVID-19 development. Notably, the onset of hair loss was within 3 weeks of COVID-19 development in 29% of participants. Most of the participants reported that the duration of hair loss was up to 6 months, and hair regrowth was noticed within 1 year after COVID-19 development. Patients who were admitted to the hospital, who experienced respiratory difficulties, who had lost weight due to COVID-19, and who experienced symptoms for longer than 10 days were significantly more prone to experience severe hair loss following COVID-19 (P hair loss after the development of COVID-19. Interestingly, even patients with mild COVID-19 symptoms were significantly more prone to experience moderate hair loss. Unique to COVID-19 infection, the onset of hair loss following the development of COVID-19 was within 3 weeks in one-third of the participants.

关键词： telogen effluvium COVID-19 SARS-CoV-2 hair loss

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Isolation and Identification of Fungi That Cause hair loss (Alopecia)

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Advances in Bioscience and Biotechnology 2023年第7期14卷 337-345页

作者： Mohammed Mousa Atta Falah Abdulhassan Hussein College of Medicine University of Sumer Al-Rifai Iraq

Due to the crowded number of female students in a very narrow place, the fact that the college is for females only, and the fact that some of the female students live in the internal sections of the student residence, as well as the crowded number there, and as a result of the presence of the head covering or what is known as the Islamic veil on the head, which covers the hair of the head, which provides a suitable hot humid atmosphere 100% of fungal growth in the scalp of female students. Therefore, it is necessary to know the widespread fungal species that contaminate the scalp. In other research, we learn about the antifungals that should be used to reduce fungal infections in college employees. The study was carried out to identify the presence and spread of fungi that cause hair loss. The study was conducted on some students of the College of Education for Girls/University of Shatra for the period from 1/11/2021 to 1/12/2021, where 100 hundred hair samples were collected from (the scalp) from different ages in different educational stages, as random samples were taken after asking the student whether she suffers from hair loss or not, and studying the presence and spread of fungi in terms of density and type, after transferring them to the microbiology laboratory-College of Education for Girls using sterile sample collection bags. The current results showed that the fungal species E. flocculosum is the most common among them, followed by the fungal species C. carrionii, then the rest of the genera are as follows: E. flocculosum, Basisdioplus, Aspergillus terreud Hormderndrum Rhodotorula, Bipolaris, Aspergillus, Phoma, Rhizopus, Blastomyces, Microsporum, Sporothrix, Exophiala jeanselmei, Neoscytalidium Aeremonium Cladophialophora carrionii, Paecilomyces, Exophiala dermatitidis, Geotrichum, Volvariella, Rhizomucor, Saksmaea vassiformis, Candida albicans, Chrysosporium, Dimiatum.

关键词： Fungi hair loss Female Students Shatra

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Autozygosity Mapping by Genome-wide Single Nucleotide Polymorphism Array Identifies a Novel Homozygous HR Mutation in a Consanguineous Family with Universal Hereditary hair loss

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International Journal of Dermatology and Venereology 2021年第2期4卷 82-85页

作者： Sirous Zeinali Leila Youssefian Hassan Vahidnezhad Amir Hossein Saeidian Soheila Sotoudeh Hamideh Bagherian Jouni Uitto Department of Molecular Medicine Biotechnology Research CenterPasteur Institute of IranTehranIran Kawsar Human Genetics Research Center TehranIran Department of Dermatology and Cutaneous Biology Sidney Kimmel Medical Collegeand Jefferson Institute of Molecular MedicineThomas Jefferson UniversityPhiladelphiaPA 19107USA Department of Medical Genetics School of MedicineTehran University of Medical SciencesTehranIran Department of Dermatology Children’s Medical CenterCenter of ExcellenceTehran University of Medical SciencesTehranIran

Objective:Isolated hereditary hypotrichosis is caused by mutations in as many as 11 different *** conventional mutation detection strategy consists of sequencing of individual candidate genes separately,a time consuming and costly *** this study,we perform genome-wide single nucleotide polymorphism(SNP)array to identify candidate genes of hereditary ***:A consanguineous family with two patients with hereditary hypotrichosis was enrolled,and autozygosity mapping by genome-wide SNP array was utilized to identify candidate ***:Autozygosity mapping delineated runs of homozygosity,and alignment of the 11 genes identified the hairless(HR)gene as the candidate *** sequencing revealed a novel homozygous mutation c.381delT,***:This study illustrates how autozygosity mapping by a high-density SNP array streamlines mutation detection in heritable skin diseases.

关键词： familial hypotrichosis hair loss homozygosity mapping mutation detection hairless gene mutations

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Comprehensive Overview and Treatment Update on hair loss

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第3期3卷 1-8页

作者： Katlein Franca Thiago Saldanha Rodrigues Jennifer Ledon Jessica Savas Anna Chacon Department of Dermatology&Cutaneous Surgery University of Miami Miller School of MedicineMiamiUSA Department of Oncologic Surgery Instituto do Cacner Doutor Arnaldo Vieira de CarvalhoSao PauloBrazil

hair loss is one of the most common complaints among all patients consulting a dermatologist and is usually associated with severe psychological disturbances, distress and symptoms of depression. [1-3]. It can be temporary or long lasting. Diagnosis of hair loss is based on detailed clinical history, physical exam, clinical diagnostic tests, laboratory testing, and scalp biopsy, which may be necessary to confirm some diagnoses. This article presents an overview of the most common clinical causes of hair loss and provides updated information on the current available therapeutic options for these disorders.

关键词： hair loss Alopecia Telogen Effluvium Trichotillomania

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hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel^(■):double-blind, placebo-controlled trial

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Food Science and Human Wellness 2023年第5期12卷 1917-1923页

作者： Chia-Hua Liang Yung-Hsiang Lin Yung-Kai Lin Chi-Fu Chiang Department of Cosmetic Science and Institute of Cosmetic Science Chia Nan University of Pharmacy and ScienceTainan 71710China Research&Design Center TCI CO.Ltd.Taipei 114722China Institute of Food Safety and Risk Management Department of Food ScienceTaiwan Ocean UniversityKeelung 202301China Graduate Institute of Biomedical Engineering Chung Hsing UniversityTaichung 202301China

Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The banana flower extract(HappyAngel^(■))was used to treat human hair follicle dermal papilla cells(HFDPCs)and the expression of reactive oxygen species(ROS), dihydrotestosterone(DHT), and hair-related genes(SRD5A1, SRD5A2, AR, and KROX20)were monitored. Fifty subjects were divided into a placebo group and a banana flower group. The experimental group consumed banana flower extract daily for twelve weeks and then underwent hair testing, hair-related genes analysis, collection of hair loss, and questionnaires. The results showed that the banana flower extract significantly increased hair cell growth and decreased the expression of ROS, DHT, and hair follicle growth inhibition-related SRD5A1, SRD5A2, and AR genes, and significantly increased the expression of hair growth-related KROX20 gene in HFDPCs. Consuming banana flower extract for twelve weeks increased the hair root diameter and reduced hair loss and scalp redness compared to the placebo group. Thus, banana flower extract(HappyAngel^(■))can stimulate hair growth and inhibit the activation of hair loss genes.

关键词： Banana flower Dihydrotestosterone hair loss ROS Follicle dermal papilla cells

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Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling

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BIOCELL 2023年第8期47卷 1793-1802页

作者： FU-MING TSAI PING-HSUN LU LU-KAI WANG CHAN-YEN KUO MAO-LIANG CHEN CHUN-HUA WANG Department of Research Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan Department of Chinese Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Post-Baccalaureate Chinese Medicine Tzu Chi UniversityHualien970Taiwan Department of Life Sciences National Science and Technology CouncilTaipei106Taiwan Department of Dermatology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Medicine Tzu Chi UniversityHualien970Taiwan

Background:Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human *** often reduce the use of cisplatin due to its side effects,which in turn affects its *** study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for ***:Primary human follicle dermal papilla cells(HFDPCs)were used as target cells for cisplatininduced damage to hair *** blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs *** survival and cell cycle were analyzed by mitochondrial staining reagent WST-1 and propidium ***:Cisplatin could reduce the viability of HFDPCs without causing cell *** increased the level of phospho-Rad17 in HFDPCs and activated the Chk1/Cdc25C signaling to reduce the expression of Cdc2 protein,thereby arresting the cells in the G2/M *** combination of safflower extract and the flavonoids could effectively inhibit the signal transduction of Rad17/Chk1/Cdc25 in cisplatin-treated cells and reduce the cell population in the G2/M ***,we also confirmed that safflower extract could effectively inhibit the damage to HFDPCs caused by cisplatin,mainly at the level of reducing the DNA damage caused by ***:Safflower extract can be used as an adjuvant Chinese medicine for chemotherapy to reduce the damage caused by chemotherapy to normal hair follicle cells.

关键词： Safflower extract Cisplatin Human hair follicle dermal papilla cells Rad17 hair loss Cell cycle

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Polyphenol-Rich Olive Mill Wastewater Extract and Its Potential Use in hair Care Products

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第4期11卷 356-370页

作者： Lisa-Marie Sittek Thomas M. Schmidts Peggy Schlupp RSC Pharma GmbH & Co. KG Giessen Germany

In this work, the influence of phenol-enriched olive mill wastewater (OMWW) extract on hair growth was investigated in vitro on human follicle dermal papilla cells. OMWW has already shown great potential for use in skincare products, and its high polyphenol content is predestined to have a positive effect on hair growth. The studies included caffeine, a positive modulator of hair growth, and dihydrotestosterone, which causes hair loss in vivo, as controls. The impact of the investigated compounds on hair growth was evaluated by studies on cell viability and proliferation, the release of growth factors (insulin-like growth factor-1 and vascular endothelial growth factor), and the reduction of reactive oxygen species formation. OMWW showed a positive influence on the proliferation of the human follicle dermal papilla cells. Moreover, the extract leads to a significantly increased secretion of insulin-like growth factor-1, and a considerable reduction in reactive oxygen species formation was observed. Overall, our results show that the investigated phenol-enriched OMWW extract is a promising ingredient for hair care to improve hair growth, prevent hair loss due to oxidative stress and maintain a healthy scalp.

关键词： hair Growth hair loss Human Follicle Dermal Papilla Cells Caffeine Dihydrotestosterone IGF-1 VEGF Reactive Oxygen Species

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Safety and Efficacy of Deeply Rooted<sup>®</sup>Nutraceutical for hair Growth in Women

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Journal of Cosmetics, Dermatological Sciences and Applications 2020年第3期10卷 140-148页

作者： Pirko Maguina Debra Johnson and Rachael Frazier Sacramento USA

hair loss can significantly affect quality of life. Patients seeking treatment for hair loss find that many surgical or medication options involve significant risks or side effects. DEEPLY ROOTED® is a nutritional supplement that combines botanical and natural ingredients with the goal of effectively reducing hair loss and stimulating hair growth—without the side effects of many standard treatments. DEEPLY ROOTED’s active ingredients have both anti-inflammatory and adaptogenic properties, and inhibit dihydrotestosterone without the use of hormones, drugs, or industry by-products. This 3-month prospective study evaluates the effectiveness of DEEPLY ROOTED® for the prevention of hair loss. Healthy female subjects complaining of hair loss were enrolled, and supplied with three months of DEEPLY ROOTED®, without other compensation. The primary endpoint was a significant increase in hair growth. This was measured using anonymously collected patient data to evaluate hair growth and quality, as well as blinded Investigator hair assessment data. Patients who ingested DEEPLY ROOTED® over a three-month

关键词： hair loss Alopecia Supplement hair Growth Wellness Vitamins

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药物与手术相结合治疗AGA经验

药物与手术相结合治疗AGA经验

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2012全国中西医结合医学美容学术交流大会

作者：刘清中国美容医学杂志社

Objective:To explore and analyze the use of AGA treatment consensus on the hair transplant to regulate the timing of the research method,observation of patients with androgenetic alopecia contour improvement and evolution. Methods:Hamilton-Norwood classification typeⅢor more,older than 27 years old, the amount of hair loss before the main(M pattern hair loss) were 500 male patients were divided into 3 groups according to different age grups(27-35;35 - 45;45 above),according to the preoperative treatment will be from March to June,respectively,after drug treatment hair transplant hair transplant and direct groups,surgical unit and single hair follicles are used a combination of both techniques hair hairline profile and then plastic,analysis of treatment of one to two years follow-up changes and the appearance of self-evaluation to *** a follow-up after 12 months,through the comparative analysis of different age groups,the combination of drugs and surgery was better than the efficacy of surgical treatment,reflected in the hair sprouting again at speed,very low incidence of folliculitis,hair curl down. Results:Patients younger than 45 years,due to hair loss in advanced stages of transition to the stable to take into account the complementary role of drug to maintain a good appearance,it generally takes 3-6 months or 1 year of drug treatment,re-transplantation can be achieved satisfactory results;the age group above 45 years:from the hairline forward to appropriate medical treatment can be further controlled through the oily secretion of the hair into a stable,long-term medication after transplantation may not need adjuvant therapy, generally can achieve satisfactory ***:Drug adjuvant therapy for early hair loss in patients with a more important role in medium-term,early treatment can prevent reduction in the absolute number of hairs,to maintain a certain appearance,but in patients with advanced hair loss,hair transplantation is still a nec

关键词： hair loss AGA clinic consensus autologous hair transplantation combination of drugs and surgical treatment

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