Hair growth-promotion effects and antioxidant activity of the banana flower extract HappyAngel^(■):double-blind, placebo-controlled trial

作     者：Chia-Hua Liang Yung-Hsiang Lin Yung-Kai Lin Chi-Fu Chiang Chia-Hua Liang;Yung-Hsiang Lin;Yung-Kai Lin;Chi-Fu Chiang

作者机构：Department of Cosmetic Science and Institute of Cosmetic ScienceChia Nan University of Pharmacy and ScienceTainan 71710China Research&Design CenterTCI CO.Ltd.Taipei 114722China Institute of Food Safety and Risk ManagementDepartment of Food ScienceTaiwan Ocean UniversityKeelung 202301China Graduate Institute of Biomedical EngineeringChung Hsing UniversityTaichung 202301China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第5期

页      面：1917-1923页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

主　　题：Banana flower Dihydrotestosterone Hair loss ROS Follicle dermal papilla cells 

摘      要：Banana flowers contain various bioactive components, including several antioxidants with anti-inflammatory effects. However, it is unclear whether they can reduce and prevent hair loss. This study examines the effect of banana flower extracts on preventing hair loss and strengthening hair roots. The banana flower extract(HappyAngel^(■))was used to treat human hair follicle dermal papilla cells(HFDPCs)and the expression of reactive oxygen species(ROS), dihydrotestosterone(DHT), and hair-related genes(SRD5A1, SRD5A2, AR, and KROX20)were monitored. Fifty subjects were divided into a placebo group and a banana flower group. The experimental group consumed banana flower extract daily for twelve weeks and then underwent hair testing, hair-related genes analysis, collection of hair loss, and questionnaires. The results showed that the banana flower extract significantly increased hair cell growth and decreased the expression of ROS, DHT, and hair follicle growth inhibition-related SRD5A1, SRD5A2, and AR genes, and significantly increased the expression of hair growth-related KROX20 gene in HFDPCs. Consuming banana flower extract for twelve weeks increased the hair root diameter and reduced hair loss and scalp redness compared to the placebo group. Thus, banana flower extract(HappyAngel^(■))can stimulate hair growth and inhibit the activation of hair loss genes.