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Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy

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Cancer Biology & Medicine 2019年第4期16卷 756-770页

作者： Bin Liu Wen Cao Jin Cheng Sisi Fan Shaojun Pan Lirui Wang Jiaqi Niu Yunxiang Pan Yanlei Liu Xiyang Sun Lijun Ma Jie Song Jian Ni Daxiang Cui Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine Collaborative Innovational Center for System BiologyShanghai Jiao Tong UniversityShanghai 200240China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200030China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Oncology Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China

Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumor targeted ***:GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and *** cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry(FCM)and *** of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and *** fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic(CLSM)and FCM at different time *** ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by *** distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA *** combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing ***:The coated CaC03 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake *** as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic *** as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and ***:The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing *** fully utilizing the features of GNSs and NK cells,this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future.

关键词： gold nanostars natural killer cells photothermal therapy photodynamic therapy immunotherapy

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In situ synthesis of gold nanostars within liposomes for controlled drug release and photoacoustic imaging

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Science China Materials 2016年第11期59卷 892-900页

作者： Malathi Mathiyazhakan Paul Kumar Upputuri Kathyayini Sivasubramanian Ashish Dhayani Praveen Kumar Vemula 邹培超浦侃裔杨诚 Manojit Pramanik 徐臣杰 School of Chemical&Biomedical Engineering Nanyang Technological University62 Nanyang DriveSingapore Institute for Stem Cell Biology and Regenerative Medicine(inStem) GKVK-CampusBellary RoadBangaloreIndia Ramalingaswami Re-Entry Fellow Department of BiotechnologyNew Delhi 110003India Division of Energy&Environment Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China NTU-Northwestern Institute for Nanomedicine Nanyang Technological University50 Nanyang AvenueSingapore

This report describes the design and synthesis of gold nanostars(AuNSs) containing liposomes by the in situ reduction of gold precursor,HAuCU(pre-encapsulated within the liposomes) through HEPES diffusion and *** with the conventional process that encapsulates the pre-synthesized gold nanoparticles into liposomes during the thin-film hydration step,this facile and convenient method allows the formation and simultaneous encapsulation of AuNSs within *** absorption spectra of AuNSs can be tuned between visible and near infra-red(NIR) regions by controlling the size and morphology of AuNSs through varying the concentrations of HAuCU and *** a proof of concept,we demonstrate the synthesis of AuNSs with a maximum absorbance at 803 nm within the temperature-sensitive *** liposomes can produce stronger photoacoustic signals(1.5 fold) in the NIR region than ***,when there are drugs(i.e.,doxorubicin) within these liposomes,the irradiation with the NIR pulse laser will disrupt the liposomes and trigger the 100%release of these pre-encapsulated drugs within 10 *** comparison,there is neglectable contrast enhancement or minor release(10%) of drugs for the pure liposomes under the same ***,cell experiment shows the potential therapeutic application of this system.

关键词： gold nanostars light sensitive liposomes controlled drug release photoacoustic imaging

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Selective deposition of a MOF at the spikes of Au nanostars for SERS detection

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Nano Research 2024年第10期17卷 9166-9173页

作者： Yi Liu Ka Kit Chui Xinyue Xia Han Zhang Xiaolu Zhuo Jianfang Wang School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China Department of Physics The Chinese University of Hong KongShatinHong Kong 999077China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310000China

In the pursuit of advancing molecular sensing through surface-enhanced Raman spectroscopy(SERS),the combination of plasmonic nanoparticles and metal-organic frameworks(MOFs)has emerged as a highly effective approach to enhance the sensitivity and selectivity of SERS ***,most prior investigations have predominantly focused on MOF-coated plasmonic nanoparticles in core@shell or layer-by-layer configurations,leaving a notable knowledge gap in exploring alternative *** we present a facile method to construct a particle-on-mirror architecture by selectively coating a MOF,zeolitic imidazolate framework-8(ZIF-8),onto the tips of Au nanostars and subsequently depositing the resultant nanoparticles onto a Au *** design integrates the electric field enhancement at the sharp tips and nanogaps,along with the molecular enrichment function within the porous MOF immobilized at the tips and nanogaps,leading to a substantial boost in the SERS signal *** a unique SERS platform enables consistent and outstanding SERS performance for analytes of different *** work opens up a promising strategy for constructing multifunctional nanostructures for sensitive SERS detection in real-life scenarios.

关键词： electric field enhancement gold nanostars metal-organic frameworks molecular enrichment plasmon coupling surfaceenhanced Raman spectroscopy(SERS)substrates

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Hot spots enriched plasmonic nanostructure-induced random lasing of quantum dots thin film

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Chinese Physics B 2018年第4期27卷 497-502页

作者： Feng Shan Xiao-Yang Zhang Jing-Yuan Wu Tong Zhang Joint International Research Laboratory of Information Display and Visualization School of Electronic Science and Engineering Southeast University Nanjing 210096 China Key Laboratory of Micro-Inertial Instrument and Advanced Navigation Technology Ministry of Education and School of Instrument Science and Engineering Southeast University Nanjing 210096 China Suzhou Key Laboratory of Metal Nano-Optoelectronic Technology Suzhou Research Institute of Southeast University Suzhou 215123 China

Here,a plasmon-enhanced random laser was achieved by incorporating gold nanostars（NS） into disordered polymer and Cd Se/Zn S quantum dots（QDs） gain medium films,in which the surface plasmon resonance of gold NS can greatly enhance the scattering cross section and bring a large gain *** random distribution of gold NS in the gain medium film formed a laser-mode *** a single-pulse pumping,the scattering center of gold NS-based random laser exhibits enhanced performance of a lasing threshold of 0.8 m J/cm^2 and a full width as narrow as 6 nm at half *** utilizing the local enhancement characteristic of the electric field at the sharp apexes of the gold NS,the emission intensity of the random laser was *** addition,the gold NS showed higher thermal stability than the silver nanoparticles,withstanding high temperature heating up to 200？*** results of metal nanostructures with enriched hot spots and excellent temperature stability have tremendous potential applications in the fields of biological identification,medical diagnostics,lighting,and display devices.

关键词： plasmon gain medium gold nanostars random laser

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A review of metal nanoparticle-based surface-enhanced Raman scattering substrates for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)detection Special Collection:Distinguished Australian Researchers

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Aggregate 2023年第5期4卷 1-11页

作者： Norhayati Abu Bakar Nur Nazhifah Yusoff Farah Shahadah Nor Azmi Joseph George Shapter Australian Institute for Bioengineering and Nanotechnology University of QueenslandSt LuciaAustralia Institute of Microengineering and Nanoelectronics Universiti Kebangsaan MalaysiaBangiMalaysia

Monitoring an infectious disease early using highly sensitive and non-invasive techniques is critical for human ***,the development of surfaceenhanced Raman scattering(SERS)for biological detection ideally fits these medical requirements and is rapidly growing as a powerful diagnostic *** can enhance the Raman signal of the target molecule by more than 106 after the adsorption of the molecule on the plasmonic nanostructured *** review provides an overview of the use of gold and silver nanoparticles in SERS substrate designs,followed by the development of these SERS substrates in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)detection.

关键词： gold nanostars SARS-CoV-2 SERS silver nanostars

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Anisotropic gold nanoparticles: Preparation and applications in catalysis

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Chinese Journal of Catalysis 2016年第10期37卷 1619-1650页

作者： Peter Priecel Hammed Adekunle Salami Romen Herrera Padilla Ziyi Zhong Jose Antonio Lopez-Sanchez 利物浦大学化学系可再生能源斯蒂芬森研究所英国利物浦新加坡科技研究局(A*STAR) 化学与工程科学研究所新加坡裕廊岛627833

Despite the high amount of scientific work dedicated to the gold nanoparticles in catalysis, most of the research has been performed utilising supported nanoparticles obtained by traditional impreg‐nation of gold salts onto a support, co‐precipitation or deposition‐precipitation methods which do not benefit from the recent advances in nanotechnologies. Only more recently, gold catalyst scien‐tists have been exploiting the potential of preforming the metal nanoparticles in a colloidal suspen‐sion before immobilisation with great results in terms of catalytic activity and the morphology con‐trol of mono‐and bimetallic catalysts. On the other hand, the last decade has seen the emergence of more advanced control in gold metal nanoparticle synthesis, resulting in a variety of anisotropic gold nanoparticles with easily accessible new morphologies that offer control over the coordination of surface atoms and the optical properties of the nanoparticles （tunable plasmon band） with im‐mense relevance for catalysis. Such morphologies include nanorods, nanostars, nanoflowers, den‐dritic nanostructures or polyhedral nanoparticles to mention a few. In addition to highlighting newly developed methods and properties of anisotropic gold nanoparticles, in this review we ex‐amine the emerging literature that clearly indicates the often superior catalytic performance and amazing potential of these nanoparticles to transform the field of heterogeneous catalysis by gold by offering potentially higher catalytic performance, control over exposed active sites, robustness and tunability for thermal‐, electro‐and photocatalysis.

关键词： Anisotropic metal nanoparticles gold nanoparticles gold catalysis Photocatalysis Electrocatalysis Catalytic oxidation Colloidal gold nanoparticles gold nanorod gold nanostars Sol immobilisation

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