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Effect of a 26-month floorball training on male elderly's cardiovascular fitness, glucose control, body composition, and functional capacity

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Journal of Sport and Health Science 2018年第2期7卷 149-158页

作者： Mogens Theisen Pedersen Jacob Vorup Jens Bangsbo Copenhagen Centre of Team Sport and Health Department of NutritionExercise and SportsSection of Integrated PhysiologyUniversity of Copenhagen Health Science Research Center University College Lillebaelt

Background: Floorball training offers a motivating and socially stimulating team activity for older adults, and 12 weeks of floorball training twice a week among men aged 65—76 years have been shown to have positive effects on a number of physiological parameters important for health. However, the effect of long-term participation in floorball training among male elderly has not been investigated. The aim of the present study was to examine the effect of 26-month self-organized regular participation in floorball training on cardiovascular fitness, body composition, blood lipids, glucose control, and physical function among recreationally active men aged 66—78 ***: After completing a 12-week randomized and controlled intervention with floorball and petanque training in the autumn 2014 or spring2015, 15 subjects chose to participate in floorball training(floorball group, FG), whereas 16 subjects resumed their usual lifestyle(control group,CG). FG took part in self-organized floorball training 1.7 sessions of 40 min/week, and CG continued their normal recreationally active lifestyle during a 26-month follow-up period. At baseline and after the follow-up period subjects were tested for cardiovascular fitness, glucose control(resting blood samples), body composition dual-energy X-ray absorptiometry(DXA-scanning), and functional ***: In FG, the decline in maximal oxygen uptake(VO_(2max)) during the follow-up period was lower(242 ± 379 mL/min, p = 0.01), blood glycosylated hemoglobin(HbA1c) increased less(—1.6 ± 2.9 mmol/L, p = 0.02), and leg bone mineral density increased more(0.03 ± 0.05 g/cm^2,p = 0.02) than those in CG. The effects on body mass, total lean body mass, fat mass, blood lipids, and physical function were similar in FG and ***: Approximately twice weekly floorball sessions with 40 min/session over 26-month appear to reduce age-related decline in cardiovascular fitness and glucose control and improve leg bone mineral density,

关键词： Bone mineral density Elderly Floorball glucose control VO2max

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Balancing act:The dilemma of rapid hyperglycemia correction in diabetes management

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World Journal of Diabetes 2024年第2期15卷 129-132页

作者： Ke-Xin Zhang Cheng-Xia Kan Xiao-Dong Sun Department of Endocrinology and Metabolism Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

The global diabetes surge poses a critical public health challenge,emphasizing the need for effective glycemic ***,rapid correction of chronic hyperglycemia can unexpectedly trigger microvascular complications,necessitating a reevaluation of the speed and intensity of glycemic *** suggest swift blood sugar reductions may cause inflammation,oxidative stress,and neurovascular changes,resulting in *** providers should cautiously approach aggressive glycemic control,especially in long-standing,poorly controlled *** and managing these complications requires a personalized,comprehensive approach with education,monitoring,and interdisciplinary *** management must balance short and longterm goals,prioritizing overall *** editorial underscores the need for a personalized,nuanced approach,focusing on equilibrium between glycemic control and avoiding overcorrection.

关键词： Diabetes Hyperglycemia correction Management Microvascular complications glucose control

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Transplantation for the treatment of type 1 diabetes

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World Journal of Gastroenterology 2007年第47期13卷 6347-6355页

作者： R Mark Meloche Department of Surgery University of British ColumbiaVancouverBritish ColumbiaCanada

Transplantation of pancreatic tissue, as either the intact whole pancreas or isolated pancreatic islets has become a clinical option to be considered in the treatment of patients with type 1 insulin-dependant diabetes mellitus. A successful whole pancreas or islet transplant offers the advantages of attaining normal or near normal blood glucose control and normal hemoglobin Alc levels without the risks of severe hypoglycemia associate with intensive insulin therapy. Both forms of transplants are also effective at eliminating the occurrence of significant hypoglycemic events （even with only partial islet function evident）. Whereas whole pancreas transplantation has also been shown to be very effective at maintaining a euglycemic state over a sustained period of time, thus providing an opportunity for a recipient to benefit from improvement of their blood glucose control, it is associated with a significant risk of surgical and post-operative complications. Islet transplantation is attractive as a less invasive alternative to whole pancreas transplant and offers the future promise of immunosuppression-free transplantation through pretransplant culture. Islet transplantation however, may not always achieve the sustained level of tight glucose control necessary for reducing the risk of secondary diabetic complications and exposes the patient to the adverse effects of immunosuppression. Although recent advances have led to an increased rate of obtaining insulin-independence following islet transplantation, further developments are needed to improve the longterm viability and function of the graft to maintain improved glucose control over time.

关键词： Type 1 diabetes Insulin-dependant diabetes mellitus Pancreas transplantation Pancreatic islet transplantation Immunosuppression glucose control

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No significant association between dipeptidyl peptidase-4 inhibitors and adverse outcomes of COVID-19

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World Journal of Clinical Cases 2020年第22期8卷 5576-5588页

作者： Jiang-Hua Zhou Bin Wu Wen-Xin Wang Fang Lei Xu Cheng Juan-Juan Qin Jing-Jing Cai Xiao-Jing Zhang Feng Zhou Ye-Mao Liu Hao-Miao Li Li-Hua Zhu Zhi-Gang She Xin Zhang Juan Yang Hong-Liang Li Department of Cardiology Renmin Hospital of Wuhan UniversityBasic Medical SchoolWuhan UniversityWuhan 430071Hubei ProvinceChina Basic Medical School Institute of Model AnimalWuhan UniversityWuhan 430071Hubei ProvinceChina Department of Cardiology the 3rd Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Medical Science Research Center Zhongnan Hospital of Wuhan UniversityInstitute of Model AnimalWuhan UniversityWuhan 430072Hubei ProvinceChina Department of Cardiology Renmin Hospital of Wuhan UniversityInstitute of Model Animal of Wuhan UniversityWuhan 430071Hubei ProvinceChina Institute of Model Animal Wuhan UniversityDepartment of GastroenterologyWuhan Third HospitalTongren Hospital of Wuhan UniversityWuhan 430072Hubei ProvinceChina

BACKGROUND Dipeptidyl peptidase-4(DPP4)is commonly targeted to achieve glycemic control and has potent anti-inflammatory and immunoregulatory *** structural analyses indicated a potential tight interaction between DPP4 and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),raising a promising hypothesis that DPP4 inhibitor(DPP4i)drugs might be an optimal strategy for treating coronavirus disease 2019(COVID-19)among patients with ***,there has been no direct clinical evidence illuminating the associations between DPP4i use and COVID-19 *** To illuminate the associations between DPP4i usage and the adverse outcomes of *** We conducted a multicenter,retrospective analysis including 2563 patients with type 2 diabetes who were hospitalized due to COVID-19 at 16 hospitals in Hubei Province,*** excluding ineligible individuals,142 patients who received DPP4i drugs and 1115 patients who received non-DPP4i oral anti-diabetic drugs were included in the subsequent *** performed a strict propensity score matching(PSM)analysis where age,sex,comorbidities,number of oral hypoglycemic agents,heart rate,blood pressure,pulse oxygen saturation(SpO2)<95%,CT diagnosed bilateral lung lesions,laboratory indicators,and proportion of insulin usage were ***,111 participants treated with DPP4i drugs were successfully matched to 333 non-DPP4i ***,a linear logistic model and mixed-effect Cox model were applied to analyze the associations between inhospital DPP4i use and adverse outcomes of *** After rigorous matching and further adjustments for imbalanced variables in the linear logistic model and Cox adjusted model,we found that there was no significant association between in-hospital DPP4i use(DPP4i group)and 28-d allcause mortality(adjusted hazard ratio=0.44,95%CI:0.09-2.11,P=0.31).Likewise,the incidences and risks of secondary outcomes,including septic shock,acute respiratory distress synd

关键词： COVID-19 SARS-CoV-2 DPP4 inhibitors Diabetes glucose control Adverse effects

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Effects of glycaemic management on diabetic kidney disease

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World Journal of Diabetes 2017年第5期8卷 172-186页

作者： Richard J MacIsaac George Jerums Elif I Ekinci Department of Endocrinology and Diabetes St Vincent’s Hospital Department of Medicine University of Melbourne Endocrine Centre Austin Health

Hyperglycaemia contributes to the onset and progression of diabetic kidney disease(DKD). Observational studies have not consistently demonstrated a glucose threshold, in terms of HbA1c levels, for the onset of DKD. Tight glucose control has clearly been shown to reduce the incidence of micro-or macroalbuminuria. However, evidence is now also emerging to suggest that intensive glucose control can slow glomerular filtration rate loss and possibly progression to end stage kidney disease. Achieving tight glucose control needs to be balanced against the increasing appreciation that glucose targets for the prevention of diabetes related complications need be individualised for each patient. Recently, empagliflozin which is an oral glucose lowering agent of the sodium glucose cotransporter-2 inhibitor class has been shown to have renal protective effects. However, the magnitude of empagliflozin's reno-protective properties are over and above that expected from its glucose lowering effects and most likely largely result from mechanisms involving alterations in intra-renal haemodynamics. Liraglutide and semaglutide, both injectable glucose lowering agents which are analogues of human glucagon like peptide-1 have also been shown to reduce progression to macroalbuminuria through mechanisms that remain to be fully elucidated. Here we review the evidence from observational and interventional studies that link good glucose control with improved renal outcomes. We also briefly review the potential reno-protective effects ofnewer glucose lowering agents.

关键词： Diabetic nephropathy Albuminuria glucose control Glomerular filtration rate Diabetes Chronic kidney disease Empagliflozin Liraglutide Semaglutide

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Differences in metabolic improvement after metabolic surgery are linked to the gut microbiota in non-obese diabetic rats

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1304-1316页

作者： Xin Luo Cai Tan Fang Tao Chi-Ying Xu Zhi-Hua Zheng Qiang Pang Xiang-An He Jia-Qing Cao Jin-Yuan Duan Department of General Surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Women’s Health Jiangxi Maternal and Child Health HospitalNanchang 330006Jiangxi ProvinceChina Department of General Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina

BACKGROUND Different metabolic/bariatric surgery approaches vary in their effect on weight loss and glucose levels,although the underlying mechanism is *** have demonstrated that the gut microbiota might be an important mechanism of improved metabolism after metabolic/bariatric *** To investigate the relationship between the improvement in metabolic disturbances and the changes in gut microbiota after gastric or intestinal *** We performed sleeve gastrectomy(SG),distal small intestine bypass(DSIB)or sham surgery in nonobese rats with diabetes induced by 60 mg/kg streptozotocin(STZ-DM).RESULTS The group comparisons revealed that both SG and DSIB induced a reduction in body weight and significant improvements in glucose and lipid metabolism in the STZ-DM ***,DSIB exhibited a stronger glucose-lowering and lipidreducing effect on STZ-DM rats than SG.16S ribosomal RNA gene sequencing revealed the gut abundance of some Lactobacillus *** in both the SG and DSIB groups after ***,the DSIB group exhibited a more pronounced increase in the gut abundance of Lactobacillus *** to the SG group,with more Lactobacillus *** increased in the *** The gut abundance of Lactobacillus was significantly correlated with the improvement in glycolipid metabolism and the change in serum fibroblast growth factor 21 levels.

关键词： Diabetes glucose control Lipid metabolism Microbiota Obesity Gastrectomy Distal small intestine bypass

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Metabolic and functional effects of exercise training in diabetic kidney transplant recipients

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World Journal of Transplantation 2022年第7期12卷 184-194页

作者： Vassiliki Michou Maria Nikodimopoulou Asterios Deligiannis Evangelia Kouidi Sports Medicine Laboratory School of Physical Education&Sport ScienceAristotle UniversityThessaloniki 57001Greece Transplant Surgery Clinic of Aristotle University of Thessaloniki Hippokration General HospitalThessaloniki 54642Greece

BACKGROUND Physical activity levels are significantly lower in kidney transplant(KT)recipients compared to the general *** effects of exercise training in KT recipients with diabetes mellitus remain unclear,and so little is known about the role of increased exercise on cardiovascular risk and metabolic profile of KT *** To investigate the effects of a 6-mo home-based exercise training program on functional capacity,glucose levels and lipid profile of diabetic KT *** In total,21 type II diabetic KT recipients were randomly assigned into two groups:Exercise(n=11,aged 52.9±10.1 years)and control(n=10,aged 53.01±9.5 years).All participants at baseline and the end of the study underwent biochemical tests for fasting plasma glucose levels,glycated hemoglobin and lipid profile and cardiopulmonary exercise testing for maximum oxygen uptake[(VO2)peak]*** exercise group followed a 6-mo supervised home-based aerobic and progressive resistance exercise program of moderate intensity 3 times per week,while the control group continued to receive usual *** At the end of the 6-mo study,the exercise group had significantly lower values in fasting plasma glucose by 13.4%(from 120.6±28.9 mg/dL to 104.8±21.9 mg/dL,P=0.01),glycated hemoglobin by 1.5%(from 6.7%±0.4 to 6.6%±0.4,P=0.01)and triglycerides by 8.5%(from 164.7±14.8 mg/dL to 150.8±11.6 mg/dL,Pcontrol *** were statistically significant differences between the two groups at the end of the study for fasting plasma glucose(decreased by 9.6%,P<0.05),triglycerides(decreased by 4.5%,P=0.04)and(VO_(2))_(peak)(increased by 4.4%,P=0.01).Finally,after training,there was a moderate,positive linear relationship between(VO_(2))_(peak)and glycated hemoglobin in the exercise group(r=0.408,P=0.03).CONCLUSION The res

关键词： Renal transplant recipients Diabetes mellitus exercise Lipid profile glucose control Functional capacity

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Recent advances in glucose-responsive insulin delivery systems:novel hydrogels and future applications

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Regenerative Biomaterials 2022年第1期9卷 1037-1045页

作者： Avha R.Mohanty Akhila Ravikumar Nicholas A.Peppas McKetta Department of Chemical Engineering The University of Texas at Austin200 E Dean Keeton StAustinTX 78712USA Institute for Biomaterials Drug Deliveryand Regenerative MedicineThe University of Texas at Austin107WDean Keeton StAustinTX 78712USA Department of Biomedical Engineering The University of Texas at Austin107WDean Keeton StAustinTX 78712USA Division of Molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at Austin2409 University AveAustinTX 78712USA Department of Surgery and Perioperative Care Dell Medical SchoolThe University of Texas at Austin1501 Red River StAustinTX 78712USA Department of Pediatrics Dell Medical SchoolThe University of Texas at Austin1501 Red River StAustinTX 78712USA

Over the past several decades,there have been major advancements in the field of glucose sensing and insulin delivery for the treatment of type I diabetes *** introduction of closed-loop insulin delivery systems that deliver insulin in response to specific levels of glucose in the blood has shifted significantly the research in this *** systems consist of encapsulated glucose-sensitive components such as glucose oxidase or phenylboronic acid in hydrogels,microgels or *** our previous evaluation of these systems in a contribution in 2004,new systems have been *** improvements in key issues,such as consistent insulin delivery over an extended period of time have been *** this contribution,we discuss recent advancements over the last 5 years and present persisting issues in these technologies that must be overcome in order for these systems to be applicable in patients.

关键词： insulin delivery glucose control hydrogels glucose oxidase diabetes

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Patterns and Changes in the Treatment of Patients with Type II Diabetes Mellitus in Egypt: The DISCOVER Program

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International Journal of Clinical Medicine 2020年第12期11卷 731-742页

作者： Salah Shelbaya Mohamed Khattab Khalifa Abdallah Yehia Ghanem Hesham El Hefnawy Enas Shaltout Eman Roshdy Emad R. Issak Endocrinology Department Ain Shams University Cairo Egypt Internal Medicine Department Cairo University Giza Egypt Internal Medicine Department Alexandria University Alexandria Egypt Endocrinology Department National Institute of Diabetes & Endocrinology Cairo Egypt Internal Medicine Department Diabetes Unit Cairo University Giza Egypt Internal Medicine Department Ain Shams University Cairo Egypt

The DISCOVER study is a three-year, non-interventional prospective study conducted in 37 countries, including Egypt, to assess the treatment patterns and outcomes in patients with type 2 diabetes mellitus initiating a second-line antidiabetic therapy (add-on or switch). In this report of the Egyptian cohort of DISCOVER, baseline data were collected according to routine clinical practice at 38 study sites, using a standardized electronic case report form, in the period from December-2014 to November-2019. We enrolled 583 patients (mean age: 52.9 ± 9.8 years and median duration since diagnosis: median 36.5, IQR 18.1, 70.4 months). The mean HbA1c value at baseline was 8.6 ± 1.4%, indicating poor glycemic control. The most commonly prescribed first-line medications were metformin or sulfonylurea monotherapy. For second line-therapy, the majority of patients switched to dual therapy with metformin plus sulfonylureas or DPP-4 inhibitors. Fewer patients switched to triple therapy, treatment by four or more medications, or insulin treatment (15, 12, and 35 patients, respectively). The most commonly cited reasons for switching to second-line therapy were lack of efficacy, weight gain, hypoglycemic events, and side effects (549, 54, 25, and 21 patients, respectively). The set treatment target of enrolled patients at the initiation of second-line therapy was an HbA1c level of 6.9%. Follow-up data will assess the outcomes of such changes in the Egyptian population.

关键词： Diabetes Mellitus glucose control Metformin Patient-Reported Outcomes Egypt HbA1c Medication

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Medical Nutritional Therapy for Pre-gestational and Gestational Diabetes Mellitus

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Journal of Health Science 2018年第2期6卷 79-90页

作者： Lois Jovanovic Keck University Medical School Los Angeles California USA University of Southern California Santa Barbara 93109 California USA

Pregnancy causes a multitude of metabolic changes within a woman’s body in order to provide the proper nutrients to the developing fetus. In women with diabetes type 1, type 2, and GDM （gestational diabetes mellitus） these metabolic perturbations must be treated distinctly and aggressively to optimize fetal development and health. Pre-gestational diabetes （either type 1 or type 2） has the potential to subject the developing fetus to abnormal maternal glucose levels resulting in problems with organogenesis producing congenital abnormalities or spontaneous abortion. Furthermore, gestational diabetes mellitus presents after organogenesis in the second part of pregnancy, therefore the major risk for the fetus is macrosomia. Although the goal for dietary therapy for each of these disorders is the same which is euglycaemia, the means to achieve it are very different and somewhat controversial. In the case of gestational diabetes, the main stay of therapy is medical nutritional therapy whereas in insulin requiring diabetes, dietary therapy is compensated with pre-meal insulin injections. The metabolic changes in normal pregnancy will be presented followed by the general guidelines for pregnancy. Fetal complications associated with inadequate nutrition or metabolic perturbation will be briefly explored, followed by issues and treatment for gestational diabetes mellitus, with emphasis on specific dietary therapies for GDM.

关键词： glucose control peak post prandial glucose concentration macrosomnia pregnancy glucose mediated complications of pregnancy.

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