Recent advances in glucose-responsive insulin delivery systems:novel hydrogels and future applications

作     者：Avha R.Mohanty Akhila Ravikumar Nicholas A.Peppas 

作者机构：McKetta Department of Chemical EngineeringThe University of Texas at Austin200 E Dean Keeton StAustinTX 78712USA Institute for BiomaterialsDrug Deliveryand Regenerative MedicineThe University of Texas at Austin107WDean Keeton StAustinTX 78712USA Department of Biomedical EngineeringThe University of Texas at Austin107WDean Keeton StAustinTX 78712USA Division of Molecular Pharmaceutics and Drug DeliveryCollege of PharmacyThe University of Texas at Austin2409 University AveAustinTX 78712USA Department of Surgery and Perioperative CareDell Medical SchoolThe University of Texas at Austin1501 Red River StAustinTX 78712USA Department of PediatricsDell Medical SchoolThe University of Texas at Austin1501 Red River StAustinTX 78712USA 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2022年第9卷第1期

页      面：1037-1045页

核心收录：

学科分类：081702[工学-化学工艺] 1002[医学-临床医学] 08[工学] 0817[工学-化学工程与技术] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported in part by the Dean of the Cockrell School of Engineering at The University of Texas at Austin for the Institute for Biomaterials,Drug Delivery and Regenerative Medicine the UT-Portugal Collaborative Research Program 

主　　题：insulin delivery glucose control hydrogels glucose oxidase diabetes 

摘      要：Over the past several decades,there have been major advancements in the field of glucose sensing and insulin delivery for the treatment of type I diabetes *** introduction of closed-loop insulin delivery systems that deliver insulin in response to specific levels of glucose in the blood has shifted significantly the research in this *** systems consist of encapsulated glucose-sensitive components such as glucose oxidase or phenylboronic acid in hydrogels,microgels or *** our previous evaluation of these systems in a contribution in 2004,new systems have been *** improvements in key issues,such as consistent insulin delivery over an extended period of time have been *** this contribution,we discuss recent advancements over the last 5 years and present persisting issues in these technologies that must be overcome in order for these systems to be applicable in patients.