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The protective effect of W026B on global cerebral ischemia/reperfusion injury model in rats

Journal of Chinese Pharmaceutical Sciences 2022年第2期31卷 108-116页

作者： Ziyi Wang Xiaoyan Liu Yuanjun Zhu Ye Liu Pingping Zhang Yinye Wang Department of Molecular and Cellular Pharmacology School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Beijing Honghui New Medical Technology Co. Ltd.Beijing Daxing Biological Medicine Industry BaseBeijing 102600China

cerebral ischemia seriously affects the quality of life and health of human worldwide.W026B is a newly synthesized lignan derivative that has a protective effect on the focal cerebral ischemia/reperfusion model,while it is unclear whether W026B has a cerebral protective effect on the model of global cerebral ischemia/reperfusion(GCI/R).In this study,we investigated the protective effect of W026B on the four-vessel occlusion GCI/R *** results showed that W026B obviously increased the survival rate of rats during 7 d after GCI/R and significantly improved neurological deficits within 7 d after GCI/*** evidently enhanced the number of survival neurons in the hippocampus of GCI/R ***,W026B notably lowered the level of ROS,and increased the activity of SOD in the hippocampus of GCI/R ***,it also decreased the expression of NF-κB p65 and the level of IL-6 *** addition,W026B evidently lowered the activity of *** conclusion,this study firstly proves that W026B has the protective effect on GCI/R *** cerebral protective effect maybe related to the inhibition of oxidative stress,inflammatory response,and cell apoptosis during GCI/*** results provide new evidence with the protective effect of W026B on cerebral ischemia/reperfusion injury.

关键词： global cerebral ischemia/reperfusion W026B Neurobehavior Oxidative stress Inflammation Apoptosis

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Tea polyphenols increase X-ray repair cross-complementing protein 1 and apurinic/apyrimidinic endonuclease/redox factor-1 expression in the hippocampus of rats during cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2012年第30期7卷 2355-2361页

作者： Zhi Wang Rongliang Xue Xi Lei Jianrui Lv Gang Wu Wei Li Li Xue Xiaoming Lei Hongxia Zhao Hui Gao Xin Wei Department of Anesthesiology Second Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Department of Anesthesiology Stomatological Hospital Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China

Recent studies have shown that tea polyphenols can cross the blood-brain barrier, inhibit apoptosis and play a neuroprotective role against cerebral ischemia. Furthermore, tea polyphenols can decrease DNA damage caused by free radicals. We hypothesized that tea polyphenols repair DNA damage and inhibit neuronal apoptosis during global cerebral ischemia/reperfusion. To test this hypothesis, we employed a rat model of global cerebral ischemia/reperfusion. We demonstrated that intraperitoneal injection of tea polyphenols immediately after reperfusion significantly reduced apoptosis in the hippocampal CA1 region; this effect started 6 hours following reperfusion. Immunohistochemical staining showed that tea polyphenols could reverse the ischemia/reperfusion-induced reduction in the expression of DNA repair proteins, X-ray repair cross-complementing protein 1 and apudnic/apyrimidinic endonuclease/redox factor-1 starting at 2 hours. Both effects lasted at least 72 hours. These experimental findings suggest that tea polyphenols promote DNA damage repair and protect against apoptosis in the brain.

关键词： global cerebral ischemia/reperfusion X-ray repair cross-complementing protein 1 apurinic/apyrimidinic endonuclease/redox factor-I tea polyphenols

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