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ginsenoside-rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway

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Chinese Journal of Natural Medicines 2023年第7期21卷 540-550页

作者： HUANG Yu YANG Hui YANG Biying ZHENG Yu H OU Xiaomei CHEN Guiling ZHANG Wenqi ZENG Xiang DU Baoxin Labortory of Stem Cell Clinical Reaearch The Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou 510006China Labortory of Stem Cell Biology and Chinese Medicine The Second Afiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006China Labortory of Stem Cell Biology and Chinese Medicine Guangdong Provincial Academy of Chinese Medical SciencesGuangzhou 510006China Labortory of Stem Cell Clinical Research Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510006China Department of Neurology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510006China

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease affecting both upper and lower motor neurons in the brain and spinal *** important aspect of ALS pathogenesis is superoxide dismutase 1(SOD1)mutant-mediated mitochondrial toxicity,leading to apoptosis in *** study aimed to evaluate the neural protective synergistic effects of ginsenosides rg1(G-rg1)and conditioned medium(CM)on a mutational SOD1 cell model,and to explore the underlying *** found that the contents of nerve growth factor,glial cell line-derived neurotrophic factor,and brain-derived neurotrophic factor significantly increased in CM after human umbilical cord mesenchymal stem cells(hUCMSCs)were exposed to neuron differentiation reagents for seven *** or G-rg1 decreased the apoptotic rate of SOD1^(G93A)-NSC34 cell to a certain extent,but their combination brought about the least apoptosis,compared with CM or G-rg1 *** research showed that the anti-apoptotic protein Bcl-2 was upregulated in all the treatment *** associated with mitochondrial apoptotic pathways,such as Bax,caspase 9(Cas-9),and cytochrome c(Cyt c),were ***,CM or G-rg1 also inhibited the activation of the nuclear factor-kappa B(NF-κB)signaling pathway by reducing the phosphorylation of p65 and Iκ***/G-rg1 or their combination also reduced the apoptotic rate induced by betulinic acid(BetA),an agonist of the NF-κB signaling *** summary,the combination of CM and G-rg1 effectively reduced the apoptosis of SOD1^(G93A)-NSC34 cells through suppresing the NF-κB/Bcl-2 sgaling pathway(Fig.1 is a graphcal representation of the abstract).

关键词： Apoptosis Amyotrophic lateral sclerosis Conditioned medium ginsenoside-rg1 Umbilical cord mesenchymal stem cells

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Anti-amnestic and anti-aging effects of ginsenoside rg1 and Rb1 and its mechanism of action

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Acta Pharmacologica Sinica 2005年第2期26卷 143-149页

作者： Yong CHENG Li-hong SHEN Jun-tian ZHANG Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100050,China Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China

In the present paper,we overview the discovery of new biological activitiesinduced by ginsenoside rg1 and Rb1 and discuss possible mechanisms of *** compounds could increase neural plasticity in efficacy and structure;espe-cially rg1,as one small molecular drug,can increase proliferation and differentia-tion of neural progenitor cells in dentate gyrus of hippocampus of normal adultmice and global ischemia model in *** finding has great value for treat-ment of Alzheimer’s disease and other neurodegenerative disorders which is char-acterized by neurons *** of expression of brain derived neurotrophicfactor,Bcl-2 and antioxidant enzyme,enhanced new synapse formation,inhibitionof apoptosis and calcium overload are also important neuron protective *** and Rbl have common effects,but there are some differences in pharmacol-ogy and *** differences may attribute to their different ***1 is panaxtriol with two sugars,while Rb1 is panaxtriol with foursugars.

关键词： ginseng ginsenoside-rg1 ginsenoside-Rb1 learning memory neural progenitor cells apoptosis immunity synaptic plasticity muscarinic cholinergic receptor long-term potentiation

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Neuroprotection of ginsenoside rgl on Aβ 25-35-induced toxicity in primary cultured rat cortical neurons via NF-κB/NO pathway

Neuroprotection of ginsenoside Rgl on Aβ 25-35-induced toxi...

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2015年浙江省医学会临床药学分会、浙江省中西医结合学会中药分会学术会议

作者： Jiaying Wu Hongyu Yang Qingwei Zhao Xingguo Zhang Yijia Lou Department of Pharmacy The First Affiliated HospitalCollege of MedicineZhejiang University Division of Cardio-Cerebral Vascular and Hepatic Pharmacology College of Pharmaceutical SciencesZhejiang University

ginsenoside rg1(rg1) is a multipotent triterpene saponins extracted from the traditional Chinese medicine ginseng,and has been proven to be a nootropic agent against diverse neurological *** current study was designed to investigate the neuroprotective effect and the underlying mechanisms of rg1 on apoptosis induced by β-amyloid peptide 25-35(A β 25-35) in the primary cultured cortical *** primary neurons were preincubated with 20 μM rg1 for 24 h and exposed to 10 μM A β 25-35 for 72 *** this study,we found that rg1 prevented the NF- κB nuclear translocation and the I κ B- α phosphorylation in primary cultured cortical neurons after A β 25-35 exposure by scavenging excess *** addition,rg1 successfully suppressed A β 25-35-induced iNOS expression and NO production in a NF-κB-dependent *** of rg1 elevated the proportion of Bcl-2/Bax,lessened the release of cytochrome c from mitochondria into cytoplasm and then interdicted mitochondrial apoptotic cascades after A β 25-35 insult by lowering NO *** together,our data demonstrate that rg1 may rescue primary cultured cortical neurons from Aβ 25-35-caused cell apoptosis via down-regulating NF-κB/NO signaling pathway.

关键词： ginsenoside-rg1 Aβ neuroprotection NF-κB iNOS apoptosis

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