Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action
Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action作者机构：Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2005年第26卷第2期
页 面：143-149页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：ginseng ginsenoside-Rg1 ginsenoside-Rb1 learning memory neural progenitor cells apoptosis immunity synaptic plasticity muscarinic cholinergic receptor long-term potentiation
摘 要：In the present paper,we overview the discovery of new biological activitiesinduced by ginsenoside Rg1 and Rb1 and discuss possible mechanisms of *** compounds could increase neural plasticity in efficacy and structure;espe-cially Rg1,as one small molecular drug,can increase proliferation and differentia-tion of neural progenitor cells in dentate gyrus of hippocampus of normal adultmice and global ischemia model in *** finding has great value for treat-ment of Alzheimer’s disease and other neurodegenerative disorders which is char-acterized by neurons *** of expression of brain derived neurotrophicfactor,Bcl-2 and antioxidant enzyme,enhanced new synapse formation,inhibitionof apoptosis and calcium overload are also important neuron protective *** and Rbl have common effects,but there are some differences in pharmacol-ogy and *** differences may attribute to their different ***1 is panaxtriol with two sugars,while Rb1 is panaxtriol with foursugars.
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