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Antibacterial, cytotoxicity and wound healing assessments of amine-functionalised zeolite Y

Particuology 2019年第4期17卷 116-123页

作者： Muhammad Hariz Asraf Nik Ahmad Nizam Nik Malek Khairunadwa Jemon Nor Suriani Sani Mustapha Salisu Muhammad Department of Biosciences Faculty of Science Universiti Teknologi Malaysia 81310 Skudai Johor Malaysia Centre for Sustainable Nanomaterials (CSNano) Ibnu Sina Institute for Scientific and Industrial Research (IS1-ISIR) Universiti Teknologi Malaysia 81310 UTMJohor Malaysia Office of Deputy Vice Chancellor (Research and Innovation) Universiti Teknologi Malaysia 81310 UTM Skudai Johor Malaysia

The antibacterial activities,cytotoxicity,and wound healing of amine(3-aminopropyltriethoxysilane (APTES))-functionalised zeolite Y against normal human fibroblast cells were *** characterisation of unmodified and amine-functionalised zeolites Y (Z,ZA 0.04,ZA 0.4,and ZA 0.6) by Fourier transform infrared spectroscopy,X-ray powder diffraction,and energy dispersive X-ray analysis proved that the APTES molecules were grafted onto the zeolite Y surface without distorting its framework *** amine-functionalised zeolite Y samples possessed antibacterial activities against several ATCC bacteria that were correlated with the increased amount of APTES on the zeolite Y ***,when a higher concentration of APTES was grafted on the zeolite Y,higher cytotoxicity was observed against the fibroblast *** the ZA 0.6 sample (zeolite Y functionalised with 0.6 M of APTES) had higher antibacterial activity,it was cytotoxic to the ***,the selection of an antibacterial agent for human treatment purposes must also consider its cytotoxicity effect against human cells to ensure it is biocompatible.

关键词： Zeolite Y Amine functionalised zeolite functionalisation Antibacterial agent Cytotoxicity

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Preparation of Polymer-Functionalized Iron Oxide Nanoparti-cles and Their Biomedical Properties

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Chinese Journal of Chemistry 2013年第3期31卷 401-406页

作者： Qing Lu Daixu Wei Juan Zhou Jianrong Xu Jiejun Cheng Jun Zhu Department of Radiology Shanghai Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China National Engineering Research Center for Nanotechnology Shanghai 200241 China

Superparamagnetic iron oxide nanoparticles with narrow size distributions were successfully prepared in large scale by a facile one-pot synthetic method in the presence of hydrophilic polymers, such as polyethylene glycol dia-cid （HOOC-PEG-COOH） and poly（acrylic acid）（PAA）. The as-prepared products were investigated in detail by powder X-ray diffraction （XRD）, thermogravimetric analyses （TGA）, transmission electron microscopy （TEM）, high-resolution transmission electron microscopy （HRTEM）, dynamic light scattering （DLS）, and vibrating sample magnetometer （VSM）. The interaction between polymers and iron oxide nanoparticles was investigated using Fou-rier transform infrared spectrometry （FT-IR）. The results show that polymers can be attached onto the surface of iron oxide nanoparticle by bridging coordination and monodentate fashion, respectively. The interaction affects iron oxide nanoparticle properties significantly, such as XRD diffraction intensity, hydrodynamic diameter, isoelectric point, and saturation magnetization. Furthermore, the results of in vitro experiments indicated that iron oxide-PEG-COOH nanoparticle is more cytotoxie than iron oxide-PAA nanoparticle due to different coordinating modes.

关键词： superparamagnetic nanoparticle functionalisation coordinating mode cell cytotoxicity

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Multifunctional hydrogels for chronic wounds repairing

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Biosurface and Biotribology 2023年第4期9卷 85-100页

作者： Xiao Wang Rong Hu Lu Han Xiong Lu School of Materials Science and Engineering Key Lab of Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong UniversityChengduChina Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduChina Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmaceuticsOcean University of ChinaQingdaoChina

Because of their tissue-like mechanical performances,high biocompatibility,and adjust-able functionality,hydrogels have become increasingly attractive materials for promoting wound *** wounds include burn,diabetic,and infected *** common incision wounds,chronic wounds are more challenging to *** meet the clinical needs,multifunctional hydrogels should be fabricated and *** guide future studies on the fabrication of hydrogel-based chronic wound dressings,a review of advanced multifunctional hydrogels is *** hydrogels with advanced properties,such as antibacterial,antioxidant,bioadhesive,anti-inflammatory,and wound healing properties,that can be used for skin burn wounds and diabetic wounds are ***,the prospects of advanced hydrogels for wound healing are elaborated.

关键词： adhesive property antibacterial biomaterials biomedical application functionalisation wound healing

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