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Long-term and combined effects of N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide and fumaric acid on methane production,rumen fermentation, and lactation performance in dairy goats

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Journal of Animal Science and Biotechnology 2022年第3期13卷 852-863页

作者： Zongjun Li Xinjian Lei Xiaoxu Chen Qingyan Yin Jing Shen Junhu Yao College of Animal Science and Technology Northwest A&F UniversityYangling 712100ShaanxiChina

Background:In recent years,nitrooxy compounds have been identified as promising inhibitors of methanogenesis in ***,when animals receive a nitrooxy compound,a high portion of the spared hydrogen is eructated as gas,which partly offsets the energy savings of *** objective of the present study was to evaluate the long-term and combined effects of supplementation with N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide(NPD),a methanogenesis inhibitor,and fumaric acid(FUM),a hydrogen sink,on enteric CH4production,rumen fermentation,bacterial populations,apparent nutrient digestibility,and lactation performance of dairy ***:Twenty-four primiparous dairy goats were used in a randomized complete block design with a 2×2factorial arrangement of treatments:supplementation without or with FUM(32 g/d)or NPD(0.5 g/d).All samples were collected every 3 weeks during a 12-week feeding *** FUM and NPD supplementation persistently inhibited CH4yield(L/kg DMI,by 18.8%and 18.1%,respectively)without negative influence on DMI or apparent nutrient *** supplemented in combination,no additive CH4suppression was *** showed greater responses in increasing the molar proportion of propionate when supplemented with NPD than supplemented alone(by 10.2%vs.4.4%).The rumen microbiota structure in the animals receiving FUM was different from that of the other animals,particularly changed the structure of phylum *** milk production and serum total antioxidant capacity were improved by NPD,but the contents of milk fat and protein were decreased,probably due to the bioactivity of absorbed NPD on body ***:Supplementing NPD and FUM in combination is a promising way to persistently inhibit CH4emissions with a higher rumen propionate ***,the side effects of this nitrooxy compound on animals and its residues in animal products need further evaluation before it can be used as an animal feed additiv

关键词： Bacterial populations Dairy goat fumaric acid Lactation performance Methane emissions N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide Rumen fermentation

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The ornithine-urea cycle involves fumaric acid biosynthesis in Aureobasidium pullulans ***,a green and eco-friendly process for fumaric acid production

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Synthetic and Systems Biotechnology 2023年第1期8卷 33-45页

作者： Xin Wei Miao Zhang Guang-Yuan Wang Guang-Lei Liu Zhen-Ming Chi Zhe Chi College of Marine Life Sciences Ocean University of ChinaYushan RoadNo.5QingdaoChina Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology266003China College of Life Science Shandong Province Key Laboratory of Applied MycologyQingdao Agricultural UniversityQingdao266109China

The current petroleum chemical methods for fumaric acid production can cause heavy pollution and global *** this study,the engineered strains of *** *** were found to be suitable for green fumaric acid *** and complementation of the relevant genes showed only the ornithine-urea cycle(OUC)was involved in high level fumarate biosynthesis which was controlled by the Ca^(2+)signaling *** of both the GOX gene encoding glucose oxidase and the PKS1 gene encoding the polyketide synthase for 3,5-dihydroxydecanoic acid biosynthesis and overexpression of the PYC gene encoding pyruvate carboxylase made the strain e-PYC produce 88.1±4.3 g/L of fumarate at flask level and 93.9±0.8 g/L of fumarate during the fed-batch *** a yeast-like fungal strain,it was very easy to cultivate *** *** DH177 and their mutants in the bioreactor and to edit its genomic DNAs to enhance fumarate *** was found that 2 mol of CO_(2) could be fixed during a maximal theoretical yield of 2 mol of fumarate per mole of glucose consumed in the ***,the OUC-mediated fumarate biosynthesis pathway in *** *** was a green and eco-friendly process for the global sustainable development and carbon neutrality.

关键词： fumaric acid A.pullulans var.aubasidani Ornithine-urea cycle Ca^(2+)signaling pathway

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Syntheses and Crystal Structure of a New 3D Ag(I)-fumaric acid Framework, [Ag(hmt)(fma)_(1/2)·2H_2O]_n

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Chinese Journal of Chemistry 2003年第6期21卷 655-658页

作者：毕文华孙道峰曹荣李星时茜洪茂椿 State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China

A new silver(I) coordination polymer, [Ag(hmt)(fma) 1/2 ·2H 2O] n (1), (hmt=hexamethylenetetramine, fma=furmaric acid), was obtained by self assembly of hmt, fma and AgNO 3 in the mixed solvent of methanol, dichloromethane and water (CH 3OH∶CH 2Cl 2∶H 2O=5∶5∶1), and characterized by X ray diffraction analysis. Complex 1 belongs to orthorhombic space group Pbcn with cell parameters a =1 72043(5) nm, b = 1 19704(2) nm, c =1 11685(3) nm, V =2 30007(10) nm 3, Z =8, CCDC number: 194381. In complex 1, each hmt ligand acts as a μ 3 bridge to link three Ag(I) atoms and in turn every Ag(I) ion attaches to three hmt ligands to produce a 2D honeycomb network, which is further linked by the bidentate fma ligands to form a 3D noninterpenetrating open framework with one dimensional channels being filled by guest molecules.

关键词： fumaric acid silver polymer honeycomb layer crystal structure

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Engineering a fumaric acid-responsive two-component biosensor for dynamic range improvement in Escherichia coli

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Systems Microbiology and Biomanufacturing 2022年第3期2卷 533-541页

作者： Huiqin Yang Xiaoyan Yang Yanbo Lu Quanxian Shu Shenghu Zhou Yu Deng National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing Jiangnan University1800 Lihu RoadWuxi 214122JiangsuChina Jiangsu Provincial Research Center for Bioactive Product Processing Technology Jiangnan University1800 Lihu RoadWuxi 214122JiangsuChina Shandong Provincial Key Laboratory of Fat and Oil Deep-Processing Shandong Bohi Industry Co.LtdNo.333Binhe RoadBoxing Industrial ParkBinzhou 256599ShandongChina

Due to the selective permeability of the cytomembrane,high-yield fumaric acid strains form a steep difference between intra-and extracellular *** biosensors cannot detect the real concentration change of extracellular fumaric *** overcome this limitation,a two-component biosensor(TCB)that could respond to extracellular fumaric acid was designed based on the DcuS-DcuR two-component *** two-component system consists of a histidine kinase(SK)and response *** is a transmembrane histidine kinase sensor that can detect concentration changes in extracellular *** improve the dynamic range of the constructed fumaric acid TCB,we optimized the expression ratio and expression intensity of dcuS and *** found that the optimum expression ratio of dcuS:dcuR was 46:*** this ratio,the higher was the expression level,the greater the dynamic *** addition,we modified the ATP-binding site on the DcuS,and the final dynamic range of the TCB reached ***,the obtained fumaric acid-responsive TCB with a high dynamic range is reported for the first time,providing a synthetic biology tool for high-throughput screening and dynamic metabolic regulation of fumaric acid cell factories.

关键词： Biosensor fumaric acid Histidine kinase Response regulator Two-component system

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Oxidation of furfural to maleic acid and fumaric acid in deep eutectic solvent(DES)under vanadium pentoxide catalysis

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Journal of Bioresources and Bioproducts 2021年第1期6卷 39-44页

作者： Jingwen Shao Yong Ni Lifeng Yan CAS Key Laboratory of Soft Matter Chemistry Hefei National Laboratory for Physical Sciences at the Microscaleand Department of Chemical PhysicsiCHEMUniversity of Science and Technology of ChinaHefei 230026China

Furfural is an alternative feedstock and has been used for the production of maleic acid(MA)and fumaric acid(FA)by an oxidation *** eutectic solvents(DESs)were used as the green solvents while sodium chlorate was used as an oxidant and vanadium pentoxide was used as the catalyst at 70-90°C under atmospheric *** was found that several acidic DESs are valid,such as acetic acid/choline chloride(AA/ChCl)and propionic acid/choline chloride(PA/ChCl),and AA/ChCl DES was selected as the solvent for the *** optimal DES is AA/ChCl,and the effect of the amount of oxidant,time,and temperature on the yield of the MA and FA has been systematically studied,and the conversion of furfural can reach 100%while the yield of the MA and FA reached 66.5%under reaction temperature of 80℃ for 12 h,which provides a new green route to synthesis valuable monomers from furfural.

关键词： Furfural Maleic acid fumaric acid Deep eutectic solvent(des) Oxidation

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Study on the Mass Transfer of Supported Liquid Membrane Extraction of fumaric acid

Study on the Mass Transfer of Supported Liquid Membrane Extr...

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The 4th Joint China/Japan Chemical Engineering Symposium

作者： Shengji Li Huanlin Chen Lin Zhang?College of Materials Science and Chemical Engineering Zhejiang University Hangzhou 310027 China

As a very important raw material of organic chemistry, fumaric acid （trans-butene diacid）, hasbeen applied in many fields including food, medicine and light industry. And wastewater producedin the production process of fumaric acid exhibits low pH, high CODcr value, high thioureaconcentration and low biodegradability. Supported liquid membrane （SLM） separation is one of theliquid membrane techniques which combines extraction with stripping into one step, and has beenwidely applied in many fields including the removal and recovery of metals, gas separation,separation of organic acid, sample enrichment for trace elements and so on. Hollow fiber modulesfor SLM （HFSLM）, in particular, are widely used since it can offer higher surface area. In this study,HFSLM was used to recover fumaric acid from waste effluents and the mass transfer of the HFSLMprocess was modeled. The fumaric acid was almost completely recovered and the total TOCremoval rate was 96.5%. In the model, the effect of distribution coefficient on the overall masstransfer coefficient was considered. Under the conditions studied, and at the extraction time of 1 h,the three individual mass transfer coefficients were: kw = 8.044×10-6 m/s, km = 5.333×10-6 m/s,and ks = 1.404×10-5 m/s. And the total mass transfer coefficient calculated was Kw = 4.942×10-6m/s. The three individual mass transfer resistances were the same orders of magnitude, implyingthat the mass transfer resistance in the feed boundary layer, the diffusion resistance through themembrane and the mass transfer resistance in the stripping boundary layer all contributedsignificantly to the total mass transfer resistance over the conditions studied. The semilogarithmicplot of the dimensionless fumaric acid concentration in the feed solution was fairly linear tooperating time. And the absolute value of the slope of the line was very near to the overall masstransfer coefficient Kw. The modeling result greatly agreed with the experimental result. The effec

关键词： Supported liquid membrane SLM fumaric acid Mass transfer Extraction Hollow fiber module

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Site-directed mutagenesis and codon optimization of Rhizopus oryzae pyruvate carboxylase in combination with CO2 supplementation in fermentation broth elevate fumaric acid biosynthesis in engineered Saccharomyces cerevisiae cells

Site-directed mutagenesis and codon optimization of Rhizopus...

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第九届中国模式真菌研讨会

作者： Guoqiang Xu Yang Liu Pengyue Li Manzhen Wu Linghuo Jiang The Key Laboratory of Industrial Biotechnology Ministry of Education School of BiotechnologyJiangnan University National Engineering Laboratory for Cereal Fermentation Technology Jiangnan University School of Biotechnology Jiangnan University

Dicarboxylic acids are widely used organic acids in food,pharmaceutical and chemical *** carboxylase plays a pivotal role in production of dicarboxylic *** this study,we have constructed a synthetic pathway of fumaric

关键词： fumaric acid Saccharomyces cerevisiae pyruvate carboxylase site-saturation mutagenesis CO2

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Equilibrium of Extraction of Succinic, Malic, Maleic and fumaric acids with Trioctylamine

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Chinese Journal of Chemical Engineering 2002年第3期10卷 281-285页

作者：李振宇秦炜汪敏黄焱戴猷元 DepartmentofChemicalEngineering TsinghuaUniversityBeijing100084China

Extraction equilibrium features of succinic acid, malic acid,maleic acid and fumaric acid were investi- gated systematically withtrioctylamine (TOA) in chloroform, 4-methyl-2-pentanone (MIBK) and1-octanol. Fourier transform-infrared (FTIR) spectroscopic analysisof organic samples loaded with the acid shows that amine forms 1:1complex of ion-pair association with succinic acid, malic acid andmaleic acid, and 1:1, 2:1 complex of ion-pair association withfumaric acid. It is proposed that the complex forms depend on thesecond dissociation constant of the dibasic acid, pK_a2.

关键词： succinic acid malic acid maleic acid fumaric acid

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A 2-D Copper Coordination Polymer[Cu(4,4'-bpy)(H_(2)O)_(4)](C_(4)H_(2)O_(4))(H_(2)O)_(4)Integrated by Hydrogen Bonds and VDW Interactions

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Chinese Journal of Structural Chemistry 2004年第8期23卷 862-864页

作者： KANG Yao LI Zhao-Ji QIN Ye-Yan CHEN Yu-Biao ZHANG Jian HU Rui-Feng WEN Yi-Hang CHENG Jian-Kai YAO Yuan-Gen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterThe Chinese Academy of SciencesFuzhouFujian 350002China

The title compound, [Cu(4,4-bpy)(H2O)4](C4H2O4)(H2O)4 1, has been syn- thesized by the reaction of Cu(NO3)23H2O with 4,4-bipyridine and fumaric acid, and structurally characterized by X-ray diffraction analysis. Its crystal structure belongs to monoclinic, space group C2/c with a = 16.6350(5), b = 11.1667(2), c = 13.1371(4) ? = 125.144(1), C14H26CuN2O12, Mr = 477.91, Z = 4, V = 1995.47(9) 3, Dx = 1.591 g/cm3, m = 1.160 mm-1, F(000) = 996, R = 0.0331 and wR = 0.0883 for 1765 observed reflections (I > 2(I)). A two-dimensional network is formed in complex 1 through the hydrogen bonds and VDW interactions.

关键词： copper 4,4'-bipyridine fumaric acid a chain coordination polymer

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Metabolically based liver damage pathophysiology in patients with urea cycle disorders-A new hypothesis

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World Journal of Gastroenterology 2017年第44期23卷 7930-7938页

作者： Ivan Ivanovski Milos Jesic Ana Ivanovski Livia Garavelli Petar Ivanovski Clinical Genetics Unit Department of Obstetrics and Pediatrics AUSL-IRCCS of Reggio Emilia Department of Surgical Medical Dental and Morphological Sciences with interest in Transplant Oncology and Regenerative Medicine University of Modena and Reggio Emilia School of Medicine University of Belgrade University Children’ Hospital Faculty of Chemistry University of Belgrade

The underlying pathophysiology of liver dysfunction in urea cycle disorders(UCDs) is still largely elusive. There is some evidence that the accumulation of urea cycle(UC) intermediates are toxic for hepatocyte mitochondria. It is possible that liver injury is directly caused by the toxicity of ammonia. The rarity of UCDs, the lack of checking of iron level in these patients, superficial knowledge of UC and an underestimation of the metabolic role of fumaric acid, are the main reasons that are responsible for the incomprehension of the mechanism of liver injury in patients suffering from UCDs. Owing to our routine clinical practice to screen for iron overload in severely ill neonates, with the focus on the newborns suffering from acute liver failure, we report a case of citrullinemia with neonatal liver failure and high blood parameters of iron overload. We hypothesize that the key is in the decreased-deficient fumaric acid production in the course of UC in UCDs that causes several sequentially intertwined metabolic disturbances with final result of liver iron overload. The presented hypothesis could be easily tested by examining the patients suffering from UCDs, for liver iron overload. This could be easily performed in countries with a high population and comprehensive national register for inborn errors of metabolism. Conclusion: Providing the hypothesis is correct, neonatal liver damage in patients having UCD can be prevented by the supplementation of pregnant women with fumaric or succinic acid, prepared in the form of iron supplementation pills. After birth, liverdamage in patients having UCDs can be prevented by supplementation of these patients with zinc fumarate or zinc succinylate, as well.

关键词： Urea cycle disorder Citrullinemia Neonatal liver iron overload fumaric acid Succinic acid Krebs' cycle Transferrin Zinc fumarate supplementation

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