检索结果-南通市图书馆

检索条件"主题词=free-radical cytoprotection"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Cytoprotective effects of quercetin and its sugar-containing natural congeners in cultured HEK293 cells injured by anoxia/hypoglycemia and the struc-ture-effect relationship thereto

Cytoprotective effects of quercetin and its sugar-containing...

引用

两岸三地药理学与临床药理学术会议

作者： JIN Yue~1 LV Yong~1 HAN Guo-zhu~1 YU Hong-shan~2 JIN Feng-xie~2 (1.Department of Clinical Pharmacology,Dalian Medical University,Dalian 116044 2. Department of Foodstuffs and Bio-engineering,Dalian Polytechnology University, Dalian 116034)

Objective To comparatively study anti-free radical and cytoprotective effects of quercetin(Q)and its monoglucoside isoquercetin(I),diglucoside rutin(R),which differs only in glycosyl-substitution at C-3 position of the molecules,using anoxia/hypoglycemia-induced cell injury model and thereby to explore the structure-effect relationship *** The cell injury model was established by HEK293 cells cul- tured in vitro with NaSO plus sugar-free Earle’s fluid as incubation medium;Cell survival rate(CSR), total antioxidant capacity(TAC),SOD and LDH levels were determined;The effect intensity of the 3 flavonoids were compared by means of IC,the concentration required to achieve 50% inhibition of the changes in the above indices in injured *** Q,I and R all concentration-dependently elevated CSR, TAC and SOD,and reduced LDH level;the all of IC50s for the above indices were ranked in order of ICI>*** The 3 structurally similar flavoloids all have significant and concentration-dependent anti-free radical and cyto-protective effects with the intensity being in order of aglycone>monoglucoside>diglucoside;the substitution of-OH by sugar group at C-3 position of flavoloids and increase in the sugar-substituent number are associated with the ef- fect intensity reduced;namely,the intensity of these effects of flavonoids is negatively related the substutu- tion by sugar group at C-3 position.

关键词： quercetin isoquercetin rutin flavonoid free-radical cytoprotection cell culture

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：