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Mineralized collagen-modified PMMA cement enhances bone integration and reduces fibrous encapsulation in the treatment of lumbar degenerative disc disease

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Regenerative Biomaterials 2020年第2期7卷 181-193页

作者： Long Yang Jianjun Kong Zhiye Qiu Tieliang Shang Siyu Chen Rui Zhao Maria Grazia Raucci Xiao Yang Zhanyong Wu National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Orthopaedics Orthopaedic Hospital of XingtaiXingtai 054000China Department of Orthopedic Laboratory Xingtai Institute of OrthopaedicsXingtai 054000China Beijing Allgens Medical Science and Technology Co. LtdBeijing 102609China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Institute of Polymers Composites and BiomaterialsNational Research Council of ItalyNaples 80125Italy

As a minimally invasive surgery,percutaneous cement discoplasty(PCD)is now contemplated to treat lumbar disc degeneration disease in elder ***,we investigated whether the osteogenic mineralized collagen(MC)modified polymethylmethacrylate(PMMA)cement could be a suitable material in PCD ***,hydrophilicity and mechanical properties of the MC-modified PMMA(PMMA-MC)was *** introduction of MC did not change the application and setting time of PMMA and was easy to be handled in minimally invasive *** of PMMA-MC was greatly improved and its elastic modulus was tailored to complement mechanical performance of bone under dynamic ***,PCD surgery in a goat model with induced disc degeneration was performed with implantation of PMMA-MC or *** months after implantation,micro-computed tomography analysis revealed a 36.4%higher circumferential contact index between PMMA-MC and bone,as compared to PMMA *** staining confirmed that the surface of PMMA-MC was in direct contact with new bone,while the PMMA was covered by fibrous *** observed gathering of macrophages around the implant was suspected to be the cause of fibrous ***,the interactions of PMMA and PMMA-MC with macrophages were investigated in *** discovered that the addition of MC could hinder the proliferation and fusion of the ***,expressions of fibroblaststimulating growth factors,insulin-like growth factor,basic fibroblast growth factor and tumor necrosis factor-b were significantly down-regulated in the macrophages cocultured with ***,the promoted osteointegration and reduced fibrous tissue formation observed with PMMA-MC material makes it a promising candidate for PCD surgery.

关键词： mineralized collagen lumbar degenerative disc disease percutaneous cement discoplasty fibrous encapsulation

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