Mineralized collagen-modified PMMA cement enhances bone integration and reduces fibrous encapsulation in the treatment of lumbar degenerative disc disease

作     者：Long Yang Jianjun Kong Zhiye Qiu Tieliang Shang Siyu Chen Rui Zhao Maria Grazia Raucci Xiao Yang Zhanyong Wu 

作者机构：National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China Department of OrthopaedicsOrthopaedic Hospital of XingtaiXingtai 054000China Department of Orthopedic LaboratoryXingtai Institute of OrthopaedicsXingtai 054000China Beijing Allgens Medical Science and Technology Co.LtdBeijing 102609China School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Institute of PolymersComposites and BiomaterialsNational Research Council of ItalyNaples 80125Italy 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2020年第7卷第2期

页      面：181-193页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(grant no.81971755) Sichuan Science and Technology Innovation Team of China(2019JDTD0008) Young Elite Scientist Sponsorship Program by CAST(2019QNRC001) Fundamental Research Funds for the Central Universities,“111”Project of China(B16033) Key Research and Development Project of Heibei Province(182777172) Provincial Key Technology Support Program of Sichuan(grant no.2015SZ0027) Graduate Student’s Research and Innovation Fund of Sichuan University(Grant No.2018YJSY067) 

主　　题：mineralized collagen lumbar degenerative disc disease percutaneous cement discoplasty fibrous encapsulation 

摘      要：As a minimally invasive surgery,percutaneous cement discoplasty(PCD)is now contemplated to treat lumbar disc degeneration disease in elder ***,we investigated whether the osteogenic mineralized collagen(MC)modified polymethylmethacrylate(PMMA)cement could be a suitable material in PCD ***,hydrophilicity and mechanical properties of the MC-modified PMMA(PMMA-MC)was *** introduction of MC did not change the application and setting time of PMMA and was easy to be handled in minimally invasive *** of PMMA-MC was greatly improved and its elastic modulus was tailored to complement mechanical performance of bone under dynamic ***,PCD surgery in a goat model with induced disc degeneration was performed with implantation of PMMA-MC or *** months after implantation,micro-computed tomography analysis revealed a 36.4%higher circumferential contact index between PMMA-MC and bone,as compared to PMMA *** staining confirmed that the surface of PMMA-MC was in direct contact with new bone,while the PMMA was covered by fibrous *** observed gathering of macrophages around the implant was suspected to be the cause of fibrous ***,the interactions of PMMA and PMMA-MC with macrophages were investigated in *** discovered that the addition of MC could hinder the proliferation and fusion of the ***,expressions of fibroblaststimulating growth factors,insulin-like growth factor,basic fibroblast growth factor and tumor necrosis factor-b were significantly down-regulated in the macrophages cocultured with ***,the promoted osteointegration and reduced fibrous tissue formation observed with PMMA-MC material makes it a promising candidate for PCD surgery.