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Histopathological and imageological studies on clinical outcomes of mineralized collagen reconstruction rod for femoral head necrosis with one case report

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Regenerative Biomaterials 2017年第4期4卷 243-249页

作者： Baogang Xie Hao Wang Jianhua Hao Ping Wang Na Zhang Jingjing Wu Zhiye Qiu Fuzhai Cui Department of Orthopaedics 254th Hospital of PLANo.60 Huangwei RoadHebei DistrictTianjin 300142China School of Materials Science and Engineering Tsinghua UniversityHaidian District Beijing 100084China

In this article,the biodegradation process and bone formation of a mineralized collagen reconstruction rod embedding in necrosis of human femoral head were investigated by imageological and histological *** radiography(CR)computerized tomography(CT),common pathological section and hard tissue section analysis were used to evaluated the dynamics of imageological and histopathological changes of femoral head,interface between the host bone and implant and the bone reconstruction *** results showed that the density of rods increased closed to that of host bones after 1 year implanting,and the interface between them turns to *** tissue grinding sections analysis showed osteocytes appearing in sparse bone trabecular and bone pit region,as well as a few vessels in the degraded dye powder matrix were noticed,indicating the new bone forming between the implants and host *** decalcified sections analysis showed scattered osteoclasts,multinucleated giant cells and fibrosis components existing in the degraded rod and the host bone *** debris was endocytosed by giant cells,and vascular network formed around the boundaries of the implanted *** good osteointegration has been expressed by the interface between the implanted rod and the host bone becoming *** results indicated that the implanted rod degradation process and new bones regeneration simultaneously occurred around the boundaries of embedding *** bone and host bone were hinged and co-existed.

关键词： femoral head necrosis mineralized collagen reconstruction rod for femoral head necrosis

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Primary repair for concurrent bilateral intertrochanteric fracture and femoral head necrosis with prolonged shank biologic total hip replacement: A case report and surgical techniques

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Chinese Journal of Traumatology 2023年第3期26卷 183-186页

作者： Yuan-Jie Liu Jun-Tan Li Yu-Yang Gao Pei-Yan Guo Tian-Xu Dou Xu Li Department of Orthopedics The First Hospital of China Medical UniversityShen Yang110000China

For the treatment of an intertrochanteric fracture combined with femoral head necrosis in middle-age patients,it has been controversial whether to perform fracture reduction and fixation first then total hip replacement,or direct total hip *** present a rare case of 53-year-old male patient suffered from bilateral intertrochanteric fracture caused by a road traffic *** patient had a history of femoral head necrosis for eight years,and the Harris score was *** performed total hip replacement with prolonged biologic shank prostheses for primary *** year after the surgery,nearly full range of motion was achieved without instability(active flexion angle of 110°,extension angle of 20°,adduction angle of 40°,abduction angle of 40°,internal rotation angle of 25°,and external rotation angle of 40°).The Harris score was *** the middle-aged patient with unstable intertrochanteric fractures and osteonecrosis of the femoral head,we can choose primary repair for concurrent bilateral intertrochanteric fracture and femoral head necrosis with prolonged shank biologic total hip replacement.

关键词： Bilateral Primary hip replacement femoral head necrosis Intertrochanteric fracture Greater trochanteric plate

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Total hip arthroplasty for treatment of elderly patients with comminuted intertrochanteric fracture accompanied by femoral head necrosis

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Chinese Journal of Traumatology 2008年第6期11卷 359-363页

作者：刘先哲杨闻杨述华许伟华叶树楠 Department of Orthopedics Union Hospital of TongjiMedical College of Huazhong University of Science andTechnology Wuhan Hubei 430022 China

Objective： To assess the curative effect and investigate the indications of total hip arthroplasty for treatment of comminuted intertrochanteric fractures. Methods： Total hip arthroplasty was carried out in 9 cases of severe intertrochanteric fracture. The patients included two men and seven women. The average age of the patients was 68 years （48-75 years）. The period from fracture to operation was 5 days （2-10 days）. The mean follow- up period lasted for 11 months （3 months-2 years）. There was one patient with comminuted intertrochanteric fracture accompanied by femoral head necrosis and 2 patients with intertrochanteric fracture and stroke. Other 6 patients had severe osteoporosis. The Harris score before operation was 63 points （45-71 points）.Results： At the last follow-up, the patients gained 86points （70-100 points） according to the Harris score. The effects of the 8 cases were good. The Harris score of all patients improved after treatment. Only two hemiplegia patients needed sticks to walk. The others could walk without hip pain. No radiographic evidence of acetabular wear and prosthesis dislocation or other major complications happened during the follow-up. Conclusions： Prosthetic replacements can well treat unstable intertrochanteric fracture if operative indication is correctly selected. It is suitable for elderly patients and the operation should be performed by experienced surgeons.

关键词： Hip fractures Arthroplasty femoral head necrosis

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Can hip abduction reduce the risk of femoral head necrosis deteriorated into osteoarthritis?A 3D finite element analysis

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Traditional Medicine Research 2018年第5期3卷 230-236页

作者： Guang-Quan Zhou Hong-Lai Zhang The First Affiliated Hospital Guangzhou University of Chinese MedicineGuangzhouChina School of Medical Information Engineering Guangzhou University of Chinese MedicineGuangzhouChina

The purpose of this study was to investigate biomechanical behavior changes of femoral head necrosis(FHN)by increasing lower extremity abduction(LEA)angle,offering scientific basis on choosing the LEA procedure for the exact ***:Thirty computational models were constructed and used to simulate six different abducent angles with five different progresses of *** initial model was validated by the bony density distribution in X-rays images and the photograph of the cadaver bone in *** stress transfer path(STP)of each model was analyzed and the contact stresses were ***:During the midstance phase,STP of type A showed strong similarities with the healthy level;STP distribution was from the top of the femoral head to the calcar;the damage area of STP of type B was approximately 25%of the *** STPs in both type C1 and C2 were broken *** the increase of the abduction angle,STP of type B transformed into type A,STP of type C1 transformed into type *** of type C2 transformed into type *** was no significant difference in contact stress between the four settings of FHN and normal femoral ***:We found computational biomechanical technique to be a sensitive and useful method for distinguishing the biomechanical difference of FHN during abduction *** results showed that LEA motion could effectively reduce collapse risk and interrupt the disease pathway of FHN deteriorated into ***,our findings indicated that the LEA procedure was suitable for type A,B and C1,while type C2 of FHN involved surgical intervention might get a better clinical outcome.

关键词： Lower extremity abduction Contact stress femoral head necrosis Stress transfer path Osteoarthritis Computational biomechanics

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Endoplasmic Reticulum Stress Affected Chondrocyte Apoptosis in femoral head necrosis Induced by Glucocorticoid in Broilers

Endoplasmic Reticulum Stress Affected Chondrocyte Apoptosis ...

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2019中国畜牧兽医学会兽医外科学分会第十届会员代表大会暨第24次学术研讨会

作者： Min Zhang Suwan Li Kaiyi Pang Zhenlei Zhou College of Vet Med Nanjing Agricultural University

In our previous study,chondrocyte apoptosis in femoral head necrosis(FHN)-affected broilers was found to be associated with the endoplasmic reticulum stress(ERS) signaling *** the present study,we further explored the role of ERS-induced chondrocyte apoptosis in FHN-affected broilers and the parallel test was carried outwith articular chondrocytescultivated in *** broilers and chondrocytes were treated with methylprednisolone(MP).The main pathological changes in FHN-affected broilers included the proximal femoralhead separated from its articular cartilage and growthplate ***-treated chondrocytes demonstrated morphology changes,cell viability reduction,secretory capacity dysfunction,and *** mRNA expressions of pro-apoptotic genes controlled by ERS signaling pathway were up-regulated both in vivo and in vitro *** showed that MP induced FHN in broilers,activated apoptosis-related genes on ERS signaling

关键词： femoral head necrosis endoplasmic reticulum stress apoptosis chondrocyte broiler

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Deproteinized bone with VEGF gene transfer to facilitate the repair of early avascular necrosis of femoral head of rabbit

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Chinese Journal of Traumatology 2009年第5期12卷 -页

作者： CAO Kai HUANG Wei AN Hong JIANG Dian-ming SHU Yong HAN Zhi-min Department of Orthopedics First Affiliated Hospital Nanchang University Nanchang 330006 China Department of Orthopedics First Affiliated Hospital Chongqing University of Medical Sciences Chonqing 400016 Chongqing China

Objective: To explore a new method for early avascular necrosis of femoral head (AVNFH) ***: Sixty-nine AVNFH New Zealand adult rabbits were randomly divided into three groups with equal number. In Group A, deproteinized bone (DPB) that absorbed with recombinant plasmid pcDNA3.1-hVEGF165 was implanted into the drilled tunnel of necrotic femoral head. In Group B, only DPB was implanted. In Group C, only tunnel was drilled without DPB or plasmid implanted. femoral head specimens were obtained at postoperative 1, 2, 4, 8, 16 weeks. The expression of VEGF165 and collagen I was detected by immunohistochemistry. Bone formation was detected generally by X-ray. Angiogenesis and the repair of the femoral head were observed ***: The expression of VEGF 165 could be detected 2 weeks after implantation in Group A, but it was not observed in other groups. The result of collagen I expression had a significantly difference 2, 4 and 8 weeks after operation in Group A from those in other groups (P＜0.01).X-ray results indicated that there was more bone formation in Group A than in other groups. The regenerated capillary vessels staining result of necrotic femoral head in Group A was significantly different from those in other groups at postoperative 2 and 4 weeks (P＜0.01).Conclusions: Transfection ofhVEGF165 gene enhances local angiogenesis and DPB-VEGF compound improves the repair of necrotic femoral head. Deproteinized bone grafting with VEGF gene transfer provides a potential method for the treatment of osteonecrosis.

关键词： Vascularendothelialgrowthfactor Gene therapy femoral head necrosis

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An Experimental Study of Pathogenesis of Steroid-induced Avascular necrosis of femoral head

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Journal of Nanjing Medical University 2003年第4期17卷 191-195页

作者：李毅陈君长康斌王坤正张珍妮同志超西安交通大学第二临床医院骨科西安交通大学第二临床医院消化科

Objective: To explore the pathogenesis of avascular necrosis of femoral head(ANFH) and search an effective method for clinical practice. Methods: Twenty-four Japanese rabbitswere divided into 2 groups of models and controls. ANFH models were produced byintramuscular-injection of large dosage of steroid to rabbits for 8 weeks. From the 4th, 8th and12th week after production of models, 2 rabbits of each group were sacrificed to observe thestructure of femoral head through light microscope and scanning electron microscope. The contents ofNitric Oxide (NO), tissue-type plasminogen activator (t-PA) and -plasminogen activator inhibitor(PAI) in plasma of the 4 rabbits in each group were estimated at the same time. Results: Comparedwith control group, the rabbits of model group exhibited many differences: such as osteoporosis offemoral head, the presence of more bone lacuna and fat cell through light microscope observing; thebroken and sunk bone trabecula, the loosen and broken collagen fibers on the surface of bone matrixthrough scanning electron microscope observing. Compared with control group, the Concentration ofNO and t-PA in plasma of the model rabbits decreased obviously, but the Concentration of the PAIincreased obviously. Conclusion: The steroid-induced ANFH might be related to the lower level of NOand the descent of fibrinolytic activity.

关键词： femoral head necrosis pathological process nitric oxide tissue-typeplasminogen activator plasminogen activator inhibitor

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Taohong Siwu Decoction:a classical Chinese prescription for treatment of orthopedic diseases

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Chinese Journal of Natural Medicines 2024年第8期22卷 711-723页

作者： SHI Yunzhen WANG Shengpeng DENG Disi WANG Yitao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoMacao SAR 999078China Gynaecology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611137China Clinical Medical College Chengdu University of Traditional Chinese MedicineChengdu 610075China

The pathogenesis of orthopedic diseases is intimately linked to blood stasis,frequently arising from damage to primary and secondary blood *** disruption can lead to“blood leaving the meridians”or Qi stagnation,resulting in blood stasis *** Siwu Decoction(THSWD)is a renowned classical Chinese medicinal formula extensively used to promote blood circulation and mitigate blood *** studies have demonstrated its significant therapeutic effects on various orthopedic conditions,particularly its anti-inflammatory and analgesic properties,as well as its efficacy in preventing deep vein thrombosis *** these findings,research on THSWD remains fragmented,and its interdisciplinary impact is *** review aims to provide a comprehensive evaluation of the efficacy and pharmacological mechanisms of THSWD in treating common orthopedic ***,we employ bibliometric analysis to explore research trends and hotspots related to *** hope this review will enhance the recognition and application of THSWD in orthopedic treatments and guide future research into its pharmacological mechanisms.

关键词： Taohong Siwu Decoction Classical prescriptions Orthopedic diseases Fracture femoral head necrosis Joint replacement

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The changes of nitric oxide and hemorheology in steroid-induced avas-cular necrosis of femoral head

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Journal of Medical Colleges of PLA(China) 2006年第2期21卷 108-111页

作者：王国毓贺西京李毅张珍妮 Department of Orthopedics Second HospitalXi'an Jiaotong UniversityXi'an 710004China

Objective: To explore the pathogenesis of avascular necrosis of femoral head (ANFH), the early diagnosis index and the treatment effective index of ANFH in clinical practice. Methods: Twenty-four Japanese rabbits were divided into 2 groups: model group and control group. ANFH models were produced by intramuscular injection of large dosage of steroid to rabbits for 8 weeks. On the 4 th, 8 th week after the injection, two rabbits each time from each group were taken to observe the structure of femoral head by light microscope and scanning electron microscope. Four other stomach-empty rabbits from each group were also used to test the contents of Nitric Oxide (NO), contents of the hemorheology indexes. Results: Compared with the control group, the rabbits in the model group exhibited osteoporosis of femoral head and more bone lacuna and more fat cells through light microscope. Through scanning electron microscope observation bone trabecula were broken and sunk, and collagen fibers on the surface of bone matrix became loosen and broken, more osteocyte had pyknosis, adipocyte in the medullary cavity were enlarged and subchondral arterioles and capillaries of the femoral head were pressed by adipocyte. Compared with the control group, the model rabbits contained less NO and obvious increase of the plasma viscosity (PV), low blood viscosity (LBV), erythrocyte hematocrit (HCT), indices of erythrocyte rigidity (TK) and indices of erythrocyte aggregation (AI), plasma fibrin level (PFL) (P<0. 01) and an increase of erythrocyte electrophoresis rate (ERT) (P< 0.05). High blood viscosity (HBV), and erythrocyte sedimentation rate (ESR) were unchanged. Conclusion: The steroid-induced ANFH might be related to less NO and the abnormal hemorheology; and NO and hemorheology should be considered as an early diagnosis index for ANFH in clinical practice.

关键词： femoral head necrosis pathology nitric oxide hemorheology early diagnosis index

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Multivariate Analysis of femoral Adductor Muscle Contracture after Total Hip Arthroplasty in Patients with Avascular necrosis of femoral head

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Journal of Clinical and Nursing Research 2020年第6期4卷 1-7页

作者： Lin Meng Dong Zhang Qing Wei Xinli Zhan Jinhong Cai Hongyu Li Joint Surgery Guangxi Orthopaedics and Traumatology Hospi talNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Spine and Osteopathy Ward the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China

Objective:This study is to investigate the nisk factors of femoral head contracture after total hip arthroplasty(THA)in patients with avascular necrosis of femoral ***:Retrospective analysis was perfomed in 361 cases of femoral head necrosis patients taking THA fom September 2016 to December 2017.A total of 179 patents with no significant preoperative adductor muscle contraction were finally enrolled in this *** 179 patients were further divided into two groups:contracture group(64 cases)and noncompaction group(115 cases).The chi-square test was used to compare the differences between the two *** factors were identifed by logistic regession ***:of the patients included,64 patients (35.75%)developed into end adductor muscle *** were signuificant differences in limb *** history,whether taction,surgical approach,surgical methods,and fumctional training between the two goups(Pfemoral head contracture after THA in patients with avascular necrosis of femoral ***:Preoperative traction therapy,surgical methods,and postoperative functional training are the factors that affect the adductor muscle contraction after THA.

关键词： femoral head necrosis Total hip arthroplasty,Risk factors,Multivariate analysis

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