Endoplasmic Reticulum Stress Affected Chondrocyte Apoptosis in Femoral Head Necrosis Induced by Glucocorticoid in Broilers
作者单位：College of Vet MedNanjing Agricultural University
会议名称：《2019中国畜牧兽医学会兽医外科学分会第十届会员代表大会暨第24次学术研讨会》
会议日期：2019年
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
关 键 词：femoral head necrosis endoplasmic reticulum stress apoptosis chondrocyte broiler
摘 要：In our previous study,chondrocyte apoptosis in femoral head necrosis(FHN)-affected broilers was found to be associated with the endoplasmic reticulum stress(ERS) signaling *** the present study,we further explored the role of ERS-induced chondrocyte apoptosis in FHN-affected broilers and the parallel test was carried outwith articular chondrocytescultivated in *** broilers and chondrocytes were treated with methylprednisolone(MP).The main pathological changes in FHN-affected broilers included the proximal femoralhead separated from its articular cartilage and growthplate ***-treated chondrocytes demonstrated morphology changes,cell viability reduction,secretory capacity dysfunction,and *** mRNA expressions of pro-apoptotic genes controlled by ERS signaling pathway were up-regulated both in vivo and in vitro *** showed that MP induced FHN in broilers,activated apoptosis-related genes on ERS signaling