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THE EVOLUTION OF FIELD DEPLOYABLE fnir SPECTROSCOPY FROM BENCH TO CLINICAL SETTINGS

Journal of Innovative Optical Health Sciences 2011年第3期4卷 239-250页

作者： KURTULUS IZZETOGLU HASAN AYAZ ANNA MERZAGORA MELTEM IZZETOGLU PATRICIA ASHEWOKIS SCOTT CBUNCE KAMBIZ POURREZAEI ARYE ROSEN BANU ONARAL School of Biomedical Engineering Science&Health Systems 3141 Chestnut Street PhiladelphiaPA 19104USA College of Nursing and Health Professions Drexel University PhiladelphiaPAUSA Center for Emerging Neurotechnology and Imaging&Department of Psychiatry Penn State College of Medicine HersheyPAUSA

In the late 1980s and early 1990s,*** Chance and his colleagues,using picosecond-long laser pulses,spearheaded the development of time-resolved spectroscopy techniques in an effort to obtain quantitative information about the optical characteristics of the *** efforts by Chance and colleagues expedited the translation of near-infrared spectroscopy(NIRS)-based techniques into a neuroimaging modality for various cognitive *** in the early 2000s,*** Chance guided and steered the collaboration with the Optical Brain Imaging team at Drexel University toward the development and application of afield deployable continuous wave functional near-infrared spectroscopy(fnir)system as a means to monitor cognitive functions,particularly during attention and working memory tasks as well as for complex tasks such as war games and air tra±c control scenarios performed by healthy volunteers under operational ***,these collaborative efforts led to various clinical applications,including traumatic brain injury,depth of anesthesia monitoring,pediatric pain assessment,and braincomputer interface in *** this paper,we introduce how these collaborative studies have made fnir an excellent candidate for specified clinical and research applications,including repeated cortical neuroimaging,bedside or home monitoring,the elicitation of a positive effect,and protocols requiring ecological *** paper represents a token of our gratitude to *** Chance for his influence and *** this manuscript we show our appreciation by contributing to his commemoration and through our work we will strive to advance thefield of optical brain imaging and promote his legacy.

关键词： Functional near-infrared spectroscopy fnir TBI anesthesia BCI pediatric pain

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New Application, Development and Aerospace Prospect of fnir

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Engineering（科研） 2013年第5期5卷 47-52页

作者： Jinjin Pan Xuejun Jiao National Key Laboratory of Human Factor Engineering China Astronaut Research and Training Centre Beijing China

Functional near-infrared imaging (fnir) is a non-invasive, convenient, safe and stable imaging method to test biological state. It can obtain the biological tissue hemodynamic data, thus becoming a powerful tool to measure brain activities, mental workload, metabolism and cognitive activities state. First of all, we introduced the characteristics and current situation of fnir in this article. Then we focused on the applications of fnir, discussed some existing problems and future directions, including the prospect in aerospace field. Our purpose is to give a comprehensive description of fnir and show its potential in aerospace field.

关键词： fnir Brain Activity Hemodynamics Neuro-imaging Technology

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FUNCTIONAL NEAR-INFRARED SPECTROSCOPY-BASED ASSESSMENT OF ATTENTION IMPAIRMENTS AFTER TRAUMATIC BRAIN INJURY

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 251-260页

作者： ANNA C.MERZAGORA MARIA T.SCHULTHEIS BANU ONARAL MELTEM IZZETOGLU School of Biomedical Engineering Science and Health Systems Drexel University PhiladelphiaPAUSA Department of Psychology Drexel University PhiladelphiaPAUSA

A frequent consequence of traumatic brain injury(TBI)is cognitive impairment,which results in significant disruption of an individual's everyday *** date,most clinical rehabilitation interventions still rely on behavioral observation,with little or no quantitative information about physiological changes produced at the brain *** brain imaging has been extensively used in the study of cognitive impairments following ***,its applications to rehabilitation have been *** is due in part to the expensive or invasive nature of these *** objective of this study is to apply functional near-infrared spectroscopy(fnir)to the assessment of attention impairments following *** provides a localized measure of prefrontal hemodynamic activation,which is susceptible to TBI,and it does so in a noninvasive,affordable and wearable way,thus partially overcoming the limitations of other *** included 5 TBI subjects and 11 healthy *** activation measurements were collected during a target categorization *** differences were found in the hemodynamic response between healthy and TBI *** particular,the elicited responses exhibited reduced amplitude in the TBI ***,the results providefirst evidence of the ability of fnir to reveal differences between TBI and healthy subjects in an attention *** is therefore a promising neuroimaging technique in thefield of *** use of fnir in neurorehabilitation applications would benefit from its noninvasiveness and cost-effectiveness and the neurophysiological information obtained through the evaluation of the hemodynamic activation could provide invaluable information to guide the choice of intervention.

关键词： fnir attention traumatic brain injury NIRS TBI

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基于fnirS技术探究五禽戏对儿童抑制控制的影响

基于fNIRS技术探究五禽戏对儿童抑制控制的影响

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第三届“全民健身科学运动”学术交流大会

作者：郝童童北京体育大学中国武术学院

研究目的:抑制控制是人面对无关因素和优势反应主动克服的过程,我国儿童存在学习注意力涣散、多动等问题,身体锻炼能有效提高儿童抑制控制功能。五禽戏是中华传统导引养生功法,它通过对虎、鹿、熊、猿、鸟的模仿,达到健身康养之效。其... 详细信息

研究目的:抑制控制是人面对无关因素和优势反应主动克服的过程,我国儿童存在学习注意力涣散、多动等问题,身体锻炼能有效提高儿童抑制控制功能。五禽戏是中华传统导引养生功法,它通过对虎、鹿、熊、猿、鸟的模仿,达到健身康养之效。其动静相济、松弛有度,与动作、意识和呼吸结合,注意力放在动作上,主动控制、排除杂念。鉴于有关五禽戏促进抑制控制效应和脑机制变化的研究罕见,本研究使用近红外脑成像（f NIRS）技术研究20周五禽戏锻炼干预对儿童抑制控制的影响及其发生机制。该研究假设五禽戏能提高儿童抑制控制功能,且提高效益与前额叶皮层的神经激活相关。研究方法:选择60名儿童作为实验对象,年龄9.62±2.11,五禽戏干预组和对照组各30人。自变量1是实验条件包含干预组、对照组;自变量2是测试次序,包含实验前测、后测。因变量是有一致和不一致条件的Stroop任务反应时和fnirS氧合血红蛋白变化。干预组每周3次集中锻炼,持续20周,每次75min,对照组按照原有生活方式,不做改变。测试受试者斯特鲁普效应,当受试者对汉字颜色做出反应却忽略汉字意义,一致条件为汉字颜色与意义相符,不一致条件为汉字颜色与意义不符。在不一致条件下,受试者判断速度下降,出错率提高。f NRIS技术使用NIRSport系统监测受试者进行Stroop任务测试时前额叶氧合血红蛋白变化。f NIRS数据分析:考虑因头动、呼吸等引起噪音,排除频率＞0.1Hz和频率＜0.01Hz成分,再记录受试者执行一致和不一致任务时的氧合血红蛋白变化,运用SPSS统计对氧合血红蛋白信号分析,依托配对t检验对氧合血红蛋白与原始β值进行数据分析,筛选出显著性差异通道。研究结果:Stroop一致任务中,五禽戏干预组的九个通道的氧合血红蛋白浓度明显高于对照组,其前测与后测有显著性差异,t=3.14,P=0.021;前测反应时682.01±150.87大于后测反应时624.78±144.92;对照组前测与后测无无显著性差异,t=1.039,P=0.315。Stroop不一致任务中,干预组的CH4氧合血红蛋白浓度上升,t=3.451,P=0.003,与之对应的是左背外侧前额叶。干预组前测与后测间的有显著性差异,t=3.91,P=0.023;前测反应时801.21±121.3大于后测反应时755.13±102.85;对照组前测与后测无显著性差异,t=0.913,P=0.502。研究结论:儿童的Stroop任务行为表现经过20周五禽戏锻炼得到明显提高,显著增强了五个脑区在不同条件下的神经激活水平,研究结果为五禽戏锻炼儿童抑制控制功能提供新思考和科学依据。

关键词：五禽戏 fnir 运动干预 Stroop 抑制控制

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老年人步行的大脑皮层激活研究进展

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中国运动医学杂志 2023年第8期42卷 665-672页

作者：黄文琴廖八根李文静项明强广州体育学院运动与健康学院广州510500

步行是一个高度进化和自动化的过程,同时又受到大脑高阶认知的影响。然而,随着年龄的增长,步行的自动性降低,受大脑高阶认知的影响增强。研究者采用功能性磁共振成像(functional magnetic resonance imaging,fMRI)技术和功能性近红外光... 详细信息

步行是一个高度进化和自动化的过程,同时又受到大脑高阶认知的影响。然而,随着年龄的增长,步行的自动性降低,受大脑高阶认知的影响增强。研究者采用功能性磁共振成像(functional magnetic resonance imaging,fMRI)技术和功能性近红外光谱(functional near-infrared spectroscopy,fnirS)等技术来探究老年人在想象步行和实际步行时大脑皮层的激活机制。fMRI研究发现,在想象步行时,老年人的前额叶、辅助运动区、感觉运动区等脑区激活水平比年轻人高;fnirS研究发现,在实际步行时,老年人的年龄、步行速度、步行方式以及伴随越障、言语流利和算数等双任务对大脑PFC等脑区激活产生了影响,大脑皮层的激活模式变得更加复杂。未来的研究应结合多学科方法,运用多模态脑成像技术,并详细描述实验和数据处理方法,以深入探索老年人步行的认知神经机制。在此基础上,可以利用相关的脑源性参数来开发认知领域的运动处方,以改善老年人的认知功能和步行表现。

关键词：步行想象步行大脑皮层激活 fnir fMRI

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Monitoring Mental Fatigue in Analog Space Environment Using Optical Brain Imaging

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Engineering（科研） 2013年第5期5卷 53-57页

作者： Xuejun Jiao Jing Bai Shanguang Chen Qijie Li National Laboratory of Human Factors Engineering China Astronaut Research and Training Centre Beijing China Tsinghua University Beijing China Tsinghua University Beijing China National Laboratory of Human Factors Engineering China Astronaut Research and Training Centre Beijing China

Accurate assessment of mental fatigue level would improve operational safety and efficacy of astronauts for long-term space flight. Identification of neurophysiological markers can index impending overload or fatigue before performance decrements using neuroimaging technologies. The current study utilized functional near-infrared spectroscopy (fnir) to investigate the relationship of hemodynamic response in prefrontal cortex with changes of mental fatigue level, task performance (reaction time) during n-back working memory task and routine work task in analog space environment. Results indicated that the information entropy of hemodynamic response is related to task performance and subjective self-reported measures;the reaction time is predicted by regression analysis;and the accuracy of mental fatigue classification approaches 90%. Since fnir is a portable, wearable and minimally intrusive methodology, it has the potential to be deployed in future space environments to monitoring mental fatigue and assessing the effort of operators in field environments.

关键词： Mental Fatigue Information Entropy Modeling fnir

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