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Paradoxical Roles of il-4 in Tumor Immunity

Cellular & Molecular Immunology 2009年第6期6卷 415-422页

作者： Zhiguang Li Lin Chen Zhihai Qin National Laboratory of Biomacromolecules China-Japan Joint Laboratory of Structural Virology and ImmunologyInstitute of BiophysicsChinese Academy of SciencesBeijingChina National Laboratory of Biomacro-molecules China-Japan Joint Laboratory of Structural Virology and ImmunologyInstitute of BiophysicsChinese Academy of SciencesBeijingChina

Interleukin(il)-4 is a crucial cytokine in tumor *** the initial murine experiments,il-4 exhibited potent anti-tumor *** genetically modified to produce il-4 were rejected,while parental tumors grew *** rejected il-4-producing tumors got long-lasting anti-tumor *** comparative study showed that il-4 induced the most effective immune response among several cytokines in both prophylactic and therapeutic *** of these indicate il-4 has strong potential as a tumor therapy ***,contrary evidence indeed exists,and is becoming more and more abundant which shows il-4 is a tumor-promoting ***-4 amounts are usually elevated in human cancer ***-4 knockout mice are more resistant to tumor challenge than il-4 competent ***,tumor cells of various histological origins often express increased levels of il-4 receptor in comparison to their normal *** carefully examining presently available data,we found the effects of il-4 in tumor immunity are closely related to its sources,expressing time and dose,as well as the molecular and cellular *** this mini-review,we concentrate on illustrating the paradoxical roles and underlying mechanisms of il-4 in tumor immunity and try to understand how one molecule has opposite effects.

关键词： endogenous il-4 exogenous il-4 tumor immunity

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