Paradoxical Roles of IL-4 in Tumor Immunity

作     者：Zhiguang Li Lin Chen Zhihai Qin 

作者机构：National Laboratory of BiomacromoleculesChina-Japan Joint Laboratory of Structural Virology and ImmunologyInstitute of BiophysicsChinese Academy of SciencesBeijingChina National Laboratory of Biomacro-moleculesChina-Japan Joint Laboratory of Structural Virology and ImmunologyInstitute of BiophysicsChinese Academy of SciencesBeijingChina 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2009年第6卷第6期

页      面：415-422页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by Chinese Academy of Sciences(KSCX2-YW-R-42) National Natural Science Foundation of China(30771972 and 30700287) Ministry of Science and Technology of China(2006CB504304,2006CB910901,and 2009CB918900) Ministry of Education,Culture,Sports,Science and Technology(MEXT)of Japan 

主　　题：endogenous IL-4 exogenous IL-4 tumor immunity 

摘      要：Interleukin(IL)-4 is a crucial cytokine in tumor *** the initial murine experiments,IL-4 exhibited potent anti-tumor *** genetically modified to produce IL-4 were rejected,while parental tumors grew *** rejected IL-4-producing tumors got long-lasting anti-tumor *** comparative study showed that IL-4 induced the most effective immune response among several cytokines in both prophylactic and therapeutic *** of these indicate IL-4 has strong potential as a tumor therapy ***,contrary evidence indeed exists,and is becoming more and more abundant which shows IL-4 is a tumor-promoting ***-4 amounts are usually elevated in human cancer ***-4 knockout mice are more resistant to tumor challenge than IL-4 competent ***,tumor cells of various histological origins often express increased levels of IL-4 receptor in comparison to their normal *** carefully examining presently available data,we found the effects of IL-4 in tumor immunity are closely related to its sources,expressing time and dose,as well as the molecular and cellular *** this mini-review,we concentrate on illustrating the paradoxical roles and underlying mechanisms of IL-4 in tumor immunity and try to understand how one molecule has opposite effects.