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Tojapride Reverses esophageal epithelial Inflammatory Responses on Reflux Esophagitis Model Rats

Chinese Journal of Integrative Medicine 2021年第8期27卷 604-612页

作者： YIN Xiao-lan ZHONG Linda LIN Cheng-yuan SHI Xiao-shuang ZHANG Jiao CHEN Zheng-yi CHE Hui MA Xiang-xue TIAN Ya-xin DUAN Yuan-zhi LU Lin Jl Hai-jie ZHAO Ying-pan TANG Xu-dong WANG Feng-yun Department of Gastroenterology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong Special Administrative RegionKowloonChina Department of Gastroenterology Changping Hospital of Traditional Chinese MedicineBeijing102200China Department of Traditional Chinese Medicine Dongfeng General HospitalShiyanHubei Province442000China Center of Clinical Pharmacology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China

Objective To investigate the mechanism of Tojapride,a Chinese herbal formula extract,on strengthening the barrier function of esophageal epithelium in rats with reflux esophagitis(RE).Methods Ten out of 85 SD rats were randomly selected as the sham group(n10),and 75 rats were developed a reflux esophagitis model(RE)by the esophageal and duodenal side-to-side *** successful modeling rats were divided into different medicated groups through a random number table including the model,low-,medium-,and high-dose of Tojapride as well as omeprazole groups(n10).Three doses of Tojapride[5.73,11.46,22.92 g/(kg•d)]and omeprazole[4.17 mg/(kg•d)]were administrated intragastrically twice daily for 3 *** the rats in the sham and model groups were administered 10 mL/kg distilled *** fluid was collected and the supernatant was kept to measure for volume,pH value and *** tissues were isolated to monitor the morphological changes through hematoxylin-eosin(HE)staining,and esophageal epithelial ultrastructure was observed by transmission electron *** expressions of nuclear factor kappa-light-chain-enhancer of activated B cells p65(NF-KBp65),κB kinase beta(IKKß),occludin,and zonula occludens-1(ZO-1)in the esophageal tissues were measured by immunohistochemistry and Western blot,*** The gastric pH value in the model group was significantly lower than the sham group(Pesophageal mucosa from the model rats,while varying degrees of congestion and partially visible erosion was observed in the remaining *** increase in cell gap width and decrease in desmosome count was seen in RE rats and the effect was reversed by Tojapride *** with the sham group,the IKKßlevels were significantly higher in the model group(P<0.0

关键词： reflux-esophagitis tojapride esophageal epithelial barrier anti-inflammatory

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NF-κB: A novel therapeutic pathway for gastroesophageal reflux disease?

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World Journal of Clinical Cases 2022年第24期10卷 8436-8442页

作者： Mao-Lin Zhang Long-Qing Ran Meng-Jun Wu Qin-Chen Jia Zhi-Ming Qin Yong G Peng Department of Thoracic and Cardiovascular Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Anesthesia Chengdu Women's and Children's Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610019China Thoracic and Cardiovascular Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States

Although gastroesophageal reflux disease(GERD),a common chronic disease in clinical practice,has been widely studied,its potential adverse impact on patients is still a significant clinical *** is necessary to understand the pathogenesis of the disease and choose appropriate treatment according to its *** pathogenesis of GERD is diverse and *** the traditional treatment methods are expensive and ineffective in alleviating symptoms in some patients,new treatment options need to be *** previous study suggested that the activation of nuclear factor-kappa beta(NF-κB)in esophageal mucosa may be related to the injury of epithelial barrier function caused by *** on the literature and our previous study results,it is speculated that inhibition of NF-κB activation may block the insult of GERD on the esophageal mucosal ***-κB may play an important role in the development of *** article reviews the pathogenesis of GERD and the relationship between NF-κB and GERD,in order to provide new strategies for the treatment of GERD.

关键词： Gastroesophageal reflux disease NF-κB Pathogenesis Mechanism Inflammatory injury esophageal epithelial barrier

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