NF-κB: A novel therapeutic pathway for gastroesophageal reflux disease?

作     者：Mao-Lin Zhang Long-Qing Ran Meng-Jun Wu Qin-Chen Jia Zhi-Ming Qin Yong G Peng 

作者机构：Department of Thoracic and Cardiovascular SurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of AnesthesiaChengdu Women's and Children's Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610019China Thoracic and Cardiovascular SurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of AnesthesiologyUniversity of Florida College of MedicineGainesvilleFL 32610United States 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第24期

页      面：8436-8442页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Gastroesophageal reflux disease NF-κB Pathogenesis Mechanism Inflammatory injury Esophageal epithelial barrier 

摘      要：Although gastroesophageal reflux disease(GERD),a common chronic disease in clinical practice,has been widely studied,its potential adverse impact on patients is still a significant clinical *** is necessary to understand the pathogenesis of the disease and choose appropriate treatment according to its *** pathogenesis of GERD is diverse and *** the traditional treatment methods are expensive and ineffective in alleviating symptoms in some patients,new treatment options need to be *** previous study suggested that the activation of nuclear factor-kappa beta(NF-κB)in esophageal mucosa may be related to the injury of epithelial barrier function caused by *** on the literature and our previous study results,it is speculated that inhibition of NF-κB activation may block the insult of GERD on the esophageal mucosal ***-κB may play an important role in the development of *** article reviews the pathogenesis of GERD and the relationship between NF-κB and GERD,in order to provide new strategies for the treatment of GERD.