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Visible fluorescence of biological fluids as a renal failure marker:New integrative approach

Journal of Innovative Optical Health Sciences 2015年第4期8卷 69-84页

作者： Artur I.Kuznetsov Aleksander Frorip Jekaterina Kozlova Vitali Nagirnyi Mai Ots-Rosenberg Ivo Romet Alar Sünter Tartu Science Park AS Ldiamon Riia str.18551014 TartuEstonia Institute of Physics Tartu University Ravila str.14^(c)Tartu 50411Estonia Department of Internal Medicine Tartu University Puusepa str.8Tartu 51014Estonia Biomedicum Tartu University Ravila str.1950411 TartuEstonia

Solid phases of visible fuorescence substance(VFS)of biological fuids(blood,urine,hemodia-lysate)which was proposed earlier as a morbidity and mortality marker by renal failure and diabetes were investigated in-depth by the methods of electron and confocal microscopy,optical spectroscopy and matrix assisted laser desorption-ionization(MALDI)mass *** is shown that dry VFS exists predominantly in the form of carbon-oxygen-nitrogen(N≈8.7 wt.%)nanoparticles(NPs)(5≤d≤100nm).For the first time the existence of the threshold energy E_(g)≈2.15eV for excitation of VFS was observed experimentally and confirmed by semi empirical calculations of the bathochromic shift.A good accordance with the earlier autonomous theo-retical calculations was ***,the long wavelength limit(575 nm)of the spectral range where the VFS can be used as a fluorescent marker was reliably determined.A pilot MALDI comparative study of graphene oxide(GO)and urine VFS was carried *** kinds of nitrogen-free particles(412≤M≤456 Da)were observed in each substance and possible computer models of those have been *** is established that along with nitrogen-containing advanced glycation end products(AGEs)also nitrogen-fee carbon-oxygen-lhydrogen particles(probably toxic)with the composition and structure related to GO can exist in *** types of particles should be taken into account in search for the reasons of high mortality among end stage renal disease patients.

关键词： Auto-fuorescence of biological fuids AGE glycosides end stage renal diseases MALDI of human metabolites fluorescence of graphene oxide

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