检索结果-南通市图书馆

SOME CHARACTERISTICS OF RAT NIGROSTRIATAL DOPAMINERGIC NEUROCONNECTION DURING DEVELOPMENT——A COMBINED IMMUNOCYTOCHEMICAL AND electron-MICROSCOPIC STUDY

引用

Science China Chemistry 1990年第11期33卷 1326-1333页

作者：黄森 Shanghai Brain Research Institute Academia Sinica Shanghai 200031 PRC

The characteristics of the nigrostriatal dopaminergic neuroconnections in developing rats are studied by combined immunocytochemical and electron-microscopic techniques, with an antibody to tyrosine hydroxylase (TH). From the embryonic day 21 on, some of the THpositive nerve fibers are densely packed in the striatum to form a patch-like dopamine island. The percentage of the TH-positive nerve terminals among the labeled profiles is much higher inside than outside the dopamine island (P<0.01). On the other hand, the TH-positive terminals mainly form symmetrical axon-dendritic synapses, while most of the TH-negative terminals form asymmetrical axon-spinous synapses. The functional significance of the characterized dopaminergic connection is discussed.

关键词： nigrostriatal connection dopamine island tyrosine hydroxylase immunocytochemistry electron-microscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Excess iodine supplementation aggravates the toxic effects induced by perchlorate on the male reproductive system in rats

引用

Asian pacific Journal of Reproduction 2021年第5期10卷 215-224页

作者： Arijit Chakraborty Department of Sports&Exercise Science Somaiya Sports AcademySomaiya Vidyavihar UniversityVidyanagarMumbaiMaharashtra 400077India

Objective:To investigate the toxicity of excess iodine and perchlorate co-exposure on male reproductive system in ***:Eighteen male Wistar albino rats were divided into three *** 1 received no treatment and served as the control *** 2 received perchlorate alone(130 mg/kg body weight),and group 3 received perchlorate(130 mg/kg body weight)plus excess iodine(0.7 mg potassium iodine/100 g body weight)for 45 *** perchlorate and iodine excretion pattern,testicular iodine concentration,serum testosterone levels,epididymal sperm count,key enzymes of steroidogenic pathway,reactive oxygen and nitrogen species including total antioxidant profiles in testis with electron microscopic ultrastructure analysis of spermatozoa were ***:Co-exposure of perchlorate and excess iodine reduced their excretion pattern,reflecting accumulation with reactive oxygen species *** was accompanied by higher lipid peroxidation level with imbalance in the pro-/antioxidant status,inhibiting the activities ofΔ^(5)3β-hydroxysteroid dehydrogenase(HSD)and 17β-HSD rate limiting enzyme activities,and causing reduced synthesis of testosterone,parallel to reduction in testicular and accessory sex organs weight,epididymal sperm-count with deformed ultrastructure of *** alone was not a reproductive toxicant;however,in combination with excess-iodine,acute effects were noticed,resulting in a severe deterioration of testicular and spermatozoal structure and ***:This study provides a novel insight on the augmentation of the relatively moderate repro-toxic effects of perchlorate to a more severe form in presence of excess iodine on male reproductive physiology,which justifies further investigations.

关键词： Repro-toxicity Testosterone ROS Spermatozoa Fertility Steroidogenesis electron-microscopy Accessory sex organs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：