SOME CHARACTERISTICS OF RAT NIGROSTRIATAL DOPAMINERGIC NEUROCONNECTION DURING DEVELOPMENT——A COMBINED IMMUNOCYTOCHEMICAL AND ELECTRON-MICROSCOPIC STUDY

作     者：黄森 

作者机构：Shanghai Brain Research Institute Academia Sinica Shanghai 200031 PRC 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：1990年第33卷第11期

页      面：1326-1333页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

主　　题：nigrostriatal connection dopamine island tyrosine hydroxylase immunocytochemistry electron-microscopy 

摘      要：The characteristics of the nigrostriatal dopaminergic neuroconnections in developing rats are studied by combined immunocytochemical and electron-microscopic techniques, with an antibody to tyrosine hydroxylase (TH). From the embryonic day 21 on, some of the THpositive nerve fibers are densely packed in the striatum to form a patch-like dopamine island. The percentage of the TH-positive nerve terminals among the labeled profiles is much higher inside than outside the dopamine island (P0.01). On the other hand, the TH-positive terminals mainly form symmetrical axon-dendritic synapses, while most of the TH-negative terminals form asymmetrical axon-spinous synapses. The functional significance of the characterized dopaminergic connection is discussed.