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Vasculature-on-a-chip with stretchable sensor for recapitulating hemodynamics and electrochemical monitoring of endothelium

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Science China Chemistry 2023年第11期66卷 3314-3322页

作者： Wen-Ting Fan Yi Zhao Feng Hong Yan-Ling Liu Wei-Hua Huang College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China

Vascular endothelium can perceive fluid shear stress(FSS)and cyclic circumferential stretch(CCS)caused by the pulsatile blood flow,and translate the hemodynamics into biochemical signals to regulate vascular ***,existing methods provide little information about the real-time biochemical responses of endothelium when exposed to dynamic FSS and ***,a vasculature-on-a-chip integrated with stretchable sensing is engineered for recapitulating the hemodynamic milieus and in-situ monitoring biochemical responses of endothelial *** integrated device is developed by sandwiching a robust stretchable electrode between an upper fluidic channel and a lower pneumatic *** fluidic and pneumatic channels enable the simultaneous recapitulation of both FSS and CCS,and the integrated sensor exhibits excellent cell-adhesive capacity and electrochemical sensing stability even after long-term hemodynamic *** allow real-time monitoring of hemodynamic form-and duration-dependent endothelium responses,and further efficacy investigation about a recommended drug for COVID-19,demonstrating the great potential in vascular disease and drug screening.

关键词： vasculature-on-a-chip stretchable sensor hemodynamic forces electrochemical monitoring endothelium responses

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Biomimetic Graphene-Based 3D Scaffold for Long-Term Cell Culture and Real-Time electrochemical monitoring

Biomimetic Graphene-Based 3D Scaffold for Long-Term Cell Cul...

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第十届全国化学生物学学术会议

作者： Xue-Bo Hu Yan-Ling Liu Hai-Wei Zhang Wei-Hua Huang Key Laboratory of Analytical Chemistry for Biology and Medicine （Ministry of Education） College of Chemistry and Molecular SciencesWuhan University

It is particularly challenging to construct a multifunctional 3D platform concurrently integrated with the function of cell culture and electrochemical sensing.[1] Herein, we developed a 3-aminophenylboronic acid（APBA） functionalized graphene foam（GF） network, which combines the biomimetic property of APBA with the electrochemical properties of GF. The biomimetic network can serves as a 3D scaffold to culture cells for a long period with high viability（Figure 1a） and simultaneously as an electrode for highly sensitive electrochemical sensing of H2S（Figure 1b）. This allows monitoring of H2S released from the cells cultured on the 3D scaffold in real time. It is anticipated that this platform will open a new route for study towards cellular behaviors under 3D vivo-like microenvironments to reflect in vivo cell functions.

关键词： Graphene foam biomimetic scaffold cell culture electrochemical monitoring

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