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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第1期22卷 52-57页

作者：冀瑞平王新房郑宗锷刘望彭李治安刘俐 The Institute of Cardiology Xiehe Hospital Tongji Medical College Huazhoong University of Science and Technology Wuhan 430030 The First Hospital of Shanxi Medical University Taiyuan 030000 The George Washington University School of Medicine and Health Sciences Washington USA

To evaluate the possibility and accuracy of doppler tissue image (DTI) on assessment of normal and abnormal ventricular activation and contraction sequence, 9 open chest canine hearts were analyzed by acceleration mode, M mode, and spectrum mode DTI. Our results showed that: (1) Acceleration mode DTI could show the origin of activation and conduction sequence on line; (2) M mode DTI revealed that the activation in mid interventricular septum was earlier than that in mid left ventricular posterior wall at sinus activation; (3) Spectrum DTI showed the ventricular endocardium was activated earlier than the ventricular epicardium in all segments at sinus rhythm. The earliest site of activation of the normal ventricular wall was at middle interventricular septum; the latest site was at basal posterior wall; the contraction sequence was different at the different walls; (4) During abnormal ventricular activation, mid left ventricular posterior wall was activated earliest in accordance with the pacing sites. Abnormal ventricular activation was slower than sinus activation, and the contraction sequence varied at different sites of ventricular wall. It is concluded that DTI can be used to localize the origin of normal or abnormal myocardial activation and to assess the contraction sequence conveniently, accurately and non invasively.

关键词： doppler tissue imaging sinus activation abnormal ventricular activation contraction sequence

ASSESSMENT OF DIASTOLIC FUNCTION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY BY doppler tissue imaging

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Chinese Medical Sciences Journal 2004年第3期19卷 203-206页

作者： JingLi Yan-lingLiu HaoWang Xiu-zhangLü Hong-changYang Fu-jianDuan Zhen-huiZhu DepartmentofUltrasound CardiovascularInstituteandFuWaiHospitalChineseAcademyofMedicalSciences＆PekingUnionMedicalCollegeBeijing100037

To determine the clinical application of pulsed doppler tissue imaging in assessing the left ventricular diasto-lic function and in discriminating between normal subjects and patients with hypertrophic cardiomyopathy with various stages of diastolic dysfunction. Methods We measured the peak diastolic velocities of mitral annulus in 81 patients with hypertrophic cardiomyopathy with various stages of diastolic dysfunction and 50 normal volunteers by doppler tissue imaging using the apical window at 2-ch-amber and long apical views, respectively. The myocardial velocities were determined with use of variance F statistical analysis. Results Early diastolic myocardial velocities of mitral annulus were higher in normal subjects than in patients with hy-pertrophic cardiomyopathy with either delayed relaxation, pseudonormal filling, or restrictive filling. However, peak myocar-dial velocities of mitral annulus during atrial contraction were similar in normal subjects and patients with hypertrophic cardiomyopathy. Conclusion doppler tissue imaging can directly reflect upon left diastolic ventricular function. Early phase of diastole was the best discriminator between control subjects and patients with hypertrophic cardiomyopathy.

关键词： doppler tissue imaging left ventricular diastolic function hypertrophic cardiomyopathy

ASSESSMENT OF LEFT VENTRICULAR FUNCTION IN HEALTHY SUBJECTS BY PUSLED WAVE doppler tissue imaging

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Chinese Medical Sciences Journal 2004年第1期19卷 64-67页

作者：李靖刘延玲王浩吕秀章段福建杨洪昌 Department of Ultrasound Cardiovascular Institute and Fu Wai HospitalChinese Academy of Medical Science & Peking Union Medical College

Objective To examine the clinical application of pulsed doppler tissue imaging(DTI)for regional left ventricular function assessment in normal subjects. Methods We examined 50 healthy subjects(range 12-42 years,mean age 28.3 ± 6.9 years)using pulsed doppler tissue imaging to characterize the diastolic and systolic velocity profiles of mitral annulus. Recordings were made along the long axis in the apical 4-chamber, 2-chamber, and long apical views of 6 sites(posterior-septum, lateral, anterior, inferior, anterior-septum, posterior)at the mitral annulus. Myocardial velocities were determined with use of variance F statistical analysis. Correlation analysis was employed to test the relationship between age and mitral annular velocities. Results Both early diastolic and systolic velocities at the septum were lower than other sites. There were no differences in mitral annulus late diastolic velocities. Mean early diastolic and systolic velocities was negatively correlated with age. Conclusions doppler tissue imaging can directly reflect regional left ventricular function.

关键词： doppler tissue imaging left ventricular function

doppler tissue imaging Assessment of Left Ventricular Systolic Dyssynchrony in Severe Heart Failure Patients With a Normal QRS Duration

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South China Journal of Cardiology 2008年第1期9卷 44-48页

作者：陈小珠王洁婷宋素云傅娟张新霞 Department of Ultrasound The Fourth People's Hospital of Shenzhen

Objectives To assess the prevalence of systolic dyssynchrony of the left ventricular （LV） walls in patients of heart failure（HF） with a normal QRS duration by doppler tissue imaging （DTI）. Methods 20 patients of HF with a normal QRS duration and 20 healthy individuals were investigated with DTI to quantitatively analyze their pulsed-wave doppler spectrum of basal and middle segments in six walls of left ventricle. The time between the onset of the QRS complex of the surface ECG and the onset of the systolic wave of pulsed-wave doppler spectrum was measured （TS）. LV systolic synchronization was assessed by the maximal difference （MD） in time of TS, the standard deviation （SD） and the coefficient of variation （CV） of TS in the all 12 LV segments. Results When a TS-MD of TS〉 53.08 ms, a TS-SD of TS 〉18.08 ms and a TS-CV of TS 〉 0.91 （＋1.65 SD of normal controls） was used to define significant systolic dyssynchrony, the prevalence of systolic dyssynchrony was 55.0 %, 55.0 % and 55.0 %, respectively, in the HF patients group, significantly higher than those in the normal control and the locations of delayed contraction of these patients were different. Conclusions LV systolic dyssynchrony could be commonly demonstrated by DTI in HF patients with a normal QRS duration. This finding will support the view about the possibility that more HF patients could benefit from cardiac resynchronization therapy.

关键词： doppler tissue imaging heart failure normal QRS duration systolic dyssynchrony

Value of Low Dose Dobutamine doppler tissue imaging for Detecting Hibernating Myocardium

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Journal of Huazhong University of Science and Technology(Medical Sciences) 1999年第1期19卷 43-46页

作者：杨静胡昭明黎春蕾高淑英

Summary: In order to assess the value of doppler tissue imaging (DTI) in detecting viable hibernating myocardium, 20 patients with coronary artery disease and chronic left ventricular dysfunction underwent low dose dobutamine stress echocardiography and low dose dobutamine stress DTI. The results showed that among the 100 asynergic segments, 35 segments showed improvement after dobutamine infusion (group H) and no changes were observed in the remaining 65 segments (group N). The left ventricular echocardiographic score index decreased from 1.60±0. 35 to 1.44±0.36 ( n =20, P 80 % were viable myocardium. It is concluded that the different reactions to dobutamine stress between hibernating and necrosis myocardium could be showed by DTI and it is more clinically significant when VR≤0 and VR>80 %.

关键词： hibernating myocardium doppler tissue imaging low dose dobutamine stress test

Pig model of chronic myocardial ischemia and its investigation by ultrasonic integrated backscatter and doppler tissue imaging

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Journal of Medical Colleges of PLA(China) 2004年第3期19卷 164-167页

作者：徐静赵宝珍王忠顾俊彦陆世萍 Department of Ultrasound Changhai Hospital Second Military Medical University Department of Anesthesiology Changhai Hospital Second Military Medical University Department of Cardiothoracic surgery Changhai Hospital Second Military Medical University

Objective: To construct an animal model of chronic ischemic myocardium, and evaluate it by ultrasonic integrated backscatter (IBS) and doppler tissue imaging (DTI). Methods: An Ameroid constrictor was placed around the porcine left circumflex coronary artery (LCX). The calibrated average image intensity (%AII), cyclic variation of IBS (CVIB), transmural gradient index (TGI) of CVIB in lateral-posterior wall (LPW), and DTI spectrum of LPW in left ventricular papillary muscle level short axis view (LVPM-SAM) and apical four chamber view (AP-4CV) at normal state, 2, 4, 6 and 8 weeks postoperatively were measured. Results: Normal %AII, CVIB and TGI were 2.29±0.32, 9.69±2.22dB and 0.22±0.08, respectively. The %AII increased gradually postoperatively. The CVIB decreased also gradually, and the decrease was higher in subepicardium than in subendocardium. Most of TGI decrease occurred from 2 to 4 weeks postoperatively and became zero at 8 weeks (P<0.01); Normal V S (peak systolic velocity) of AP-4CV was higher than that of LVPM-SAM (P<0.01). V E (peak early diastolic velocity) of AP-4CV was lower than that of LVPM-SAM (P<0.05). V S and V E were all decreased after operation (P<0.01). The decrease of V S in AP-4CV was greater than that in LVPM-SAM. Conclusion: The pathological changes of the myocardium in human ischemic heart disease (IHD) are similar to that of Ameriod model. IBS and DTI can detect echo changes and ventricular wall motion in chronic ischemic myocardium, and provide more information for clinical investigation and treatment of IHD.

关键词： chronic ischemic myocardium integrated backscatter doppler tissue imaging

tissue doppler Study before and after PCI in Patients with Chronic Stable Angina and Apparent Normal Ventricular Function for Evaluation of Myocardial Function

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World Journal of Cardiovascular Diseases 2020年第7期10卷 395-409页

作者： Hossam Eldin M. Mahmoud Ahmed Boghdady Mohamed A. Alsenbesy Alaa A. Ghalib Ahmed Okasha Huda A. Dardeer Ahlam M. Sabra Internal Medicine Department Qena Faculty of Medicine South Valley University Qena Egypt Cardiology Department Sohag Faculty of Medicine Sohag University Sohag Egypt Internal Medicine Department Sohag Faculty of Medicine Sohag University Sohag Egypt Radiodiagnosis Department Qena Faculty of Medicine South Valley University Qena Egypt

Background: This study aimed to determine the impact of the percutaneous coronary intervention (PCI) on myocardial function assessed by tissue doppler echocardiography. Methods: Conventional two-dimensional echocardiography and Myocardial tissue peak velocities were recorded at the lateral, ***, ***, posterior, ant. and inferior angles of the mitral annulus as well as at the lateral tricuspid annulus by pulsed-wave tissue Doppler echocardiography before PCI, as well as 1 day and 6 weeks after intervention. Results: Fifty consecutive patients with chronic stable angina and preserved systolic left ventricular function (mean age, 58.3 ± 6.594 years;32 men) undergoing PCI were studied. Conventional echocardiographic revealed no statistically significant difference between pre- and post-PCI (1 day after PCI and 6 weeks after PCI) as regarding trans-mitral and trans-tricuspid flow velocities except as regarding LVEDD, LVESD and LVEF which showed a significant improvement post-PCI. Compared with pre-interventional values, systolic peak velocity and early diastolic velocities improved at all sites (P ≤ 0.05 for each). The most pronounced improvement occurred in the septal area. Similarly, late diastol

关键词： doppler tissue imaging Coronary Artery Disease Percutaneous Coronary In-tervention

Evaluation of cardiac function in patients with arrhythmogenic right ventricular cardiomyopathy by echocardiography

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South China Journal of Cardiology 2013年第3期14卷 164-170页

作者：陈春晖吴书林张黔桓费洪文黄俊薛玉梅廖洪涛方咸宏詹贤章 Department of Cardiology Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical Sciences Department of Echocardiology Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical Sciences

Background Arrhythmogenic right ventricular cardiomyopathy （ARVC） mainly performs local myocardial abnormal movements and tissue doppler and spot tracking technique can accurately reflect myocardial movement. However, the technique is still rarely used in research of ARVC. Methods The study enrolled 28 ARVC patients and 28 normal controls. Right ventricular parameters were measured by two-dimensional echocardiography, tissue doppler imaging, speckle tracking imaging in order to compare the difference between two groups. Results Morphological indices （right ventricular inflow tract inner diameter and right ventricular outflow tract inner diameter） and functional indices （right ventricular peak S＇, right ventricular E＇/ A＇ ratio, tricuspid annular plane systolic excursion, right ventricular fractional area change and right ventricular inferior and lateral wall longitudinal strain） showed significant difference between the ARVC group and control group. All the above-mentioned indices were analyzed by receiver operating characteristic curve （ROC curves）. Area under the curve （AUC） of right ventricular inferior wall longitudinal strain was the largest one （AUC = 0.94） with an optimal cutoff value of -19.5%. Conclusion Compared with two- dimensional echocardiography and tissue doppler imaging, right ventricular inferior wall longitudinal strain is a more sensitive predictor for changes of ARVC.

关键词： arrhythmogenic right ventricular cardiomyopathy echocardiography doppler tissue imaging speckle tracking imaging