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direct-acting antiviral agents Resistance-associated Polymorphisms in Chinese Treatment-na（i）ve Patients Infected with Genotype 1b Hepatitis C Virus

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Chinese Medical Journal 2015年第19期128卷 2625-2631页

作者： Ye Wang Hui-Ying Rao Xing-Wang Xie Lai Wei Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory for Hepatitis C and Immunotherapy for Liver DiseaseBeijing 100044China

Background：It has been reported that several baseline polymorphisms of direct-acting antivirals （DAAs） agents resistance-associated variants （RAVs） would affect the treatment outcomes of patients chronically infected with hepatitis C virus （CHC）.The aim of this study is to investigate the prevalence of DAAs RAVs in treatment-na（i）ve GT1b CHC ***：direct sequencing and ultra-deep sequencing of the HCV NS3,NS5A,and NS5B gene were performed in baseline serum samples of treatment-ha（i）ve patients infected with genotype lb hepatitis C virus （HCVs）.Results：One hundred and sixty CHC patients were *** sequence information was obtained for 145 patients （NS3）,148 patients （NS5A）,and 137 patients （NS5B）.Treatment-failure associated variants of DAAs were detected：56.6％（82/145） of the patients presented S122G for simeprevir （NS3 protease inhibitor）;10.1％（14/148） of the patients presented Y93H for daclatasvir and ledipasvir （NS5A protein inhibitors）;94.2％（129/137） of the patients presented C316N for sofosbuvir （NS5B polymerase inhibitor）.Nearly,all of the DAAs RAVs detected by ultra-deep sequencing could be detected by direct ***：The majority of genotype lb CHC patients in China present a virus population carrying HCV DAAs *** sequencing of HCV genome might need to be performed when patients infected with GTlb HCV receiving DAAs-containing regimens in *** sequencing would be quite quantified for the work.

关键词： antiviral Resistance direct antiviral agents Hepatitis C Virus

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Hepatitis C: Problems to extinction and residual hepatic and extrahepatic lesions after sustained virological response

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World Journal of Hepatology 2022年第1期14卷 62-79页

作者： Sara Cuesta-Sancho Mercedes Márquez-Coello Francisco Illanes-Álvarez Denisse Márquez-Ruiz Ana Arizcorreta Fátima Galán-Sánchez Natalia Montiel Manuel Rodriguez-Iglesias José-Antonio Girón-González Medicina Interna Hospital Universitario Puerta del MarFacultad de MedicinaUniversidad de CádizInstituto para la Investigación e Innovación en Ciencias Biomédicas de Cádiz(INiBICA)Cádiz 11009Spain Microbiología Hospital Universitario Puerta del MarFacultad de MedicinaUniversidad de CádizInstituto para la Investigación e Innovación en Ciencias Biomédicas de Cádiz(INiBICA)Cádiz 11009Spain

Loss of follow-up or reinfections hinder the expectations of hepatitis C eradicationdespite the existence of highly effective treatments. Moreover, the elimination ofthe infection does not imply the reversion of those chronic alterations derivedfrom the previous infection by hepatitis C virus (HCV). This review analyzes therisk factors associated with loss to follow-up in diagnosis or treatment, and thepossibility of reinfection. Likewise, it assesses the residual alterations induced bychronic HCV infection considering the liver alterations (inflammation, fibrosis,risk of decompensation, hepatocellular carcinoma, liver transplantation) and, onthe other hand, the comorbidities and extrahepatic manifestations (cryoglobulinemia,non-Hodgkin lymphoma, peripheral insulin resistance, and lipid, boneand cognitive alterations). Peculiarities present in subjects coinfected with humanimmunodeficiency virus are analyzed in each section.

关键词： Hepatitis C virus Sustained virological response direct antiviral agents Human immunodeficiency virus Cirrhosis decompensation Hepatocarcinoma Extrahepatic complications

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antiviral therapy for ＂difficult-to-treat＂ hepatitis C virus-infected patients

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Chinese Medical Journal 2013年第23期126卷 4568-4574页

作者： Tatsuo Kanda Osamu Yokosuka Masao Omata Department of Gastroenterology and Nephrology Chiba UniversityGraduate School of Medicine 1-8-1 Inohana Chuo-ku Chiba Japan Yamanashi Hospitals(Central and Kita)Organization 1-1-1 FujimiKofu-shi Yamanashi Japan University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo Japan

Objective To review the updated research on direct antiviral agents （DAAs）-including regimens for hepatitis C virus （HCV）,and focus on ＂difficult-to-treat＂ HCV-infected *** sources The literature concerning DAAs and hepatitis C cited in this review was collected from PubMed and Google Scholar databases published in English up to July *** selection Data from published articles regarding HCV and DAAs in clinical trials and in clinical use were identified and *** It was recognized that some ＂difficult-to-treat＂ patients would still exist,even though stronger treatments using such as DAAs,including telaprevir and boceprevir,which lead to higher sustained virological response rates,are *** patients include those with advanced fibrosis/cirrhosis,elderly persons,children,HCV-human immunodeficiency virus co-infected patients,HCV-infected recipients,and so *** Certain ＂difficult-to-treat＂ patients would still exist,even though stronger treatment is *** evidence from clinical trials is still lacking,interferon-sparing regimens could have stronger effects for eradicating HCV in such cases.

关键词： advanced cirrhosis direct antiviral agents elderly hepatocellular carcinoma hepatitis C virus interferon-free treatment liver transplant

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Progress and challenges in the comprehensive management of chronic viral hepatitis: Key ways to achieve the elimination

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World Journal of Gastroenterology 2021年第26期27卷 4004-4017页

作者： Fátima Higuera-de la Tijera Alfredo Servín-Caamaño Luis Servín-Abad Department of Gastroenterology and Hepatology Hospital General de MéxicoMexico City 06726Mexico Department of Internal Medicine Hospital General de MéxicoMexico City 06726Mexico Department of Gastroenterology Saint Cloud HospitalSaint CloudMN 56303United States

Chronic viral hepatitis is a significant health problem throughout the world,which already represents high annual *** 2040,chronic viral hepatitis due to virus B and virus C and their complications cirrhosis and hepatocellular carcinoma will be more deadly than malaria,vitellogenesis-inhibiting hormone,and tuberculosis *** this review,we analyze the global impact of chronic viral hepatitis with a focus on the most vulnerable groups,the goals set by the World Health Organization for the year 2030,and the key points to achieve them,such as timely access to antiviral treatment of direct-acting antiviral,which represents the key to achieving hepatitis C virus ***,we review the strategies to prevent transmission and achieve control of hepatitis B ***,we address the impact that the coronavirus disease 2019 pandemic has had on implementing elimination strategies and the advantages of implementing telemedicine programs.

关键词： Hepatitis C Hepatitis B Vaccination Elimination program Telemedicine direct antiviral agents

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Pre-treatment prediction of response to peginterferon plus ribavirin in chronic hepatitis C genotype 3

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World Journal of Hepatology 2015年第4期7卷 703-709页

作者： Sebastian Marciano Silvia M Borzi Melisa Dirchwolf Ezequiel Ridruejo Manuel Mendizabal Fernando Bessone Maria E Sirotinsky Diego H Giunta Julieta Trinks Pablo A Olivera Omar A Galdame Marcelo O Silva Hugo A Fainboim Adrian C Gadano Liver Unit Hospital Italiano de Buenos Aires Hepatology Section Hospital R. Rossi La Plata Buenos Aires Argentina Liver Infectious Disease Unit Hospital F.J Muniz Uspallata 2272 Buenos Aires Argentina Hepatology Section Department of Medicine Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno "CEMIC" Avenida Galvan 4102 Buenos Aires Argentina Hepatology and Liver Transplant Unit Hospital Universitario Austral Hepatology Unit Sanatorio del Parque Rosario Argentina HEPATOSUR group Comodoro Rivadavia Chubut Argentina Internal Medicine Research Unit Hospital Italiano de Buenos Aires Buenos Aires Argentina Basic Science and Experimental Medicine Institute Hospital Italiano de Buenos Aires Internal Medicine Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno "CEMIC" Buenos Aires Argentina

AIM: To evaluate pre-treatment factors associated with sustained virological response(SVR) in patients with hepatitis C virus(HCV) genotype 3 treated with peginterferon and ribavirin(RBV). METHODS: We retrospectively analyzed treatment naive, mono-infected HCV genotype 3 patients treated with peginterferon and RBV. Exclusion criteria included presence of other liver disease, alcohol consumption and African American or Asian ethnicity. The variables collected and compared between patients who achieved an SVR and patients who did not were as follows: gender, age, fibrosis stage, diabetes, body mass index,steatosis, INFL3 polymorphism, pre-treatment HCVRNA, type of peginterferon, RBV dose and adherence. RESULTS: A total of 107 patients treated between June, 2004 and March, 2013 were included. Mean treatment duration was 25.1(± 1.8) wk. Overall, 58%(62/107) of the patients achieved an SVR and 42%(45/107) did not. In the multivariate logistic regression analysis, pre-treatment HCV-RNA ≥ 600000 UI/m L(OR = 0.375, 95%CI: 0.153-0.919, P = 0.032) and advanced fibrosis(OR = 0.278, 95%CI: 0.113-0.684,P = 0.005) were significantly associated with low SVR rates. In patients with pre-treatment HCV-RNA ≥600000 UI/m L and advanced fibrosis, the probability of achieving an SVR was 29%(95%CI: 13.1-45.2).In patients with pre-treatment HCV-RNA direct antiviral agentsbased regimes.

关键词： Sustained virological response direct antiviral agents Sofosbuvir Cirrhosis Viral load

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