Hepatitis C: Problems to extinction and residual hepatic and extrahepatic lesions after sustained virological response

作     者：Sara Cuesta-Sancho Mercedes Márquez-Coello Francisco Illanes-Álvarez Denisse Márquez-Ruiz Ana Arizcorreta Fátima Galán-Sánchez Natalia Montiel Manuel Rodriguez-Iglesias José-Antonio Girón-González 

作者机构：Medicina InternaHospital Universitario Puerta del MarFacultad de MedicinaUniversidad de CádizInstituto para la Investigación e Innovación en Ciencias Biomédicas de Cádiz(INiBICA)Cádiz 11009Spain MicrobiologíaHospital Universitario Puerta del MarFacultad de MedicinaUniversidad de CádizInstituto para la Investigación e Innovación en Ciencias Biomédicas de Cádiz(INiBICA)Cádiz 11009Spain 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第1期

页      面：62-79页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Consejería de Salud,Junta de Andalucía,Integrated Territorial Initiative for the province of Cádiz,No.(ITI)2014-2020 Cofinanced by Fondo Europeo de Desarrollo Regional(FEDER),No.PI-0076-2017 Consejería de Salud,Junta de Andalucía,No.PI 0128/2018 and Instituto de Salud Carlos III,Ministerio de Sanidad,Acción Estratégica en Salud 2017-2020,No.PI19/01361 

主　　题：Hepatitis C virus Sustained virological response Direct antiviral agents Human immunodeficiency virus Cirrhosis decompensation Hepatocarcinoma Extrahepatic complications 

摘      要：Loss of follow-up or reinfections hinder the expectations of hepatitis C eradicationdespite the existence of highly effective treatments. Moreover, the elimination ofthe infection does not imply the reversion of those chronic alterations derivedfrom the previous infection by hepatitis C virus (HCV). This review analyzes therisk factors associated with loss to follow-up in diagnosis or treatment, and thepossibility of reinfection. Likewise, it assesses the residual alterations induced bychronic HCV infection considering the liver alterations (inflammation, fibrosis,risk of decompensation, hepatocellular carcinoma, liver transplantation) and, onthe other hand, the comorbidities and extrahepatic manifestations (cryoglobulinemia,non-Hodgkin lymphoma, peripheral insulin resistance, and lipid, boneand cognitive alterations). Peculiarities present in subjects coinfected with humanimmunodeficiency virus are analyzed in each section.