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Insights into the history and tendency of glycosylation and digestive system tumor:A bibliometric-based visual analysis

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1059-1075页

作者： Jie Jiang Zai Luo Ren-Chao Zhang Yue-Ling Wang Jun Zhang Ming-Yu Duan Zheng-Jun Qiu Chen Huang Department of Gastrointestinal Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Jiangnan University Wuxi School of Medicine Wuxi 214122Jiangsu ProvinceChina Department of Education Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

BACKGROUND Glycosylation,a commonly occurring post-translational modification,is highly expressed in several tumors,specifically in those of the digestive system,and plays a role in various cellular pathophysiological mechanisms.Although the importance and detection methods of glycosylation in digestive system tumors have garnered increasing attention in recent years,bibliometric analysis of this field remains scarce.The present study aims to identify the developmental trends and research hotspots of glycosylation in digestive system tumors.AIM To find and identify the developmental trends and research hotspots of glycosylation in digestive system tumors.METHODS We obtained relevant literature from the Web of Science Core Collection and employed VOSviewer 1.6.19 and CiteSpace(version 6.1.R6)to perform bibliometric analysis.RESULTS A total of 2042 documents spanning from 1978 to the present were analyzed,with the research process divided into three phases:the period of obscurity(1978-1990),continuous development period(1991-2006),and the rapid outbreak period(2007-2023).These documents were authored by researchers from 66 countries or regions,with the United States and China leading in terms of publication output.Reis Celso A had the highest number of publications,while Pinho SS was the most cited author.Co-occurrence analysis revealed the most popular keywords in this field are glycosylation,expression,cancer,colorectal cancer,and pancreatic cancer.Furthermore,the Journal of Proteome Research was the most prolific journal in terms of publications,while the Journal of Biological Chemistry had the most citations.CONCLUSION The bibliometric analysis shows current research focus is primarily on basic research in this field.However,future research should aim to utilize glycosylation as a target for treating tumor patients.

关键词： Glycosylation Cancer digestive system Bibliometric analysis CiteSpace VOS viewer

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Blastomas of the digestive system in adults:A review

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1030-1042页

作者： Yu Liu Tony El Jabbour Jonathan Somma Yukihiro Nakanishi Saverio Ligato Hwajeong Lee Zhi-Yan Fu Department of Pathology LSU Health Sciences Center School of MedicineNew OrleansLA 70112United States Department of Pathology Hartford HealthCareHartfordCT 06102United States Department of Pathology Moffitt Cancer CenterTampaFL 33612United States Department of Pathology and Laboratory Medicine Albany Medical CenterAlbanyNY 12208United States

Blastomas,characterized by a mixture of mesenchymal,epithelial,and undifferentiated blastematous components,are rare malignant neoplasms originating from precursor blast cells.This review focuses on digestive system blastomas in adult patients,including gastroblastoma,hepatoblastoma,and pancreatoblastoma.Gastroblastoma is a biphasic,epitheliomesenchymal tumor,with only sixteen cases reported to date.In addition to the characteristic histology,metastasisassociated lung adenocarcinoma transcript 1-glioma-associated oncogene homolog 1 gene fusion is typical,although recently novel ewing sarcoma breakpoint region 1-c-terminal binding protein 1 and patched 1-glioma-associated oncogene homolog 2 fusions have been described.Hepatoblastoma is exceptionally rare in adults and can show a variety of histologic patterns which may cause diagnostic difficulty.Pancreatoblastoma,primarily a pediatric tumor,displays acinar differentiation and squamoid nests with other lines of differentiation also present,especially neuroendocrine.Diagnostic approaches for these blastomas include a combination of imaging modalities,histopathological examination,and molecular profiling.The treatment generally involves surgical resection,which may be supplemented by chemotherapy or radiotherapy in some cases.Prognoses vary with gastroblastoma generally showing favorable outcomes post-surgery whereas hepatoblastoma and pancreatoblastoma often have poorer outcomes,particularly in the setting of metastases.This review highlights the complexity of diagnosing and managing these rare adult blastomas as well as the need for ongoing research to better understand their pathogenesis and improve treatment strategies.

关键词： Adult blastomas Gastroblastoma Hepatoblastoma Pancreatoblastoma digestive system

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COVID-19 and its effects on the digestive system

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World Journal of Gastroenterology 2021年第24期27卷 3502-3515页

作者： Ting-Ting Cao Gu-Qin Zhang Emily Pellegrini Qiu Zhao Jin Li Lin-jie Luo Hua-Qin Pan Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Respiratory and Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Dascena Inc. HoustonTX 77080United States Department of Gastroenterology The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150Guangdong ProvinceChina Department of Experimental Radiation Oncology and Surgical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Clinical Research Center of Hubei Critical Care Medicine Wuhan 430071Hubei ProvinceChina

Coronavirus disease 2019(COVID-19)is caused by infection of the coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with typical respiratory symptoms.SARS-CoV-2 invades not only the respiratory system,but also other organs expressing the cell surface receptor angiotensin converting enzyme 2.In particular,the digestive system is a susceptible target of SARS-CoV-2.Gastrointestinal symptoms of COVID-19 include anorexia,nausea,vomiting,diarrhea,abdominal pain,and liver damage.Patients with digestive damage have a greater chance of progressing to severe or critical illness,a poorer prognosis,and a higher risk of death.This paper aims to summarize the digestive system symptoms of COVID-19 and discuss fecal-oral contagion of SARS-CoV-2.It also describes the characteristics of inflammatory bowel disease patients with SARSCoV-2 infection and discusses precautions for preventing SARS-CoV-2 infection during gastrointestinal endoscopy procedures.Improved attention to digestive system abnormalities and gastrointestinal symptoms of COVID-19 patients may aid health care providers in the process of clinical diagnosis,treatment,and epidemic prevention and control.

关键词： COVID-19 digestive system Liver function Mechanisms Inflammatory bowel disease Endoscopy

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Clinical study of ultrasound and microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in digestive system

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Chinese Journal of Cancer Research 2018年第5期30卷 553-563页

作者： Yanjie Wang Yan Li Kun Yan Lin Shen Wei Yang Jifang Gong Ke Ding Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Ultrasound Peking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Oncology Peking University Cancer Hospital & Institute

Objective： To explore the safety of ultrasound and microbubbles for enhancing the chemotherapeutic sensitivity of malignant tumors in the digestive system in a clinical trial, as well as its efficacy.Methods： From October 2014 to June 2016, twelve patients volunteered to participate in this study. Eleven patients had hepatic metastases from tumors of the digestive system, and one patient had pancreatic carcinoma. According to the mechanical index （MI） in the ultrasound field, patients were classified into four groups with MIs of 0.4, 0.6, 0.8 and 1.0. Within half an hour after chemotherapy, patients underwent ultrasound scanning with ultrasound microbubbles （SonoVue） to enhance the efficacy of chemotherapy. All adverse reactions were recorded and were classified in 4 grades according to the Common Terminology Criteria for Adverse Events version 4.03 （CTCAE V4.03）. Tumor responses were evaluated by the Response Evaluation Criteria in Solid Tumors version 1.1 criteria. All the patients were followed up until progression.Results： All the adverse reactions recorded were level 1 or level 2. No local pain occurred in any of the patients. Among all the adverse reactions, fever might be related to the treatment with ultrasound combined with microbubbles. Six patients had stable disease （SD）, and one patient had a partial response （PR） after the first cycle of treatment. At the end of follow-up, tumor progression was restricted to the original sites, and no new lesions had appeared.Conclusions： Our preliminary data showed the potential role of a combined treatment with ultrasound and microbubbles in enhancing the chemotherapeutic sensitivity of malignant tumors of the digestive system. This technique is safe when the MI is no greater than 1.0.

关键词： Clinical study sonoporation microbubbles chemotherapy digestive system

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The regulatory roles of aquaporins in the digestive system

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Genes & Diseases 2021年第3期8卷 250-258页

作者： Shengtao Liao Li Gan Lin Lv Zhechuan Mei Department of Gastroenterology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China Teaching and Research Section of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing400016PR China

Aquaporins(AQPs)are highly conserved small transmembrane proteins,which are responsible for the water transport across the cell membrane.AQPs are abundantly expressed in numerous types of cells such as epithelial and endothelial cells.The expression of AQP-1,-3,-4,-5,-8 and-9 were found in the digestive system,where these six AQP isoforms serve essen-tial roles including mediating the transmembrane water transport and regulating the secretion of gastrointestinal(GI)fluids,consequently facilitating the digestion and absorption of GI con-tents.In addition,the expression levels of AQPs are controlled by various factors,and AQPs can stimulate numerous signaling pathways;however,aberrant expression of AQPs in the GI tracts are associated with the initiation and development of numerous diseases.Thus,this re-view provides an overview of the expression and functions of AQPs in the digestive system.

关键词： Aquaporins digestive system Distribution Function Water transfer

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Functions and mechanisms of chemokine receptor 7 in tumors of the digestive system

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World Journal of Clinical Cases 2020年第12期8卷 2448-2463页

作者： Qi Xin Quan Sun Chuan-Shan Zhang Qin Zhang Chun-Jun Li Department of Pathology Tianjin Third Central HospitalThe Third Central Clinical College of Tianjin Medical UniversityTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesTianjin 300170China Tianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational MedicineTianjin UniversityTianjin 300072China Department of Hepatobiliary Surgery Tianjin Third Central HospitalThe Third Central Clinical College of Tianjin Medical UniversityTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesTianjin 300170China Department of Endocrinology Health Management CenterTianjin Union Medical CenterNankai University Affiliated HospitalTianjin 300121China

Chemokine(C-X-C motif)receptor 7(CXCR7),recently termed ACKR3,belongs to the G protein-coupled cell surface receptor family,binds to stromal cellderived factor-1[SDF-1,or chemokine(C-X-C motif)ligand 12]or chemokine(CX-C motif)ligand 11,and is the most common chemokine receptor expressed in a variety of cancer cells.SDF-1 binds to its receptor chemokine(C-X-C motif)receptor 4(CXCR4)and regulates cell proliferation,survival,angiogenesis and migration.In recent years,another new receptor for SDF-1,CXCR7,has been discovered,and CXCR7 has also been found to be expressed in a variety of tumor cells and tumor-related vascular endothelial cells.Many studies have shown that CXCR7 can promote the growth and metastasis of a variety of malignant tumor cells.Unlike CXCR4,CXCR7 exhibits a slight modification in the DRYLAIV motif and does not induce intracellular Ca^2+release following ligand binding,which is essential for recruiting and activating G proteins.CXCR7 is generally thought to work in three ways:(1)Recruitingβ-arrestin 2;(2)Heterodimerizing with CXCR4;and(3)Acting as a“scavenger”of SDF-1,thus lowering the level of SDF-1 to weaken the activity of CXCR4.In the present review,the expression and role of CXCR7,as well as its prognosis in cancers of the digestive system,were investigated.

关键词： Stromal cell-derived factor-1 Chemokine(C-X-C motif)receptor 7 Chemokine(C-X-C motif)receptor 4 Carcinoma digestive system

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Advancements in AI Research for digestive system Diseases

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Journal of Biosciences and Medicines 2023年第12期11卷 173-202页

作者： Qigang Feng Jie Li Xiaoping Tan Qing Zhang Department of Gastroenterology The First People’s Hospital of Yangtze University Jingzhou China digestive Disease Research Institution of Yangtze University Jingzhou China College of Clinical Medical Yangtze University Jingzhou China

With the “boom” of AI, researchers have made significant progress in assisting clinical disease diagnosis, prediction, and treatment. This article provides an overview of models built using both traditional machine learning methods and deep learning methods, as well as research progress on robotics in digestive system diseases, aiming to provide references for further studies. An application has been developed by domestic and foreign scholars that allows users to upload images of stool samples, which are then analyzed using big data to provide a score for bowel preparation, thereby improving the quality of bowel preparation. In some gastrointestinal diseases, such as Hp infection, Barrett’s esophagus and esophageal cancer, chronic atrophic gastritis and gastric cancer, IBD, etc., artificial intelligence possesses diagnostic capabilities comparable to those of professional endoscopists, and some applications can achieve real-time diagnosis. In the field of liver, gallbladder, and pancreatic diseases, artificial intelligence can assist in preoperative diagnosis using imaging or pathology, and robotic remote operations can be performed during surgery, predicting postoperative risk levels, and more. Different scholars have compared and analyzed various algorithm networks for different diseases to find the best-performing models. On this basis, methods such as the MCA attention mechanism, feature selection, gradient descent, and ensemble models can be introduced to further improve the diagnostic performance of the models. In the future, AI can not only help patients self-manage single or multiple diseases, monitor and manage their own diseases in a standardized and reasonable manner, but also predict and treat digestive system diseases at the genetic level.

关键词： AI Deep Learning digestive system Bowel Preparation Medical Imaging Robotics

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A Histomorphological Study on digestive system of Adult Hedgehog

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Journal of Forestry Research 1998年第2期9卷 111-114页

作者：刘二曼王明力王丽萍

Four adult Hedgehogs (Erinaceus euopaeus) (two males and two females) captured from field were used in this test. The samples were quickly taken after killing, and fixed with 10% neutral HCHO. Paraffin sections were done along with HE dying. The results showed that their oesophagus were composed of stratified squamous epithelium, with light monkeiatinized shallow cell and well developed oesophageal glands. There are circular wrinkled wall and intestinal villus on the mucosa of the small intestine with developed small intestinal glands, long and thick intestinal villi in the duodenum, where exists Paneth cell on the basis of intestinal glands. It has isolated lymph nodule in the proper layer of the intestinum jejunum, as well as assemble lymph nodule in the proper layer of mucosa of the ileum. The number of lymph nodule in large intestine increases as compared with others, in which there is longitudinal wrinkled wall, but no intestinal villi. More developed large intestinal glands can be seen, where the cup cell rises gradually from forward to backward along intestinal system. In addition, there is no very clear boundary among liver lobule because the connective tissue among it is not developed well, and so does pancreas.

关键词： Hedgehog Erinaceus euopaeus digestive system Histomorphology

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Structure and Function of the digestive system of Solen Grandis Dunker

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Journal of Ocean University of China 2003年第2期2卷 155-159页

作者： REN Sulian Ocean University of China LMMEC Qingdao 266003 P.R.China Laboratory of Pathology and Immunology of Aquatic Animals

Structure and function of the digestive system of a bivalve mollusc, Solen grandis, were studied using light microscopy and histochemical methods. The wall of digestive tube consists of four layers: the mucosal epithelium, connective tissue, muscular and fibrosa or serosa (only in the portion of rectum) from the inner to the outer. The ciliated columnar epithelial cells, dispersed by cup-shaped mucous cells, rest on a thin base membrane. There are abundant blood spaces in connective tissue layer. The digestive diverticula are composed of multi-branched duct and digestive tubules. The digestive tubules are lined with digestive and basophilic secretory cells, and surrounded by a layer of smooth muscle fibers and connective tissues. Activities of acid and alkaline phosphatases, esterase and lipase are detected in the digestive cells, and the epithelia of stomach and intestine, suggesting that these cells are capable of intracellular digesting of food materials and absorbing. Besides, acid phosphatase and e

关键词： Solen grandis digestive system histology histochemistry

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Azole selenourea disrupted the midgut and caused malformed development of Plutella xylostella

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Journal of Integrative Agriculture 2023年第4期22卷 1104-1116页

作者： GUO Xue-ying HUANG Zi-hao XIONG Lan-tu DONG Li HUANG Yue-kun WEI Lin-hao TANG Ri-yuan WANG Zhi-lin XU Han-hong Department of Applied Chemistry College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642P.R.China Key Laboratory of Natural Pesticide&Chemical Biology of Ministry of Education South China Agricultural UniversityGuangzhou 510642P.R.China

Chemical insecticides targeting the digestive system of diamondback moth(DBM),Plutella xylostella,have not been developed.The discovery of an insecticide with novel mode of action is a challenge for the control of DBM.In this study,a class of selenium-and difluoromethyl-modified azoles(fluoroazole selenoureas,FASU)were designed and synthesized for the control of DBM.Of these azoles,compound B4 showed the highest insecticidal activity against DBM.The LC50of third-and second-instar larvae reached 32.3 and 4.6μg mL^(–1),respectively.The midgut tissue of larvae was severely disrupted,and the larval intestinal tissue was dotted with unique red spots after treatment with compound B4.Compound B4 led to disintegration of the peritrophic matrix,swelling of the midgut epithelium,fracture of the microvilli,and extensive leakage of cellular debris in the midgut lumen.Surviving larvae grew very slowly,and the larval duration was significantly prolonged after exposure to compound B4 at sublethal doses(LC10,LC25and LC50).Furthermore,the pupation rate,emergence rate and pupae weight were significantly decreased.Compound B4 also induced abnormal pupae,causing adults to be trapped in the cocoon or failure to fly due to twisted wings.These results demonstrated that FASU could reduce the population of DBM in sublethal doses.FASU is the first synthetic insecticidal lead compound that has been shown to disrupt the midgut tissue of the larvae of DBM,and its mode of action totally differs from that of commercial chemical insecticides.

关键词： Plutella xylostella azole selenium digestive system midgut

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