Functions and mechanisms of chemokine receptor 7 in tumors of the digestive system

作     者：Qi Xin Quan Sun Chuan-Shan Zhang Qin Zhang Chun-Jun Li 

作者机构：Department of PathologyTianjin Third Central HospitalThe Third Central Clinical College of Tianjin Medical UniversityTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesTianjin 300170China Tianjin Key Laboratory of Brain Science and Neural EngineeringAcademy of Medical Engineering and Translational MedicineTianjin UniversityTianjin 300072China Department of Hepatobiliary SurgeryTianjin Third Central HospitalThe Third Central Clinical College of Tianjin Medical UniversityTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesTianjin 300170China Department of EndocrinologyHealth Management CenterTianjin Union Medical CenterNankai University Affiliated HospitalTianjin 300121China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第12期

页      面：2448-2463页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Key Projects of Tianjin Natural Science Foundation,No.19JCZDJC36100 General Project of Natural Science Fund of Tianjin Education Commission,No.2018KJ047 Subject in the Third Affiliated Central Hospital of Nankai University,No.2017YNY3 Tianjin Key Special Projects,No.15KG115 

主　　题：Stromal cell-derived factor-1 Chemokine(C-X-C motif)receptor 7 Chemokine(C-X-C motif)receptor 4 Carcinoma Digestive system 

摘      要：Chemokine(C-X-C motif)receptor 7(CXCR7),recently termed ACKR3,belongs to the G protein-coupled cell surface receptor family,binds to stromal cellderived factor-1[SDF-1,or chemokine(C-X-C motif)ligand 12]or chemokine(CX-C motif)ligand 11,and is the most common chemokine receptor expressed in a variety of cancer ***-1 binds to its receptor chemokine(C-X-C motif)receptor 4(CXCR4)and regulates cell proliferation,survival,angiogenesis and *** recent years,another new receptor for SDF-1,CXCR7,has been discovered,and CXCR7 has also been found to be expressed in a variety of tumor cells and tumor-related vascular endothelial *** studies have shown that CXCR7 can promote the growth and metastasis of a variety of malignant tumor *** CXCR4,CXCR7 exhibits a slight modification in the DRYLAIV motif and does not induce intracellular Ca^2+release following ligand binding,which is essential for recruiting and activating G ***7 is generally thought to work in three ways:(1)Recruitingβ-arrestin 2;(2)Heterodimerizing with CXCR4;and(3)Acting as a“scavengerof SDF-1,thus lowering the level of SDF-1 to weaken the activity of *** the present review,the expression and role of CXCR7,as well as its prognosis in cancers of the digestive system,were investigated.