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Correlation between the gut microbiome and neurodegenerative diseases:a review of metagenomics evidence

Neural Regeneration Research 2024年第4期19卷 833-845页

作者： Xiaoyan Liu Yi Liu Junlin Liu Hantao Zhang Chaofan Shan Yinglu Guo Xun Gong Mengmeng Cui Xiubin Li Min Tang School of Life Sciences Jiangsu University Institute of Animal Husbandry Jiangsu Academy of Agricultural Sciences Department of Rheumatology&Immunology Affiliated Hospital of Jiangsu University Department of Neurology The Second Affiliated Hospital of Shandong First Medical University

A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain *** a contributing factor,microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral ***-throughput sequencing technology has helped to reveal that the bidirectional communication between the central nervous system and the enteric nervous system is facilitated by the microbiota’s diverse microorganisms,and for both neuroimmune and neuroendocrine ***,we summarize the bioinformatics analysis and wet-biology validation for the gut metagenomics in neurodegenerative diseases,with an emphasis on multi-omics studies and the gut *** pathogen-associated signaling biomarkers for identifying brain disorders and potential therapeutic targets are also ***,we discuss the role of diet,prebiotics,probiotics,postbiotics and exercise interventions in remodeling the microbiome and reducing the symptoms of neurodegenerative diseases.

关键词： biomarker diet pattern gut microbiota gut-brain axis metagenomics mitochondrial dysfunction multi-omics neurodegenerative disease neuroinflammation probiotic

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Assessment of dietary Habits and Nutritional Status of Women of Childbearing Age in Cameroon: A Cross Sectional Study

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Open Journal of Epidemiology 2020年第4期10卷 369-392页

作者： Christelle Momdjo M’bobda Judith Laure Ngondi Françoise Raïssa Ntentie Boris Ronald Tonou Tchuente Maxwell Wandji Nguedjo Boris Gabin Kingue Azantsa Julius Enyong Oben Laboratory of Nutrition and Nutritional Biochemistry Department of Biochemistry Faculty of Science University of Yaoundé I Yaounde Cameroon Higher Teacher’s and Training College University of Maroua Maroua Cameroon Centre for Food and Nutrition Research IMPM Ministry of Scientific Research and Innovation Yaounde Cameroon

Background: Malnutrition due to poor feeding habits, is still a serious public health issue in Cameroon. The objective of this study was to assess the dietary patterns and nutritional status of women of childbearing age in various geographical settings in Cameroon so as to propose intervention strategies. Methods: In a cross sectional study conducted from January 2014 to August 2015, women aged 14 - 49 years were randomly selected from the capital city Yaounde and four regions of Cameroon. Anthropometric measures were collected for nutritional status assessment. Data on diet habits and socio-demographic parameters were collected. Results: 608 women of reproductive age with average age 34.68 ± 0.39 years made up the study. dietary patterns assessment revealed that, most study participants had a frequent intake of carbohydrate rich foods and fats and oils rich foods;but an infrequent intake of protein rich foods and vitamin and minerals rich foods in a week. Nutritional status assessment revealed that, 2.1% were underweight, 28.6% had a normal weight, 30.8% overweight, and 38.5% obese. The grass field regions presented the highest prevalence of underweight, overweight and obesity. Higher malnutrition levels were linked to low intakes of pulses and beans;milk and dairy products;vegetables and fruits food groups. Conclusion: Women of the study population had an unhealthy dietary pattern and a poor nutritional status. Therefore, strategies such as nutritional education are warranted and should be age and region specific, so as to target specific groups of women and ensure adequate nutritional status and health.

关键词： diet pattern Nutritional Status Childbearing Age Women Cameroon

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2型糖尿病患者肠道菌群结构变化与代谢标志物和膳食模式的关系

2型糖尿病患者肠道菌群结构变化与代谢标志物和膳食模式的关系

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中国营养学会第十五届全国营养科学大会

作者：李琳琳李玉倩王重建毛振兴郑州大学公共卫生学院郑州大学药学院

目的 To explore correlation with intestinal microbiota and dietary intake pattern in Chinese type 2 diabetes mellitus (T2DM) patients.方法 The case-control study included 74 T2DM patients and 76 controls. Principal component analysis was used to determine dietary patterns and correlation analysis was used to evaluate the associations between microbiota diversity, T2DM indicators and dietary patterns.结果 Compared to controls, the T2DM group had lower alpha diversity, higher Firmicutes/Bacteroidetes ratios, significant beta diversity. Gut microbiota was associated with HOMA2-β, fasting plasma glucose, HbA1c and fasting insulin. The animal foods pattern scores were positively correlated with the relative abundance of the phylum Fusobacteria, and the vegetarian diet pattern scores were positively correlated with the relative abundance of the phylum Actinobacteria (all P <0.05).结论 The gut microbiota may play an important role in the etiology of T2DM.

关键词： T2DM Gut microbiota Metabolic markers diet pattern

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