2型糖尿病患者肠道菌群结构变化与代谢标志物和膳食模式的关系
作者单位：郑州大学公共卫生学院 郑州大学药学院
会议名称：《中国营养学会第十五届全国营养科学大会》
会议日期：2022年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100403[医学-营养与食品卫生学] 10[医学]
关 键 词：T2DM Gut microbiota Metabolic markers Diet pattern
摘 要：目的 To explore correlation with intestinal microbiota and dietary intake pattern in Chinese type 2 diabetes mellitus (T2DM) patients.方法 The case-control study included 74 T2DM patients and 76 controls. Principal component analysis was used to determine dietary patterns and correlation analysis was used to evaluate the associations between microbiota diversity, T2DM indicators and dietary patterns.结果 Compared to controls, the T2DM group had lower alpha diversity, higher Firmicutes/Bacteroidetes ratios, significant beta diversity. Gut microbiota was associated with HOMA2-β, fasting plasma glucose, HbA1c and fasting insulin. The animal foods pattern scores were positively correlated with the relative abundance of the phylum Fusobacteria, and the vegetarian diet pattern scores were positively correlated with the relative abundance of the phylum Actinobacteria (all P 0.05).结论 The gut microbiota may play an important role in the etiology of T2DM.