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Clinical efficacy of femtosecond laser-assisted phacoemulsification in diabetic cataract patients

World Journal of Clinical Cases 2024年第10期12卷 1733-1741页

作者： Yi-Fei Tang Zhi-Hui Duan Department of Glaucoma and cataracts Han Yang Eyegood Ophthalmic HospitalWuhan 430056Hubei ProvinceChina

BACKGROUND diabetic patients with cataracts encounter specific difficulties during cataract surgery due to alterations in microcirculation,blood supply,metabolism,and the *** phacoemulsification may not fully tackle these issues,especially in instances with substantial preoperative *** utilization of femtosecond laser-assisted phacoemulsification,in conjunction with Toric intraocular lens(IOL)implantation,offers a potentially more efficient *** research seeks to evaluate the efficacy and possible complications of this approach in diabetic cataract *** To investigate the clinical efficacy and complications of femtosecond laser-assisted phacoemulsification combined with Toric IOL implantation in diabetic cataract patients,comparing it with traditional phacoemulsification *** This retrospective study enrolled 120 patients with diabetes cataract from May 2019 to May *** patients were divided into two groups:the control group underwent traditional phacoemulsification and Toric IOL implantation,while the treatment group received Len Sx femtosecond laser-assisted *** measures included naked eye vision,astigmatism,high-level ocular phase difference detection,clinical efficacy,and *** There were no significant preoperative differences in astigmatism or naked eyesight between the two ***,postoperative improvements were observed in both groups,with the treatment group showing greater enhancements in naked eye vision and astigmatism six months after the ***-level corneal phase difference tests also indicated significant differences in favor of the treatment *** This study suggests that femtosecond laser-assisted phacoemulsification combined with Toric IOL implantation appears to be more effective in enhancing postoperative vision in diabetic cataract patients compared to traditional methods offering valuable insights for clinical practice.

关键词： diabetic cataract Femtosecond laser-assisted phacoemulsification Toric intraocular lens implantation Naked vision

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Analysis of N6-methyladenosine-modified mRNAs in diabetic cataract

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World Journal of Diabetes 2023年第7期14卷 1077-1090页

作者： Lei Cai Xiao-Yan Han Dan Li Dong-Mei Ma Yu-Meng Shi Yi Lu Jin Yang Department of Ophthalmology EyeEarNoseand Throat Hospital of Fudan UniversityShanghai 200031China Key Laboratory of Myopia Ministry of HealthShanghai 200031China Shanghai Key Laboratory of Visual Impairment and Restoration Shanghai Key Laboratory of Visual Impairment and RestorationShanghai 200031China Visual Rehabilitation Professional Committee Chinese Association of Rehabilitation MedicineShanghai 200031China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200031China

BACKGROUND cataracts remain a prime reason for visual disturbance and blindness all over the world,despite the capacity for successful surgical replacement with artificial *** cataract(DC),a metabolic complication,usually occurs at an earlier age and progresses faster than age-related *** has linked N6-methyladenosine(m6A)to DC ***,there exists a lack of understanding regarding RNA m6A modifications and the role of m6A in DC *** To elucidate the role played by altered m6A and differentially expressed mRNAs(DEmRNAs)in *** Anterior lens capsules were collected from the control subjects and patients with DC.M6A epitranscriptomic microarray was performed to investigate the altered m6A modifications and determine the *** Gene Ontology and pathway enrichment(Kyoto Encyclopedia of Genes and Genomes)analyses,the potential role played by dysregulated m6A modification was ***-time polymerase chain reaction was further carried out to identify the dysregulated expression of RNA methyltransferases,demethylases,and *** Increased m6A abundance levels were found in the total mRNA of DC *** analysis predicted that ferroptosis pathways could be associated with m6A-modified *** levels of five methylation-related genes-RBM15,WTAP,ALKBH5,FTO,and YTHDF1-were upregulated in DC *** of RBM15 expression was verified in SRA01/04 cells with high-glucose medium and in samples from DC *** M6a mRNA modifications may be involved in DC progression via the ferroptosis pathway,rendering novel insights into therapeutic strategies for DC.

关键词： N6-methyladenosine diabetic cataract RNA Ferroptosis Epitranscriptomic microarray

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Effects of Dendrobium candidum polysaccharides on microRNA-125b and mitogen-activated protein kinase signaling pathways in diabetic cataract rats

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Traditional Medicine Research 2021年第5期6卷 43-48页

作者： Zi-Yang Chen Qian Lan Sheng Chen Yan-Hong Hu Fa-Jie Ke Jun Hu Chun-Yan Feng Ming-Xin Qi Xiu-Rong Huang Comprehensive Clinic of Fujian Academy of Chinese Medicine Fuzhou 350003China Fujian University of Traditional Chinese Medicine Fuzhou 350122China Department of Opthalmology The Second Affiliated Hospital of Fujian Traditional Chinese Medical UniversityFuzhou 350003China

Background:diabetic cataract is a common complication and a lens disorder in ***,Dendrobium officinale polysaccharide(DOP)is found to alleviate diabetes ***,microRNA-125b and mitogen-activated protein kinase signaling pathways play significant roles in ***,the mechanism and the effect of DOP on diabetic cataract remains ***:Wistar male rats were randomly assigned to the control,model,and DOP *** was induced with ***,DOP was orally given for 12 *** Lens Opacities Classification System III was used to evaluate lens opacity by slit-lamp *** lens was then harvested for testing the mRNA expression of microRNA-125b,ERK1,ERK2,Raf and Ras using reverse transcription-polymerase chain *** protein expression of ERK1,ERK2,Raf,and Ras was detected using the Western blot *** targets of microRNA-125b were predicted in miRWalk *** targets were obtained from the Kyoto Encyclopedia of Genes and Genomes ***:The lens opacities of the rats in the control group were almost at ***,the majority of the lens opacities in the model group were C3 to C4 and N1 to N2,and were mostly at C1 to C2 and N0 to N1 in the DOP *** difference was statistically significant(P<0.05).Furthermore,the microRNA-125b expression in the model group is significantly higher compared with the control ***,the microRNA-125b expression in the DOP group is significantly decreased(all P<0.05).The mRNA expression of ERK1,ERK2,Raf,and Ras in the model groups were upregulated compared with those of the control ***,the ERK1 and Raf mRNA expressions of the DOP group were lower compared with the model group(all P<0.05).The protein expression of ERK1,Raf,and Ras in the model group was significantly increased compared with those of the control *** protein expression of ERK1,Raf,and Ras in the DOP group was significantly lower compared with

关键词： Dendrobium officinale polysaccharide microRNA-125b mitogen-activated protein kinase diabetic cataract

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Oxidative stress,epigenetic regulation and pathological processes of lens epithelial cells underlying diabetic cataract

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Advances in Ophthalmology Practice and Research 2023年第4期3卷 180-186页

作者： Zaoxia Guo Xiaopan Ma Rui Xue Zhang Hong Yan Shaanxi Eye Hospital Xi'an People's Hospital(Xi'an Fourth Hospital)Affiliated People's Hospital of Northwest UniversityXi'anShaanxiChina Xi'an Key Laboratory of Stem Cell and Regenerative Medicine Institute of Medical ResearchNorthwestern Polytechnical UniversityXi'anShaanxiChina

Background:cataract is a blinding disease *** is an age-related disease that mainly occurs in people over 65 years *** is also prevalent in patients with diabetes mellites(DM).The pathological mechanisms underlying diabetic cataract(DC)are more complex than that of age-related *** have identified that polyol pathway,advanced glycation end products(AGEs)and oxidative stress are the primary pathogenesis of *** recent years,molecular-level regulations and pathological processes of lens epithelial cells(LECs)have been confirmed to play roles in the initiation and progression of DC.A comprehensive understanding and elucidation of how chronic hyperglycemia drives molecular-level regulations and cytopathological processes in the lens will shed lights on the prevention,delay and treatment of *** text:Excessive glucose in the lens enhances polyol pathway and AGEs *** pathway causes imbalance in the ratio of NADPH/NADPt and NADH/*** in NADPH/NADPt ratio compromises antioxidant enzymes,while increase in NADH/NADt ratio promotes reactive oxygen species(ROS)overproduction in mitochondria,resulting in oxidative *** stress in the lens causes oxidation of DNA,proteins and lipids,leading to abnormalities in their structure and *** of proteins by AGEs decreases solubility of *** glucose triggered epigenetic regulations directly or indirectly affect expressions of genes and proteins in *** in autophagic activity,increases in fibrosis and apoptosis of LECs destroy the morphological structure and physiological functions of the lens epithelium,disrupting lens ***:In both diabetic animal models and diabetics,oxidative stress plays crucial roles in the formation of *** regulations,include lncRNA,circRNA,microRNA,methylation of RNA and DNA,histone acetylation and pathological processes,include autophagy,fibrosis and apoptosis of LECs also involved i

关键词： Oxidative stress Epigenetic regulation Autophagy Fibrosis Apoptosis diabetic cataract

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Expression and regulation of microRNA-29a and microRNA-29c in early diabetic rat cataract formation

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1719-1724页

作者： Ying Sun Chun-Mei Lu Zhen Song Ke-Ke Xu Shu-Bin Wu Zhi-jian Li Department of Ophthalmology First Affiliated HospitalHarbin Medical University Harbin 150001 Heilongjiang Province China Department of Ophthalmology Second Hospital of Heilongjiang Province Harbin 150001 Heilongjiang Province China Department of Physiology Harbin Medical UniversityHarbin 150001 Heilongjiang Province China

AIM： To determine the role of microRNA （miRNA）-29a and miRNA-29c in the regulation of apoptosis in early rat diabetic cataract ***： Streptozotocin （STZ）-induced diabetic Sprague-Dawley （SD） rats were used in the study. The expression level of miRNA-29a, miRNA-29c, and BCL2-modifying factor （BMF） in lens epithelial cells （LECs） samples were measured using quantitative real-time polymerase chain reaction. Prediction algorithms of miRanda, TargetScan 6.2, and mirRDB to perform a miRNA gene network analysis were used for the potential miRNA-29a and miRNA-29c targets. RESULTS： The miRNA-29a and miRNA-29c expression levels were all significantly lower in the control group compared to the 2 and 4wk diabetic samples （P〈0.01）. The network analysis indicated that one miRNA-29a and miRNA-29c targets was BMF. There was significantly higher expression of BMF mRNA compared to the normal controls （P〈0.01）. CONCLUSION： Apoptosis occurs in rat LECs following high blood glucose exposure. It is likely that apoptosis during diabetic cataract formation involves the decreased expression of miRNA-29a and miRNA-29c and the increased expression of BMF.

关键词： microRNA-29a microRNA-29c BCL2-modifying factor apoptosis diabetic cataract

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The Prevention and Treatment of Polysaccharide from the Rhizomorph of Armillaria mellea on diabetic cataract in Rat

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Agricultural Science & Technology 2014年第7期15卷 1086-1088页

作者：许宝奎张烨安徽大学江淮学院安徽合肥230039

[Objective] To investigate the prevention and control effect of polysaccharide from the rhizomorph of Armillaria mellea by distilled water elution （AMP-1） on diabetic cataract in rats.[Methods] Streptozotocin （STZ）,combined with freund＇s adjuvant （CFA）,was used to induce diabetic cataract in rat,to observe the onset of lenticular turbidity by slit lamp and compare the turbid degree of eyes lens among different *** super oxide dismutase （SOD）,glutathione peroxidase （GSH-px） and malondialdehyde （MDA） in serum and eyes lens were measured by colorimetric method.[Results] The slit lamp examination results showed that AMP-1 obviously delayed the onset of diabetic cataract and reduced turbid degree of eyes *** with model group,AMP-1 at various doses should significantly reduce the level of MDA ascended in serum of ***-and high-dose groups could increase the levels of SOD and GSH-Px in serum,and the dose of AMP-1 was closely related to the effect.[Conclusion] AMP-1 played a prominent role in prevention and treatment of diabetic cataract in rats.

关键词： Polysaccharide from the rhizomorph of Armillaria mella(AMP) STZ Freund's adjuvant(CFA) diabetic cataract

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Astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1186-1195页

作者： Na Wang Deepika Singh Qiong Wu Department of Ophthalmology Shaanxi Eye HospitalXi’an People’s Hospital(Xi’an Fourth Hospital)Affiliated People’s Hospital of Northwest UniversityXi’an 710004Shaanxi ProvinceChina Department of Pharmaceutical Sciences Sam Higginbottom University of AgricultureTechnology and SciencesPrayagraj 211007India

AIM:To investigate the aldose reductase(AR)inhibition capacity of astragalin(AST)against streptozoticin-induced diabetic cataracts(DCs)in ***:Ex vivo investigations were conducted by treating the lens of a goat placed for 72h in artificial aqueous humor(AAH)of pH 7.8 at room temperature with cataract-causing substance(55 mmol/L of galactose)and in vivo studies were performed on rats via induction with *** was administered at different dose levels and scrutinize for DC ***:In diabetic rats,AST improved the body weight,blood insulin,and glucose as well as the levels of galactitol in a dose-dependent way,other biochemical parameters *** mediators and cytokines,and also suppress AR *** level of the antioxidant parameters such as superoxide dismutase(SOD),catalase(CAT),and glutathione(GSH)activity were also altered on a diabetic lens after the administration of the ***:AST protects against lens opacification to avoid cataracts and polyols formation,indicating that it could be used as a potential therapeutic agent for diabetes.

关键词： astragalin diabetic cataract lens opacification aldose reductase rats

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Advances in the Pathogenesis and Pharmacologic Treatment of diabetic cataracts

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Journal of Clinical and Nursing Research 2024年第7期8卷 173-177页

作者： Xin Kou Department of Surgery Ocean University of China HospitalQingdao 266100Shandong ProvinceChina

diabetic cataract(DC)is a common complication prior to diabetes mellitus,which is a metabolic disease with pathogenesis including abnormal metabolism of polyphenol pathway(PP)and non-enzymatic glycosylation(NEG)of proteins,*** therapeutic drugs are mainly aldose reductase inhibitors(ARIs)and glycosylation *** therapeutic regimens for DC are becoming more and more diversified due to the development of biological testing and clinical research technology,thus improving its clinical *** the development of biological testing and clinical research technology,the treatment options for DC have become increasingly diversified and the treatment specificity has been improved,improving its clinical *** order to comprehensively analyze the pathogenesis and pharmacological treatment of this disease,the following review is made.

关键词： diabetic cataract Pathogenesis Drug therapy

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Repression of Polyol Pathway Activity by Hemidesmus indicus *** *** Root Extract,an Aldose Reductase Inhibitor:An In Silico and Ex Vivo Study

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Natural Products and Bioprospecting 2021年第3期11卷 315-324页

作者： Hajira Banu Haroon Vijaybhanu Perumalsamy Gouri Nair Dhanusha Koppal Anand Rajitha Kolli Joel Monichen Kanchan Prabha Department of Pharmacology Faculty of PharmacyM S Ramaiah University of Applied SciencesGnanagangothri CampusNew BEL RoadBengaluruKarnataka 560054India Department of Pharmaceutical Chemistry Faculty of PharmacyM S Ramaiah University of Applied SciencesGnanagangothri CampusNew BEL RoadBengaluruKarnataka 560054India Department of Pharmaceutics Faculty of PharmacyM S Ramaiah University of Applied SciencesGnanagangothri CampusNew BEL RoadBengaluruKarnataka 560054India

Development of diabetic cataract is mainly associated with the accumulation of sorbitol via the polyol pathway through the action of Aldose reductase(AR).Hence,AR inhibitors are considered as potential agents in the management of diabetic *** study explored the AR inhibition potential of Hemidesmus indicus *** root extract by in silico and ex vivo *** docking studies(Auto Dock tool)betweenβ-sitosterol,hemidesminine,hemidesmin-1,hemidesmin-2,and AR showed thatβ-sitosterol(−10.2 kcal/mol)and hemidesmin-2(−8.07 kcal/mol)had the strongest affinity to AR *** vivo studies were performed by incubating isolated goat lenses in artificial aqueous humor using galactose(55 mM)as cataract inducing agent at room temperature(pH 7.8)for 72 *** treatment with Vitamin E acetate−100μg/mL(standard)and test extract(500 and 1000μg/mL)separately,the estimation of biochemical markers showed inhibition of lens AR activity and decreased sorbitol ***,extract also normalized the levels of antioxidant markers like SOD,CAT,*** results showed evidence that *** *** root was able to prevent cataract by prevention of opacification and formation of polyols that underlines its potential as a possible therapeutic agent against diabetic complications.

关键词： Hemidesmus indicus var.pubescens Aldose reductase Polyol pathway diabetic cataract

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