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Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway

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Journal of Traditional Chinese Medicine 2023年第5期43卷 906-914页

作者： LIU Bingbing LI Jieru SI Jianchao CHEN Qi YANG Shengchang JI Ensheng Department of Physiology Hebei University of Chinese MedicineShijiazhuang 050200China Hebei Technology Innovation Center of TCM Combined Hydrogen Medicine Shijiazhuang 050200China

OBJECTIVE:To examine the protective effect of ginsenoside Rb1(Rb1),the main component of Renshen(Radix Ginseng),on cardiomyopathy in db/db mice exposed to chronic intermittent hypoxia(CIH)and explore the potential underlying mechanism of Rb1 in treating diabetic cardiomyopathy(DCM).METHODS:The db/db mice were randomly separated into five groups:normal control group,model group,Rb120 mg/kg group,Rb140 mg/kg group,and glucagon-like peptide-1(GLP-1)*** were exposed to aircondition or CIH for 8 weeks,and Rb1 and GLP-1 were administrated before CIH exposure every *** glucose tolerance test(OGTT),intraperitoneal insulin tolerance test(IPITT),total cholesterol(TC),triglyceride(TG),and high-density lipoprotein cholesterol(HDL-C)were detected to evaluate glycolipid *** level of insulin was detected by a mouse enzyme-linked immunosorbent assay(ELISA).Cardiac function was detected by echocardiography,and myocardial pathology was observed by hematoxylin-eosin and Masson *** expression of collagenⅠand collagenⅢwas detected by *** monophosphate-activated protein kinase(AMPK)/Nrf2/heme oxygenase-1(HO-1)signaling pathway was detected by Western blot and ***:Rb1 treatment could improve glucose tolerance and the level of cardiac function indexes,and inhibit the level of oxidative stress indexes and the expression of collagenⅠand collagenⅢ.Moreover,Rb1 treatment enhanced AMPK phosphorylation and increased Nrf2 and HO-1 ***:Rb1 treatment alleviated CIH-induced diabetic cardiomyopathy and glycolipid metabolism disorders in db/db mice by inhibiting oxidative stress and regulating the AMPK/Nrf2/HO-1 signaling pathway.

关键词： ginsenosides diabetic cardiomyopathies oxidative stress AMP-activated protein kinases heme oxygenase-1 signal transduction chronic intermittent hypoxia

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Mitochondrial energy metabolism in diabetic cardiomyopathy:Physiological adaption,pathogenesis,and therapeutic targets

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Chinese Medical Journal 2024年第8期137卷 936-948页

作者： Wanlin Ye Kun Han Maodi Xie Sheyu Li Guo Chen Yanyan Wang Tao Li Department of Anesthesiology Laboratory of Mitochondria and MetabolismNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Anesthesiology West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan UniversityMinistry of EducationChengduSichuan 610041China Department of Endocrinology and Metabolism Division of Guideline and Rapid RecommendationCochrane China CenterMAGIC China CenterChinese Evidence-Based Medicine CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Nursing Key Laboratory of Sichuan Province West China HospitalSichuan UniversityChengduSichuan 610041China

diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes,which could eventually develop heart failure and leads to the death of the *** blood glucose control and medications to heart failure show beneficial effects on this disease,there is currently no specific treatment for diabetic *** the past few decades,the pathophysiology of diabetic cardiomyopathy has been extensively studied,and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic *** this review,we summarize the latest research in the field of diabetic cardiomyopathy,focusing on mitochondrial damage and adaptation,altered energy substrates,and potential therapeutic targets.A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.

关键词： Mitochondria Mitochondrial energy metabolism diabetic cardiomyopathies Physiology Physiological adaption Pathogenesis Therapeutics

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