Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway

作     者：LIU Bingbing LI Jieru SI Jianchao CHEN Qi YANG Shengchang JI Ensheng LIU Bingbing;LI Jieru;SI Jianchao;CHEN Qi;YANG Shengchang;JI Ensheng

作者机构：Department of PhysiologyHebei University of Chinese MedicineShijiazhuang 050200China Hebei Technology Innovation Center of TCM Combined Hydrogen MedicineShijiazhuang 050200China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2023年第43卷第5期

页      面：906-914页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Natural Science Foundation of Hebei Province:the Central Regulatory Mechanism of Tanshinone IIA on AngiotensinⅡInduced Sympathetic Excitation in Intermittent Hypoxia(No.H2019423136) Fundamental Research Funds for the Provisional Universities of Hebei University of Chinese Medicine:a Study on the Protective Mechanism of Hydrogen on Chronic Intermittent Hypoxiainduced Microglia Inflammatory Response(No.YTZ2019001) a Study on the Molecular Mechanism of Improving Effect Danggui Buxue Decoction on Vascular Endothelial Cell Senescence in Chronic Intermittent Hypoxia through Nrf2/HO-1 Signaling Pathway(No.YXTD2021005) Graduate Innovation Fund of Hebei University of Chinese Medicine:the Effect of Jinlida Granules on the Myocardial Improvement of Chronic Intermittent Hypoxia Aggravated Diabetic Cardiomyopathy in db/db Mice(No.XCXZZBS2022013) 

主　　题：ginsenosides diabetic cardiomyopathies oxidative stress AMP-activated protein kinases heme oxygenase-1 signal transduction chronic intermittent hypoxia 

摘      要：OBJECTIVE:To examine the protective effect of ginsenoside Rb1(Rb1),the main component of Renshen(Radix Ginseng),on cardiomyopathy in db/db mice exposed to chronic intermittent hypoxia(CIH)and explore the potential underlying mechanism of Rb1 in treating diabetic cardiomyopathy(DCM).METHODS:The db/db mice were randomly separated into five groups:normal control group,model group,Rb120 mg/kg group,Rb140 mg/kg group,and glucagon-like peptide-1(GLP-1)*** were exposed to aircondition or CIH for 8 weeks,and Rb1 and GLP-1 were administrated before CIH exposure every *** glucose tolerance test(OGTT),intraperitoneal insulin tolerance test(IPITT),total cholesterol(TC),triglyceride(TG),and high-density lipoprotein cholesterol(HDL-C)were detected to evaluate glycolipid *** level of insulin was detected by a mouse enzyme-linked immunosorbent assay(ELISA).Cardiac function was detected by echocardiography,and myocardial pathology was observed by hematoxylin-eosin and Masson *** expression of collagenⅠand collagenⅢwas detected by *** monophosphate-activated protein kinase(AMPK)/Nrf2/heme oxygenase-1(HO-1)signaling pathway was detected by Western blot and ***:Rb1 treatment could improve glucose tolerance and the level of cardiac function indexes,and inhibit the level of oxidative stress indexes and the expression of collagenⅠand collagenⅢ.Moreover,Rb1 treatment enhanced AMPK phosphorylation and increased Nrf2 and HO-1 ***:Rb1 treatment alleviated CIH-induced diabetic cardiomyopathy and glycolipid metabolism disorders in db/db mice by inhibiting oxidative stress and regulating the AMPK/Nrf2/HO-1 signaling pathway.