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Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq Maha Abid Wissal Ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani El-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad Tahir Lysien Zambrano Mumtaz Ali Khan Aun Raza Nagwa Mostafa El-Sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran Elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of FUO.Methods:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,2023.In total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative platform.Only adult patients with confirmed infection as the cause of FUO were included in the study.The severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the study.Overall,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired infections.The most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for diagnosis.The mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not rare.Overall,38(23.8%)patients had at least one of the severity parameters.The mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)patients.Conclusions:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： developing countries Fever of unknown origin Infection

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Nutrition impacts of non-solid cooking fuel adoption on under-five children in developing countries

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Journal of Integrative Agriculture 2024年第2期23卷 397-413页

作者： Yalin Tang Yuhe Guo Gang Xie Chengfang Liu China Center for Agricultural Policy School of Advanced Agricultural SciencesPeking UniversityBeijing 100871China Agricultural Information Institute Chinese Academy of Agricultural SciencesBeijing 100081China

This paper examines the nutrition impacts of using non-solid cooking fuel on under-five children in developing countries.We draw on data from more than 1.12 million children in 62 developing countries from the Demographic and Health Surveys(DHS).Results from both fixed effects(FE)and instrumental variable(IV)estimates show that using non-solid cooking fuel significantly improves the nutrition outcomes of under-five children.Compared with their peers from households mainly using solid fuel,children from households mainly using non-solid fuel exhibit a lower probability of experiencing stunting(by 5.9 percentage points)and being underweight(by 1.2 percentage points).Our further investigation provides evidence for several underlying mechanisms,such as improved indoor air quality,induced reduction in children’s respiratory symptoms,benefits on maternal health,and reduction in maternal time spent on fuel collection or cooking.Heterogenous analyses suggest that the nutrition benefits of using non-solid cooking fuel are more prominent among boys,children above three years old,and those from households of lower socioeconomic status,rural areas,and Southeast Asia.

关键词： non-solid cooking fuel nutrition benefits under-five children developing countries

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Challenges to establishing and maintaining kidney transplantation programs in developing countries:What are the coping strategies?

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World Journal of Methodology 2024年第2期14卷 1-16页

作者： Rabea Ahmed Gadelkareem Amr Mostafa Abdelgawad Nasreldin Mohammed Mohammed Ali Zarzour Mahmoud Khalil Ahmed Reda Hisham Mokhtar Hammouda Department of Urology Assiut Urology and Nephrology HospitalFaculty of MedicineAssiut UniversityAssiut 71515Egypt

Kidney transplantation(KT)is the optimal form of renal replacement therapy for patients with end-stage renal diseases.However,this health service is not available to all patients,especially in developing countries.The deceased donor KT programs are mostly absent,and the living donor KT centers are scarce.Single-center studies presenting experiences from developing countries usually report a variety of challenges.This review addresses these challenges and the opposing strategies by reviewing the single-center experiences of developing countries.The financial challenges hamper the infrastructural and material availability,coverage of transplant costs,and qualification of medical personnel.The sociocultural challenges influence organ donation,equity of beneficence,and regular follow-up work.Low interests and motives for transplantation may result from high medicolegal responsibilities in KT practice,intense potential psychosocial burdens,complex qualification protocols,and low productivity or compensation for KT practice.Low medical literacy about KT advantages is prevalent among clinicians,patients,and the public.The inefficient organizational and regulatory oversight is translated into inefficient healthcare systems,absent national KT programs and registries,uncoordinated job descriptions and qualification protocols,uncoordinated on-site investigations with regulatory constraints,and the prevalence of commercial KT practices.These challenges resulted in noticeable differences between KT services in developed and developing countries.The coping strategies can be summarized in two main mechanisms:The first mechanism is maximizing the available resources by increasing the rates of living kidney donation,promoting the expertise of medical personnel,reducing material consumption,and supporting the establishment and maintenance of KT programs.The latter warrants the expansion of the public sector and the elimination of non-ethical KT practices.The second mechanism is recruiting external resources,including financial,exp

关键词： Challenges Coping strategies developing countries Kidney transplantation Low resources Single-center

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Importance of Wolbachia-mediated biocontrol to reduce dengue in Bangladesh and other dengue-endemic developing countries

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Biosafety and Health 2023年第2期5卷 69-77页

作者： Abdullah Al Noman Debashish Das Zinnatun Nesa Md.Tariquzzaman Fariha Sharzana Md.Rakibul Hasan Baizid Khoorshid Riaz Golam Sharower Mohammad Meshbahur Rahman Department of Genetic Engineering&Biotechnology Jashore University of Science and TechnologyJashore 7408Bangladesh Directorate General of Health Services Government of the People's Republic of Bangladesh Ministry of Health and Family WelfareDhaka 1212Bangladesh Center for Medical Biotechnology Government of the People's Republic of Bangladesh Ministry of Health and Family WelfareDhaka 1212Bangladesh Department of Public Health and Hospital Administration National Institute of Preventive and Social Medicine(NIPSOM)Dhaka 1212Bangladesh Department of Entomology National Institute of Preventive and Social Medicine(NIPSOM)Dhaka 1212Bangladesh Department of Biostatistics National Institute of Preventive and Social Medicine(NIPSOM)Dhaka 1212Bangladesh

Mosquito-borne diseases,particularly dengue and chikungunya have become global threats,infecting millions of people worldwide,including developing countries of Southeast Asia and Latin America.Bangladesh,like many other developing countries,is experiencing frequent dengue outbreaks.This article,therefore,critically discussed the current status of dengue disease,vector control approaches,and the need for Wolbachia-mediated intervention in Bangladesh and other dengue-endemic developing countries.In this narrative review study,rel-evant literature was searched from major databases and search engines such as PubMed,BanglaJol,World Health Organization(WHO)/European Centre for Disease Prevention and Control(ECDC)and Google Scholar.Considering the selection criteria,our search strategies finally involved 55 related literature for further investigation.Findings showed that current vector control strategies could not render protection for an extended period,and the disease burden of arboviruses is increasing.The impoverished outbreak preparedness,urbanization,climate change,and less efficacy of existing control methods have made people susceptible to vector-borne diseases.Hence,Wolbachia,a naturally occurring endosymbiont of many mosquito species that can potentially limit virus transmission through several host genetic alterations,would be a potential alterna-tive for dengue prevention.We also critically discussed the challenges and prospects of Wolbachia-based den-gue control in developing countries.The evidence supporting the efficacy and safety of this intervention and its mechanism have also been elucidated.Empirical evidence suggests that this introgression method could be an eco-friendly and long-lasting dengue control method.This review would help the policymakers and health experts devise a scheme of Wolbachia-based dengue control that can control mosquito-borne diseases,partic-ularly dengue in Bangladesh and other developing countries.

关键词： Wolbachia-based biocontrol Mosquitoes-borne diseases Dengue Biological control developing countries

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The barriers of joining in vitro fertilization programs among infertile couples in developing countries:A scoping review

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Asian pacific Journal of Reproduction 2023年第4期12卷 147-154,I0001-I0003页

作者： Andriana K Dewi Anggi L Wicaksana Muhammad Lutfi Agung Dewanto Department of Obstetrics and Gynecology FK-KMK Universitas Gadjah MadaYogyakartaIndonesia Faculty of Medicine Universitas TarumanagaraJakartaIndonesia Department of Medical Surgical Nursing FK-KMK Universitas Gadjah MadaYogyakartaIndonesia

Objective:To determine the barriers of joining in-vitro fertilization(IVF)programs among infertile couples in developing countries.Methods:This study assessed infertile couples and the barriers or associated factors resulting in delayed decision-making of joining IVF program by searching databases PubMed,ScienceDirect,EBSCO,ClinicalKey,and Cochrane Library from inception until December 31,2021.Additional search strategies were snowballing literature search and citation tracking.Results:Eleven articles were included in the scoping review.The cost was the greatest barrier of joining IVF program.Limited access and lack of assisted reproductive technology centers,few qualified infertility trained staff,insufficient government support,low priority in government policy,along with sociocultural factors,such as religion and false beliefs or myths were also majorly considered to be associated obstacles.Conclusions:The main barrier associated with IVF program among infertile couples in developing countries is the high cost of the IVF services.

关键词： In vitro fertilization Assisted reproductive technology Barrier developing countries

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Effects of taxation on social innovation and implications for achieving sustainable development goals in developing countries: A literature review

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International Journal of Innovation Studies 2022年第4期6卷 259-275页

作者： Jean C.Kouam Simplice A.Asongu Nkafu Policy Institute Opposite College Jesus-MarieSimbockP.O.Box:6402YaoundeCameroon School of Economics University of JohannesburgJohannesburg2092South Africa

In developing countries,taxation is perceived as a brake on economic growth.Indeed,taxes in most of these countries are not sufficiently adapted to the specificity of the taxpayer and often do not consider the weak administrative capacity of the countries in the region.In this context,reforms have been initiated over the last decade to create tax environments that encourage savings,investment,entrepreneurship,and social innovation.This study provides an overview of research on the effects of taxation on social innovation and the corresponding implications for the achievement of Sustainable Development Goals(SDGs)in developing countries,taking three approaches:thematic,chronological,and methodological.Most studies agree that high taxes in business undermine social innovation and thus the achievement of SDGs,as social innovation is known to be a driver of most SDGs and business the vehicle.The majority of the selected studies used primary data collected from samples whose representativeness with respect to the population concerned(notably businesses)is still not explicitly justified.

关键词： Social innovation SDGs developing countries

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Typhoid intestinal perforation in developing countries: Still unavoidable deaths?

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World Journal of Gastroenterology 2017年第11期23卷 1925-1931页

作者： Sandro Contini Department of Surgical Sciences University of Parma43123 ParmaItaly

Typhoid fever is a public health challenge mostly concentrated in impoverished, overcrowded areas of the developing world, with lack of safe drinking and sanitation. The most serious complication is typhoid intestinal perforation(TIP), observed in 0.8% to 39%, with a striking rate difference between high-income and low-middle-income countries. Although the mortality rate consequent to TIP in resource-poor countries is improved in the last decades, it is still fluctuating from 5% to 80%, due to surgical-and not surgical-related constraints. Huge economic costs and long timelines are required to provide a short-to middle-term solution to the lack of safe water and sanitation. Inherent limitations of the currently available diagnostic tools may lead to under-evaluation as well as over-evaluation of the disease, with consequent delayed treatment or inappropriate, excessive antibiotic use, hence increasing the likelihood of bacterial resistance. There is a need for immunization programs in populations at greatest risk, especially in sub-Saharan Africa. Uniform surgical strategies and guidelines, on the basis of sound or prospective surgical studies and adapted to the local realities, are still lacking. Major drawbacks of the surgical treatment are the frequent delays to surgery, either for late diagnosis or for difficult transports, and the unavailable appropriate intensive care units in most peripheral facilities. As a consequence, poor patient's conditions at presentation, severe peritoneal contamination and unsuitable postoperative care are the foremost determinant of surgical morbidity and mortality.

关键词： Typhoid bacterial resistance Typhoid fever Typhoid intestinal perforation developing countries Low-Middle-Income countries Postoperative care Typhoid vaccination

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A local spatial decision support system for developing countries based on MCA,fuzzy sets and OWA–case study of a municipality in Cuba

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Geo-Spatial Information Science 2013年第2期16卷 120-129页

作者： Ricardo DELGADO TELLEZ ZHONG Ershun ZUHU Yang Arisleydis PEÑA DE LA CRUZ Graduate University of Chinese Academy of Sciences No.A19Yuquan RoadBeijing 100049China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchCASNo.A11Datun RoadBeijing 100101China International Business Division SuperMap Software Co.LtdNo.A10Jiuxianqiao North RoadBeijing 100015China Department of Applied Meteorology Cuban Institute of MeteorologyHavana 95100Cuba

This paper presents a Spatial Decision Support System for local governments of developing countries.It allows municipality government,enterprises,scientific community and civil society to address decision problems using GIS.The framework is supported by four modules of information technologies:Environmental Decision Support Database,Data Manipulation,Decision Support,and Mapping.A case study is presented covering the implementation of this framework in one municipality of Cuba.An example of land suitability planning for coconut crops is used to evaluate the system performance and usability.Results show local municipalities are able to use this framework to solve local decision problems using state of the art decision making even with low infrastructure development.

关键词： GIS Spatial Decision Support System MCA OWA developing countries

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Review of global neurosurgery education: Horizon of Neurosurgery in the developing countries

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Chinese Neurosurgical Journal 2020年第3期6卷 178-190页

作者： Y.Kato B.S.Liew A.A.Sufianov L.Rasulic K.I.Arnautovic V.H.Dong I.S.Florian F.Olldashi Y.Makhambetov B.Isam M.Thu Ts.Enkhbayar N.Kumarasinghe A.H.Bajama S.Nair S.Sharif M.R.Sharma J.A.Landeiro C.G.Yampolsky N.M.F.El-Ghandour A.M.Hossain S.Sim S.Chemate Hira Burhan L.Feng H.Andrade Isabelle M.Germano Department of Neurosurgery Fujita Health University Bantane HospitalNagoyaJapan Department of Neurosurgery Hospital Sungai BulohSungai BulohSelangorMalaysia Federal State-Financed Institution“Federal Centre of Neurosurgery”of Ministry of Health of the Russian Federation TyumenRussia I.M.Sechenov First Moscow State Medical University MoscowRussia Faculty of Medicine University of BelgradeBelgradeSerbia Semmes-Murphey Clinic and Department of Neurosurgery University of TennesseeMemphisTNUSA Neurosurgery Center of Viet Duc university hospital HanoiVietnam Department of Neurosurgery University of Medicine and Pharmacy“Iuliu Hatieganu”Cluj-NapocaCluj CountyRomania Department of Neurosurgery University Hospital of TraumaTiranaAlbania National Center of Neurosurgery AstanaKazakhstan Neurosurgical Centre Yangon General HospitalYangoonMyanmar Mongolian Neurosurgical Society UlaabaatarMongolia National Hospital of Sri Lanka ColomboSri Lanka Department of Neurosurgery Dr Soetomo General HospitalAirlangga UniversitySurabayaIndonesia Department of Neurosurgery Sree Chitra Tirunal Institute for Medical Sciences and TechnologyThiruvananthapuramIndia Institute of Postgraduate Studies and Medical Sciences Liaquat National Hospital&Medical CollegeKarachiPakistan Department of Neurosurgery TU Teaching HospitalKathmanduNepal Department of Neurosurgery Universidade Federal FluminenseNiteróiBrazil Department of Neurosurgery Hospital Italiano de Buenos AiresBuenos AiresArgentina Department of Neurosurgery Faculty of MedicineCairo University81 Nasr RoadNasr CityCairoEgypt Bangladesh Society of Neurosurgeons DhakaBangladesh Khema Clinic 18 StreetPhnom Penh 528Cambodia DNB Neurosurgery Apollo HospitalChennaiIndia Institute of Neurosciences Nobel Medical College and Teaching HospitalBiratnagarNepal China International Neuroscience Institute BeijingChina Department of Neurosurgery University Medicine MannheimMannheimGermany Icahn School of Medicine Mount Sinai HospitalNew York CityUSA

Globally,the discipline of neurosurgery has evolved remarkably fast.Despite being one of the latest medical specialties,which appeared only around hundred years ago,it has witnessed innovations in the aspects of diagnostics methods,macro and micro surgical techniques,and treatment modalities.Unfortunately,this development is not evenly distributed between developed and developing countries.The same is the case with neurosurgical education and training,which developed from only traditional apprentice programs in the past to more structured,competencebased programs with various teaching methods being utilized,in recent times.A similar gap can be observed between developed and developing counties when it comes to neurosurgical education.Fortunately,most of the scholars working in this field do understand the coherent relationship between neurosurgical education and neurosurgical practice.In context to this understanding,a symposium was organized during the World Federation of Neurological Surgeons(WFNS)Special World Congress Beijing 2019.This symposium was the brain child of Prof.Yoko Kato-one of the eminent leaders in neurosurgery and an inspiration for female neurosurgeons.Invited speakers from different continents presented the stages of development of neurosurgical education in their respective countries.This paper summarizes the outcome of these presentations,with particular emphasis on and the challenges faced by developing countries in terms of neurosurgical education and strategies to cope with these challenges.

关键词： Global neurosurgical education developing countries

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China’s Outward Foreign Direct Investment and Economic Growth in developing countries

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China Economist 2022年第3期17卷 113-124页

作者：潘春阳吴青山 School of Business East China University of Science and Technology(ECUST)ShanghaiChina

The implementation of China’s open development strategy has unveiled a wave of outward foreign direct investment(OFDI)by Chinese companies,with global implications.Based on panel data from 146 developing countries from 2003 to 2017,we investigate the growth effects of China’s OFDI.We find that China’s OFDI has promoted significant economic growth in developing countries.Not only could China’s OFDI increase GDP per capita of a country in a short time but raise the country’s long-run equilibrium value as well.In addition,the growth effects of China’s OFDI were more significant for countries with weak governance,rich resource,and modest human capital,and were above the average level for Belt and Road Initiative(BRI)countries,African countries,and in the post-crisis era.Our research helps unravel the global significance of Chinese companies investing overseas and contributes to research on the growth effects of direct investment between developing countries.

关键词： Outward foreign direct investment(OFDI) developing countries economic growth China

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