Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention

作     者：Faraz Bishehsari Mahboobeh Mahdavinia Michele Vacca Reza Malekzadeh Renato Mariani-Costantini 

作者机构：Division of Gastroenterology Robert H Lurie Comprehensive Cancer Center Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL 60611 United States Division of Allergy-Immunology Department of Medicine Northwestern University Feinberg School of Medicine Chicago IL 60611 United States Medical Research Council-Human Nutrition Research MRC-HNR Cambridge CB1 9NL United Kingdom Institute of the Metabolic Science IMS Cambridge CB2 0QQ United Kingdom Digestive Oncology Research Center Digestive Disease Research Institute Tehran University of Medical Sciences Shariati Hospital Tehran *** Iran Unit of General Pathology Aging Research Center G. d’Annunzio University Foundation 66100 Chieti Italy Department of Medical Oral and Biotechnological Sciences G. d’Annunzio University 66100 Chieti Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第20期

页      面：6055-6072页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Institutional NRSA,clinical oncology research training program,No.T32 CA079447(Bishehsari F) the Associazione Italiana per la Ricerca sul Cancro(AIRC),Milan to Mariani-Costantini R the Office for Internationalization,G.d’Annunzio University,Chieti the Carichieti Foundation,Chieti Ministero dell’Istruzione,dell’Universitàe della Ricerca(MIUR),Rome,Italy the Fondazione Umberto Veronesi,Milan,Italy and the MRC(5PT57)to Vacca M 

主　　题：Colorectal cancer Developing countries Environment Diet Nuclear receptors Gut microbiota 

摘      要：Colorectal cancer(CRC)is one of the leading causes of cancer and cancer-related mortality *** disease has been traditionally a major health problem in industrial countries,however the CRC rates are increasing in the developing countries that are undergoing economic *** environmental risk factors,mainly changes in diet and life style,have been suggested to underlie the rise of CRC in these *** and lifestyle impinge on nuclear receptors,on the intestinal microbiota and on crucial molecular pathways that are implicated in intestinal *** this respect,the epidemiological transition in several regions of the world offers a unique opportunity to better understand CRC carcinogenesis by studying the disease phenotypes and their environmental and molecular associations in different *** data from these studies may have important implications for the global prevention and treatment of CRC.