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第十五届国际药理学大会

作者： Sheng- tao Yuan Tian-pa You Tao Wang .Zong-gui Wang Xin Fan Lu-yong Zhang.The Drag Screening Center.China Pharmaceutical University.Nanjing.Jiansu.China.University of Science and Technology of China.Hefei Anhui.China.

＜正＞ XY - 8 is a new water - solubility derivate from Camptotecin. which,compared with Camptotecin. appears to be less toxicity and more cytotoxic against human tumor cells. In this study,we report the anticancer activity of XY - 8 on 9 kinds of human tumor including lung carcinoma,stomach carcinoma （2 cell lines）. hepatocarcinoma（2 cell lines）,breast carcinoma,colon carcinoma,leukemia,cervix carcinoma,ovarian cancer and glioblastoma in vitro or in vivo. The average IC50 value of XY - 8 1.22 μM. In contrast,the average IC50 values of Camptotecin were 10.54 μM. The LD50 was 280 mg/kg on mice by iv.. In nude mice,the T/C （ % ） were 44.2 at the dose of 2. 5mg/kg and 53.76 at the dose of 5mg/kg on A - 549 xenograft,the T/C （ % ） were 27.3 at the dose of 2. 5mg/kg and 36. 6 at the dose of 5mg/kg on BGC - 823 xenograft,the T/C （ % ） were 43.3 at the dose of 2. 5mg/kg and 48.9 at the dose of 5mg/kg on SGC - 7901 xenograft, . The results showed that XY - 8 had strong growth inhibition of human tumor in vitro and in vivo and may be useful in human tumor chemotherapy duo to its water - solubility and less toxicity.

关键词： anticancer activity Camptotecin derivate in vivo

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Two-photon spectroscopic behaviors and photodynamic effect on the BEL-7402 cancer cells of the new chlorophyll photosensitizer

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Science China Chemistry 2008年第6期51卷 529-538页

作者： ZHAO PeiDe1,2,CHEN Ping1,TANG GuoQing1,LIU JinWei2,LIN Lie1,GUO Peng1,YU Qing2, YAO JianZhong3,MA DongMing4,ZHANG GuiLan1 & CHEN WenJu1 1 Key Laboratory of Optoelectronic Information Science and Technology,Ministry of Education,Institute of Modern Optics,Nankai University,Tianjin 300071,China 2 Department of Physics,Hebei University of Technology,Tianjin 300130,China 3 College of Pharmacy,Second Military Medical University,Shanghai 200433,China 4 Tianjin College of the Traditional Chinese Medicine,Tianjin 300193,China Key Laboratory of Optoelectronic Information Science and Technology Ministry of Education Institute of Modern Optics Nankai University Tianjin China Department of Physics Hebei University of Technology Tianjin China College of Pharmacy Second Military Medical University Shanghai China Tianjin College of the Traditional Chinese Medicine Tianjin China

The spectroscopic properties of a new chlorophyll derivate photosensitizer (CDP) are studied under the excitation wavelengths at 800 and 400 nm using femtosecond pulses from a Ti: sapphire laser. The damaging effect of CDP on the BEL-7402 cancer cells is also investigated upon two-photon illumination at 800 nm. The normalized fluorescence spectra of CDP in tetrahydrofuran (THF) show that two-photon and one-photon spectra have the same distributions and the same emission bands (675 nm). The lifetimes of two- and one-photon induced fluorescence of this molecule are of the order of 5.0 ns. By comparing the data it is shown that there is some difference between the two lifetimes, but the difference is less than one nanosecond. The two-photon absorption cross section of the molecule is also measured at 800 nm and estimated as about σ'_2 ≈ 31.5x10^(-50)cm^4·s·photon^(-1). The results of two-photon photodynamic therapy (TPPDT) tests show that CDP can kill all of the tested cancer cells according to the usual Eosine assessment. Our results indicate that the two-photon-induced photophysical, photochemical and photosensitizing processes of CDP may be basically similar to those of one-photon excitation. These behaviors of the sample suggest that one may find other possible methods to estimate some photosensitizers' effects in details such as their distribution in cells and the reactive targets of the sub-cellular parts of some tumor cells via two-photon excitation techniques.

关键词： photosensitizer chlorophyll derivate two-photon fluorescence two-photon absorption cross-section TPPDT BEL-7402 cell

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NONCONICAL NONSMOOTH MULTIOBJECTIVE PROGRAMMING-OPTIMALITY CONDITIONS AND

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Systems Science and Mathematical Sciences 1998年第1期11卷 61-68页

作者： DUALITY THEOREMSLI Yuan-xi(Departtnent of Statistics and OR, Fudan University, Shanghai 200433, China)

This paper deals with Nonconical Nonsmooth Multiobjective ProgrammingProblem. The generalized directional derivate of a maPping w.r.t a binary relation andthe derivate of a binary relation are illtroduced and used as ... 详细信息

关键词： Binary relation generalized directional derivate derivate of a binary relation multiobjective programming optimality condition duality theorem.

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In Situ Coupling Strategy for Anchoring Monodisperse Co_9S_8 Nanoparticles on S and N Dual?Doped Graphene as a Bifunctional Electrocatalyst for Rechargeable Zn–Air Battery

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Nano-Micro Letters 2019年第1期11卷 64-77页

作者： Qi Shao Jiaqi Liu Qiong Wu Qiang Li Heng?guo Wang Yanhui Li Qian Duan School of Materials Science and Engineering Changchun University of Science and Technology

An in situ coupling strategy to prepare Co_9S_8/S and N dual?doped graphene composite(Co_9S_8/NSG) has been proposed. The key point of this strategy is the function?oriented design of organic compounds. Herein, cobalt porphyrin derivatives with sulfo groups are employed as not only the coupling agents to form and anchor Co_9S_8 on the graphene in situ, but also the heteroatom?doped agent to generate S and N dual?doped graphene. The tight coupling of multiple active sites endows the composite materials with fast electrochemical kinetics and excellent stability for both oxygen reduction reaction(ORR) and oxygen evolution reaction(OER). The obtained electrocatalyst exhibits better activity parameter(ΔE = 0.82 V) and smaller Tafel slope(47.7 mV dec^(-1) for ORR and 69.2 mV dec^(-1) for OER) than commercially available Pt/C and RuO_2. Most importantly, as electrocatalyst for rechargeable Zn–air battery, Co_9S_8/NSG displays low charge–discharge voltage gap and outstanding long?term cycle stability over 138 h compared to Pt/C–RuO_2. To further broaden its application scope, a homemade all?solid?state Zn–air battery is also prepared, which displays good charge–discharge performance and cycle performance. The function?oriented design of N_4?metallomacrocycle derivatives might open new avenues to strategic construction of high?performance and long?life multifunctional electrocatalysts for wider electro?chemical energy applications.

关键词： In situ coupling strategy Porphyrin derivate Doped graphene Metal sulfide Bifunctional electrocatalyst Rechargeable Zn–air battery

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