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Effect of Chronic Administration of Cadmium on Anxiety-like, depression-like and Memory Deficits in Male and Female Rats: Possible Involvement of Oxidative Stress Mechanism

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Journal of Behavioral and Brain Science 2018年第5期8卷 240-268页

作者： Mouloud Lamtai Jihane Chaibat Sihame Ouakki Inssaf Berkiks El-Housseine Rifi Aboubaker El Hessni Abdelhalem Mesfioui Ali Tadlaoui Hbibi Hassna Ahyayauch Azzouz Essamri Ali Ouichou Unit of Nervous and Endocrine Physiology Laboratory of Genetics Neuroendocrinology and Biotechnology Faculty of Science University Ibn Tofail Kenitra Morocco Laboratory of Synthesis Organic and Extraction Processes Department of Chemistry Faculty of Science University Ibn Tofail Kenitra Morocco Institut Supé rieur des Professions Infirmiè res et Techniques de Santé (ISPISTS) route Casablanca Rabat Morocco Laboratory of Agro-Resources and Process Engineering Faculty of Science University Ibn Tofail Kenitra Morocco

The main objective of this work is to study the effect of chronic administration of cadmium (Cd) on the level of depression-like, anxiety-like, memory state and oxidative stress in male and female Wistar rats. For this purpose, this study was conducted with 24 rats for each gender. Four groups were constituted: (Group 1: Control): received saline solution NaCl (0.9%), (Group 2: Cd-0.25;Group 3: Cd-0.5;Group 4: Cd-1): received daily 0.25 mg/kg, 0.5 mg/kg and 1 mg/kg of Cd respectively during 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. The Y maze was used to evaluate the working memory and the Morris Water Maze, to evaluate space learning and spatial memory. The results revealed that in males, all doses of Cd provoke depression-like, while in females only the group treated with 1 mg/kg Cd shows elevated depression-like behavior. In regard to anxiety-like behavior, Cd induces an anxiogenic effect in both genders tests. In the Y-Maze test, both males and females expressed a low percentage of alternations, suggesting that working memory was affected by Cd at 1 mg/kg. In the Morris Water Maze test, the space learning and spatial memory were significantly impaired in the group Cd-1. Neurochemical analysis showed that levels of nitric oxide and lipid peroxidation in the hippocampus were significantly increased after Cd treatments. Overall analysis of our data revealed that Cd caused significant alterations in the examined parameters that were sex-dependent and dose-dependent.

关键词： Cadmium depression-like Anxiety-like Memory Oxidative Stress

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Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress

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Neural Regeneration Research 2020年第6期15卷 1150-1159页

作者： Yun-Ling Huang Ning-Xi Zeng Jie Chen Jie Niu Wu-Long Luo Ping Liu Can Yan Li-Li Wu Research Center for Basic Integrative Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Department of Pharmacology PLA General HospitalBeijingChina

The depression-like behavior phenotype,neurogenesis in the dentate gyrus and miR-124 expression in the hippocampus are the focus of current research on the pathogenesis of depression and antidepressant therapy.The present study aimed to clarify the dynamic changes of depression-like behavior,dentate gyrus neurogenesis and hippocampal miR-124 expression during depression induced by chronic stress to reveal pathological features at different stages of depression and to further provide insight into depression treatment.Chronic unpredictable mild stress depression models were established by exposing Sprague-Dawley rats to various mild stressors,including white noise,thermal swimming,stroboscopic illumination,soiled cages,pairing with three other stressed animals,cold swimming,tail pinch,restraint and water and food deprivation.Chronic unpredictable mild stress model rats underwent dynamic observation from 1 to 8 weeks and were compared with a control group(normal feeding without any stressors).To observe changes in the depression-like behavior phenotype during chronic unpredictable mild stress-induced depression,a sucrose preference test was used to evaluate the degree of anhedonia.An open-field test was used to evaluate locomotor activity and anxiety status.Compared with the control group,chronic unpredictable mild stress rats lost weight but did not have a depression-like behavioral phenotype at 1-4 weeks.Chronic unpredictable mild stress rats presented decreased sucrose preference and locomotor activity at 5-8 weeks.In addition,chronic unpredictable mild stress rats did not have significant anxiety-like behavior during 1-8 weeks of modeling.To observe neurogenesis dysfunctions and changes in neuronal number in the dentate gyrus during chronic unpredictable mild stress-induced depression,markers(DCX and DCX/BrdU)of neural proliferation and differentiation and the neuronal marker NeuN were assessed by immunofluorescence.Compared with the control group,neurogenesis and the neuronal number in the dentate gyrus did not

关键词： chronic unpredictable mild stress model continuous observation depression depression-like behavior dynamic changes hippocampus miR-124 neurogenesis dysfunction neuronal loss

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Affective Behavior Dysregulation Was Induced by Chronic Administration of Copper in Wistar Rats

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Neuroscience & Medicine 2019年第2期10卷 134-149页

作者： Mouloud Lamtai Sihame Ouakki Oussama Zghari Abdelhalem Mesfioui Aboubaker El Hessni Ali Ouichou Unit of Nervous and Endocrine Physiology Laboratory of Genetics Neuroendocrinology and Biotechnology Faculty of Science University Ibn Tofail Kenitra Morocco

As both deficiency and excess of copper (Cu) can be harmful, dysregulation in its homeostasis has been connected with various neurological disorders. The present study was undertaken to examine whether Cu chronic administration can induce alterations of affective behavior especially anxiety and depression levels in male and female rats. Twenty-four rats, for each gender, divided in control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or CuCl2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. Results demonstrated that Cu administered chronically, exerts an anxiogenic effect in rats. In the OFT, Cu decreases the TCA and NRC parameters without modifying the locomotor activity represented by the NTS parameter. With regard to EPM, Cu decreases TOA and EOA parameters without modifying the TAE parameter. A significant increase in depression-like symptoms was also exhibited by Cu treated rats (p 2 showed maximum anxiety-like and depression-like symptoms as compared to controls as well as from the other two doses indicating dose-dependent effects of chronic Cu administration. Overall, these results suggest that intoxication with Cu has potentially deleterious effects on brain as reflected in behavioral dysfunctions such as depression and anxiety.

关键词： Copper depression-like Anxiety-like Rat

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