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南充地区妊娠期妇女血清维生素d水平的相关性研究

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中国科技期刊数据库医药 2024年第4期 0171-0177页

作者：范金银张又文李秋霞范波川北医学院附属医院产科四川南充637000

了解南充地区妊娠期妇女维生素d水平,以及在各年龄、季节、孕周之间的分布和对母体及妊娠结局的影响,为南充地区妊娠期妇女科学、合理补充相关维生素提供参考依据。方法选取2017年10月1日至2022年4月30日在川北医学院附属医院门诊产检... 详细信息

了解南充地区妊娠期妇女维生素d水平,以及在各年龄、季节、孕周之间的分布和对母体及妊娠结局的影响,为南充地区妊娠期妇女科学、合理补充相关维生素提供参考依据。方法选取2017年10月1日至2022年4月30日在川北医学院附属医院门诊产检并于孕期完善维生素检查,且住院分娩的符合纳入标准的本地孕妇2922例,采用高效液相色谱-串联质谱法检测孕妇血清维生素d值,将数据按照孕期、年龄、季节等可能影响维生素水平的因素进行分组。结果孕妇妊娠早、中、晚期血清维生素d水平总体异常率81.07%,以缺乏为主要表现(52.94%),缺乏率在妊娠晚期(32.10%)小于妊娠早期(63.20%)及妊娠中期(44.03%),随着孕周增加,维生素d异常率在逐渐降低,且缺乏占比也在逐渐降低;在不同季节,夏季血清维生素d水平显著高于其他季节。随着年龄增加,维生素d水平逐渐升高。维生素d缺乏的孕妇在妊娠期糖尿病的发生率低于维生素d正常的孕妇。结论对于妊娠期妇女,应定期监测维生素水平,特别注意孕早期维生素d缺乏现象,减少因维生素异常所导致的孕妇并发症、胎儿发育不良及先天缺陷等的发生。

关键词：妊娠期维生素 d 缺乏妊娠相关疾病

HPLC测定化妆品中二氢燕麦生物碱d的含量

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香料香精化妆品 2024年第5期 139-143页

作者：陈丽林梦感邓昊谢智勇仁和全域(上海)大健康研究院有限公司上海200062

采用高效液相色谱法(HPLC)测定化妆品中二氢燕麦生物碱d的含量。色谱柱:Agilent Zorbax SB-Aq(250 mm×4.6 mm×5µm);流动相为V磷酸(体积分数0.05%)∶V乙腈=67∶33;流速:1.0 mL/min;柱温:30℃;检测波长:220 nm。结果表明,二氢燕麦生物... 详细信息

采用高效液相色谱法(HPLC)测定化妆品中二氢燕麦生物碱d的含量。色谱柱:Agilent Zorbax SB-Aq(250 mm×4.6 mm×5µm);流动相为V磷酸(体积分数0.05%)∶V乙腈=67∶33;流速:1.0 mL/min;柱温:30℃;检测波长:220 nm。结果表明,二氢燕麦生物碱d在0.0114~0.2850μg与其峰面积呈良好线性关系(R=0.9999);液态类样品平均回收率为99.01%,相对标准偏差(RSd)为1.96%(n=9);膏霜样品的平均回收率为102.68%,RSd为2.46%(n=9);乳液样品的平均回收率为99.96%,RSd为1.4%(n=9)。该法简便、准确可行,可用于化妆品中二氢燕麦生物碱d的含量测定及质量控制。

关键词：化妆品二氢燕麦生物碱 d 高效液相色谱法

A Series of Rare Earth Phenolates Substituted by Alkyl Groups for d,L-Lactide Ring-Opening Polymerization

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Journal of Wuhan University of Technology(Materials Science) 2011年第5期26卷 939-944页

作者：王艳张丽芳 Institute of Material Chemistry Shanxi Normal University

Single component rare earth phenolates substituted by various alkyl groups have been prepared and the correlation between the aryloxides＇ structure and catalytic activity in the ring-opening polymerization of d,L-lactide has also been *** catalytic activity of all rare earth aryloxides,characteristics of the ring-opening polymerization as well as polymerization kinetics and mechanism were *** results showed that both phenolates＇ catalytic activities and polymerization characteristics changed regularly,keeping in good concordance with variations in substitutents＇ number on phenol and structure of aryloxide *** stronger ability of electron-donation of alkyl groups,the higher catalytic ***,the more numbers of substituted alkyl on phenyl ring,the higher catalytic *** analyses of polymer ends revealed that the polymerization proceeded via a coordination-acyl-oxygen bond cleavage-insertion mechanism.

关键词： ring-opening polymerization d L-lactide rare earth phenolates

The effect of vitamin d on sperm motility and the underlying mechanism

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Asian Journal of Andrology 2019年第4期21卷 400-407页

作者： Kadiliya Jueraitetibaike Zheng ding dan-dan Wang Long-Ping Peng Jun Jing Li Chen Xie Ge Xu-Hua Qiu Bing Yao Center of Reproductive Medicine Nanjing Jinling Hospital Clinical School of Medical College Nanjing University Nanjing 210002 China The Affiliated Jiangning Hospital of Nanjing Medical School Nanjing 210000 China Urology department Shunde Hospital of Southern Medical University Foshan 528300 China

Vitamin d deficiency is a common health issue around the world. We therefore evaluated the associations of semen quality with both serum and seminal plasma vitamin d levels and studied the mechanisms underlying these by incubating spermatozoa with 1,25(OH)2d in vitro. Two hun dred and twenty-two men were in eluded in our study. Vitamin d was detected using an electrochemilumi nesce nee method. Spermatozoa used for in vitro experiments were isolated by density gradient centrifugation. Positive relationships of serum 25(OH)d with semen volume and seminal plasma fructose were identified. Seminal plasma 25(OH)d level showed no relationship with serum 25(OH)d level, while it was inversely associated with sperm concentration and positively correlated with semen volume and sperm kinetic values. In vitro, sperm kinetic parameters in creased after in cubation with 1,25(OH)2d, especially upon in cubation for 30 min with it at a concen tration of 0.1 nmol l-1. Under these in cubation conditions, the upward migratio n of spermatozoa in creased remarkably with increasing ade nosine triphosphate (ATP) con centratio n. The concentrati on of cyclic ade nosine mono phosphate (cAMP) and the activity of protei n kinase A (PKA) were both elevated, and the PKA inhibitor, N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride (H89) reversed the in crease of ATP producti on. The conce ntrations of cytoplasmic calcium ions and n icotinamide adenine dinucleotide (NAdH) were both enhanced, while mitochondrial calcium uniporter (MCU) inhibitor, Ruthenium 360 (Ru360) did not reverse the increase of ATP production. Therefore, seminal plasma vitamin d may be invoIved in regulating sperm motility, and 1,25(OH)2d may enhance sperm motility by promoting the synthesis of ATP both through the cAMP/PKA pathway and the in crease in in tracellular calcium ions.

关键词： ade no sine triphosphate semi nal plasma sperm motility vitamin d

Repurposing vitamin d for treatment of human malignancies via targeting tumor microenvironment

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Acta Pharmaceutica Sinica B 2019年第2期9卷 203-219页

作者： Xu Wu Wei Hu Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao Lin Zhang Hanyu Zhang Xiaobing Li Wanping Li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing Li Laboratory of Molecular Pharmacology Department of Pharmacology School of Pharmacy Southwest Medical University department of Gastroenterology Shenzhen Hospital Southern Medical University Sichuan Industrial Institute of Antibiotics Chengdu University department of Gastrointestinal Surgery The Affiliated Hospital of Southwest Medical University department of Anaesthesia and Intensive Care The Chinese University of Hong Kong State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macao

Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular *** epidemiological and clinical studies strongly support that vitamin d supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin d not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin d. Notably, wesummarized and discussed the anticancer action of vitamin d in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin d in cancer. We presently re-propose vitamin d to be a novel and economical anticancer agent.

关键词： Vitamin d 1α,25-dihydroxyvitamin d3 Tumor microenvironment Cancer stem cell Tumor-infiltrating lymphocyte Tumor-derived endothelial cell Cancer-associated fibroblast

Effect of vitamin d treatment in children with attention-deficit hyperactivity disorder

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World Journal of Pediatrics 2019年第1期15卷 78-84页

作者： Nadia dehbokri Gholamreza Noorazar Aida Ghaffari Gita Mehdizadeh Parvin Sarbakhsh Saba Ghaffary Faculty of Pharmacy Tabriz University of Medical SciencesTabrizIran Research Center of Psychiatry and Behavioral Sciences Tabriz University of Medical SciencesTabrizIran Pediatrics Health Research Center Tabriz University of Medical SciencesTabrizIran Road Traffic Injury Research Center Tabriz University of Medical SciencesTabrizIran department of Pharmacotherapy Drug Applied Research CenterTabriz University of Medical SciencesTabrizIran

Background In this research the symptom improvement of attention-deficit hyperactivity disorder (AdHd) of children was assessed by oral vitamin d administration in Tabriz,*** In this double-blind,randomized clinical trials,96 children (2-18 years) were enrolled to placebo and vitamin d *** took vitamin d pearl (50,000 IU/week) or placebo for 6 ***,who had the change in methylphenidate dosage and received any anticonvulsants and corticosteroids were excluded from the *** symptoms were diagnosed by Conners parent rating scale (CPRS) test at baseline and after *** Conners divided into inattention (IA),hyperactivity/impulsivity (H/I) and combination type (C) *** d serum level was assessed at baseline and after 8 weeks in both *** The differences between CPRS and its subscales were not significant at baseline (P > 0.05).The Conners IA score was decreased in vitamin d group (P djusted with age and baseline values).AdHd Conners and all subscale scores reduced remarkably after intervention in patients with insufficient level of vitamin d compared to placebo (P d improved AdHd symptoms with a particular effect on inattention *** addition,symptoms related to all subscales were improved remarkably in patients with insufficient level of vitamin *** d treatment in children with AdHd could be considered due to the expand benefit of vitamin d in body.

关键词： Attention-deficit hyperactivity disorder Children Conners parent rating scale Vitamin d

Secalonic acid d induces cell apoptosis in both sensitive and ABCG2-overexpressing multidrug resistant cancer cells through upregulating c-Jun expression

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Acta Pharmaceutica Sinica B 2019年第3期9卷 516-525页

作者： Hong Zhang Liyan Huang Liyang Tao Jianye Zhang Fang Wang Xu Zhang Liwu Fu Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteGuangzhou510060China School of Pharmaceutical Sciences Guangzhou Medical UniversityGuangzhou511436China

Secalonic acid d(SAd) could inhibit cell growth in not only sensitive cells but also multidrug resistant(MdR) cells. However, the molecular mechanisms need to be elucidated. Here, we identified that SAd possessed potent cytotoxicity in 3 pairs of MdR and their parental sensitive cells including S1-MI-80 and S1,H460/MX20 and H460, MCF-7/AdR and MCF-7 cells. Furthermore, SAd induced cell G2/M phase arrest via the downregulation of cyclin B1 and the increase of CdC2 phosphorylation. Importantly, JNK pathway upregulated the expression of c-Jun in protein level and increased c-Jun phosphorylation induced by SAd, which was linked to cell apoptosis via c-Jun/Src/STAT3 pathway. To investigate the mechanisms of upregulation of c-Jun protein by SAd, the mR NA expression level and degradation of c-Jun were examined. We found that SAd did not alter the mR NA level of c-Jun but inhibited its proteasome-dependent degradation. Taken together, these results implicate that SAd induces cancer cell death through c-Jun/Src/STAT3 signaling axis by inhibiting the proteasome-dependent degradation of c-Jun in both sensitive cells and ATP-binding cassette transporter sub-family G member 2(ABCG2)-mediated MdR cells.

关键词： Multidrug resistance Secalonic acid d Apoptosis c-Jun ABCG2

Convergence of neutral type proportional-delayed HCNNs with d operators

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International Journal of Biomathematics 2019年第1期12卷 33-41页

作者： Yanli Xu Jiaming Zhong School of Mathematics Finance Xiangnan University ChenzhouHunan 423000P.R.China

This paper is concerned with neutral type high-order cellular neural networks(HCNNs)involving proportional delays and d *** criteria are established for the global exponential convergence of the addressed models by using differential inequality ***,an example and its numerical simulations are employed to illustrate the main results.

关键词： Exponential convergence neutral type high-order cellular neural networks proportional delay d operator

Enhancement of vitamin A combined vitamin d supplementation on immune response to Bacille Calmette-Guerin vaccine revaccinated in Chinese infants

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 130-135页

作者： Ying Zheng Xue-Gang Li Qiu-Zhen Wang Ai-Guo Ma Ib Christian Bygbjerg Yong-Ye Sun Yong Li Ming-Ci Zheng Xi Wang Institute of Human Nutrition Medical College of Qingdao Unirersity department of International Health University of Copenhagen department of Pediatrics.Guilin Medical College Affiliated Hospital department of Orthopaedic Surgery The Sixth Affiliated Hospital of Sun Yat-sen University

Objective:To investigate whether there is an association between diameter of bacille CalmetteGuerin(BCG)sears and effect of purified protein derivative(PPd)reaction anil to determine whether vitamin A(VA)combined vitamin I)(Vd)supplementation influences the immune response to BCG revueeinated in Chinese ***:A cross-section and 3-month community-randomised trial was conducted.A total of 5 629 infants at 3,6 and 12 months of age in Junan County of China were examined for BCG scar ***,597 revuccinated infants were randomly assigned to supplementation(n=307)and control(n=290)*** supplementation group were daily assigned to 1 500 IU VA and 500 IU Vd for 3 *** all infants were subjected to skin test with ***:The diameter of BCG sears was positively con-elated with diameter of skin indurations of PPd(r=0.17,Pd response for the supplementation group compared with that for the control group was 1.07(95%CI 1.01-1.13)for the males and 1.08(95%CI 1.00-1.17)for the *** the supplementation group,the males got larger tuberculin induration than the females[(0.73±0.2l)cm versus(0.67±0.20)cm.Pdiameter of BCG scars was effectively correlated with PPd response,which indicates BCG scar formation may be an useful tool Io evaluate the effect of tuberculosis *** combined Vd supplementation may play an immunoregulatory rale in BCG *** may contribute to the prevention of childhood tuberculosis.

关键词： Tuberculosis Bacille Calmette-Guerin Purified protein derivative Vitamin A Vitamin d Revaccination