Enhancement of vitamin A combined vitamin D supplementation on immune response to Bacille Calmette-Guerin vaccine revaccinated in Chinese infants

作     者：Ying Zheng Xue-Gang Li Qiu-Zhen Wang Ai-Guo Ma Ib Christian Bygbjerg Yong-Ye Sun Yong Li Ming-Ci Zheng Xi Wang 

作者机构：Institute of Human NutritionMedical College of Qingdao Unirersity Department of International HealthUniversity of Copenhagen Department of Pediatrics.Guilin Medical College Affiliated Hospital Department of Orthopaedic SurgeryThe Sixth Affiliated Hospital of Sun Yat-sen University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第2期

页      面：130-135页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：funded by National Natural Science Foundation of China(81172662) Specialized Research Fond for the Doctoral Program of Higher Education(20123706110004) 

主　　题：Tuberculosis Bacille Calmette-Guerin Purified protein derivative Vitamin A Vitamin D Revaccination 

摘      要：Objective:To investigate whether there is an association between diameter of bacille CalmetteGuerin(BCG)sears and effect of purified protein derivative(PPD)reaction anil to determine whether vitamin A(VA)combined vitamin I)(VD)supplementation influences the immune response to BCG revueeinated in Chinese ***:A cross-section and 3-month community-randomised trial was conducted.A total of 5 629 infants at 3,6 and 12 months of age in Junan County of China were examined for BCG scar ***,597 revuccinated infants were randomly assigned to supplementation(n=307)and control(n=290)*** supplementation group were daily assigned to 1 500 IU VA and 500 IU VD for 3 *** all infants were subjected to skin test with ***:The diameter of BCG sears was positively con-elated with diameter of skin indurations of PPD(r=0.17,P0.05)in the 5 629 *** rate of positive response to PP1)was higher in the supplementation group than in the control group(96.1%versus 89.7%,P0.05,prevalence ratio 1.07.95%CI 1.02-1.12).The prevalence ralio of PPD response for the supplementation group compared with that for the control group was 1.07(95%CI 1.01-1.13)for the males and 1.08(95%CI 1.00-1.17)for the *** the supplementation group,the males got larger tuberculin induration than the females[(0.73±0.2l)cm versus(0.67±0.20)cm.P0.05)after ***:The diameter of BCG scars was effectively correlated with PPD response,which indicates BCG scar formation may be an useful tool Io evaluate the effect of tuberculosis *** combined VD supplementation may play an immunoregulatory rale in BCG *** may contribute to the prevention of childhood tuberculosis.