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Parathyroid hormone increases alveolar bone homoeostasis during orthodontic tooth movement in rats with periodontitis via crosstalk between STAT3 and β-catenin

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International Journal of Oral Science 2020年第4期12卷 356-366页

作者： Cheng Zhang Tiancheng Li Chenchen Zhou Li Huang Yuyu Li Han Wang Peipei Duan Shujuan Zou Li Mei State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina Discipline of Orthodontics Faculty of DentistryDepartment of Oral SciencesSir John Walsh Research InstituteUniversity of OtagoOtagoNew Zealand

Periodontitis patients are at risk of alveolar bone loss during orthodontic treatment.The aim of this study was to investigate whether intermittent parathyroid hormone(1–34)treatment(iPTH)could reduce alveolar bone loss during orthodontic tooth movement(OTM)in individuals with periodontitis and the underlying mechanism.A rat model of OTM in the context of periodontitis was established and alveolar bone loss was observed.The control,iPTH and iPTH+stattic groups received injections of vehicle,PTH and vehicle,or PTH and the signal transducer and activator of transcription 3(STAT3)inhibitor stattic,respectively.iPTH prevented alveolar bone loss by enhancing osteogenesis and suppressing bone resorption in the alveolar bone during OTM in rats with periodontitis.This effect of iPTH was along with STAT3 activation and reduced by a local injection of stattic.iPTH promoted osteoblastic differentiation and might further regulate the Wnt/β-catenin pathway in a STAT3-dependent manner.The findings of this study suggest that iPTH might reduce alveolar bone loss during OTM in rats with periodontitis through STAT3/β-catenin crosstalk.

关键词： STAT3 period crosstalk

The crosstalk between autophagy and ferroptosis:what can we learn to target drug resistance in cancer?

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Cancer Biology & Medicine 2019年第4期16卷 630-646页

作者： Yulu Zhou Yong Shen Cong Chen Xinbing Sui Jingjing Yang Linbo Wang Jichun Zhou Department of Surgical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Provinee Hangzhou 310016China Department of Breast Surgery First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China Department of Medical Oncology Holistic Integrative Oncology Institutes and Holistic Integrative Cancer Center of Traditional Chinese and Western MedicineThe Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhou 310012China Department of Cancer Pharmacology Holistic Integrative Pharmacy InstitutesCollege of MedicineHangzhou Normal UniversityHangzhou 310012China Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Provinee and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Provinee Hangzhou Normal UniversityHangzhou 310012China

Autophagy is a conserved intracellular degradation system that plays a dual role in cell death;thus,therapies targeting autophagy in cancer are somewhat controversial.Ferroptosis is a new form of regulated cell death featured with the iron-dependent accumulation of lethal lipid ROS.This pathway is morphologically,biochemically and genetically distinct from other forms of cell death.Accumulating studies have revealed crosstalk between autophagy and ferroptosis at the molecular level.In this review,we summarize the mechanisms of ferroptosis and autophagy,and more importantly,their roles in the drug resistance of cancer.Numerous connections between ferroptosis and autophagy have been revealed,and a strong causal relationship exists wherein one process controls the other and can be utilized as potential therapeutic targets for cancer.The elucidation of when and how to modulate their crosstalk using therapeutic strategies depends on an understanding of the fine-tuned switch between ferroptosis and autophagy,and approaches designed to manipulate the intensity of autophagy might be the key.

关键词： Autophagy ferroptosis crosstalk cancer drug resistance

Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors

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Cellular & Molecular Immunology 2020年第5期17卷 496-506页

作者： Lu Wang Zhilan Liu Lili Wang Qielan Wu Xiang Li Di Xie Huimin Zhang Yongdeng Zhang Lusheng Gu Yanhong Xue Ting Yue Gang Liu Wei Ji Haiming Wei Tao Xu Li Bai Division of Life Sciences and Medicine Department of Oncology of The First Affiliated HospitalThe CAS Key Laboratory of Innate Immunity and Chronic DiseaseUniversity of Science and Technology of China230027 HefeiChina National Key Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of Sciences100101 BeijingChina School of Life Sciences University of Science and Technology of China230027 HefeiChina National Synchrotron Radiation Laboratory University of Science and Technology of China230027 HefeiChina

The spatiotemporal distribution of cytokines orchestrates immune responses in vivo,yet the underlying mechanisms remain to be explored.We showed here that the spatial distribution of interleukin-4(IL4)in invariant natural killer T(iNKT)cells regulated crosstalk between iNKT cells and dendritic cells(DCs)and controlled iNKT cell-mediated T-helper type 1(Th1)responses.The persistent polarization of IL4 induced by strong lipid antigens,that is,α-galactosylceramide(αGC),caused IL4 accumulation at the immunological synapse(IS),which promoted the activation of the IL4R-STAT6(signal transducer and activator of transcription 6)pathway and production of IL12 in DCs,which enhanced interferon-γ(IFNγ)production in iNKT cells.Conversely,the nonpolarized secretion of IL4 induced by Th2 lipid antigens with a short or unsaturated chain was incapable of enhancing this iNKT cell-DC crosstalk and thus shifted the immune response to a Th2-type response.The nonpolarized secretion of IL4 in response to Th2 lipid antigens was caused by the degradation of Cdc42 in iNKT cells.Moreover,reduced Cdc42 expression was observed in tumorinfiltrating iNKT cells,which impaired IL4 polarization and disturbed iNKT cell-DC crosstalk in tumors.

关键词： Spatial distribution Polarization IL4 iNKT DC crosstalk Tumor

Anisotropic leaky-like perturbation with subwavelength gratings enables zero crosstalk

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Light(Science & Applications) 2023年第6期12卷 1153-1161页

作者： Md Faiyaz Kabir Md Borhan Mia Ishtiaque Ahmed Nafiz Jaidye Syed Z.Ahmed Sangsik Kim Department of Electrical and Computer Engineering Texas Tech UniversityLubbockTX 79409USA Department of Physics and Astronomy Texas Tech UniversityLubbockTX 79409USA School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141South Korea

Electromagnetic coupling via an evanescent field or radiative wave is a primary characteristic of light,allowing optical signal/power transfer in a photonic circuit but limiting integration density.A leaky mode,which combines both evanescent field and radiative wave,causes stronger coupling and is thus considered not ideal for dense integration.Here we show that a leaky oscillation with anisotropic perturbation rather can achieve completely zero crosstalk realized by subwavelength grating(SWG)metamaterials.The oscillating fields in the SWGs enable coupling coefficients in each direction to counteract each other,resulting in completely zero crosstalk.We experimentally demonstrate such an extraordinarily low coupling between closely spaced identical leaky SWG waveguides,suppressing the crosstalk by≈40 dB compared to conventional strip waveguides,corresponding to≈100 times longer coupling length.This leaky-SWG suppresses the crosstalk of transverse–magnetic(TM)mode,which is challenging due to its low confinement,and marks a novel approach in electromagnetic coupling applicable to other spectral regimes and generic devices.

关键词： crosstalk coupling enable

Time-dependent crosstalk effects for image sensors with different isolation structures

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Chinese Physics B 2018年第8期27卷 640-644页

作者：沈磊刘力桥郝好杜刚刘晓彦 Institute of Microelectronics Peking University

Photo-generated carriers may diffuse into the adjacent cells to form the electrical crosstalk, which is especially no- ticeable after the pixel cell size has been scaled down. The electrical crosstalk strongly depends on the structure and electrical properties of the photosensitive areas. In this work, time-dependent crosstalk effects considering different isola- tion structures are investigated. According to the different depths of photo-diode （PD） and isolation structure, the transport of photo-generated carriers is analyzed with different regions in the pixel cell. The evaluation of crosstalk is influenced by exposure time. crosstalk can be suppressed by reducing the exposure time. However, the sensitivity and dynamic range of the image sensor need to be considered as well.

关键词： image sensor crosstalk pixel isolation

crosstalk of HgCdTe LWIR n-on-p diode arrays

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Journal of Semiconductors 2009年第9期30卷 49-52页

作者：孙英会张波于梅芳廖清君张燕文鑫姜偑璐胡晓宁戴宁 Shanghai Institute of Technical Physics Chinese Academy of Sciences

crosstalk of HgCdTe long-wavelength infrared （LWIR） n-on-p diode arrays was measured using scanning laser microscopy. During the measurement, HgCdTe diode arrays with different diode pitches were frontside illuminated by a He-Ne laser at liquid nitrogen temperature and room temperature. The experimental results show that crosstalk between the nearest neighboring diodes decreases exponentially as the diode pitch increases, and the factors that affect the obtained crosstalk are presented and analyzed. crosstalk out of the nominal diode area （optically sensitive area） is also measured and discussed.

关键词： crosstalk HgCdTe n-on-p diode arrays scanning laser microscope

The advantages of crosstalk during the evolution of the BZR1–ARF6–PIF4 (BAP) module∞

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Journal of Integrative Plant Biology 2023年第12期65卷 2631-2644页

作者： Runjie Diao Mengru Zhao Yannan Liu Zhenhua Zhang Bojian Zhong College of Life Sciences Nanjing Normal UniversityNanjing 210023China

The BAP module,comprising BRASSINAZOLE RESISTANT 1(BZR1),AUXIN RESPONSE FACTOR 6(ARF6),and PHYTOCHROME‐INTERACTING FACTOR 4(PIF4),functions as a molecular hub to orchestrate plant growth and development.In Arabidopsis thaliana,components of the BAP module physically interact to form a complex system that integrates light,brassinosteroid(BR),and auxin signals.Little is known about the origin and evolution of the BAP module.Here,we conducted comparative genomic and transcriptomic analyses to investigate the evolution and functional diversification of the BAP module.Our results suggest that the BAP module originated in land plants and that theζ,ε,andγwhole‐genome duplication/triplication events contributed to the expansion of BAP module components in seed plants.Comparative transcriptomic analysis suggested that the prototype BAP module arose in Marchantia polymorpha,experienced stepwise evolution,and became established as a mature regulatory system in seed plants.We developed a formula to calculate the signal transduction productivity of the BAP module and demonstrate that more crosstalk among components enables higher signal transduction efficiency.Our results reveal the evolutionary history of the BAP module and provide insights into the evolution of plant signaling networks and the strategies employed by plants to integrate environmental and endogenous signals.

关键词： BAP module crosstalk origin and evolution signaling networks

The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease

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药物分析学报:英文版 2023年第7期13卷 788-805页

作者： He Li Tianyuan Ye Xingyang Liu Rui Guo Xiuzhao Yang Yangyi Li Dongmei Qi Yihua Wei Yifan Zhu Lei Wen Xiaorui Cheng Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China Xiamen Key Laboratory for TCM Dampness Disease Neurology&Immunology ResearchDepartment of Traditional Chinese MedicineXiang'an HospitalSchool of MedicineXiamen UniversityXiamenFujian361102China Experimental Center Shandong University of Traditional Chinese MedicineJinan250355China

Based on single-cell sequencing of the hippocampi of 5×familiar Alzheimer's disease(5×FAD)and wild type mice at 2-,12-,and 24-month of age,we found an increased percentage of microglia in aging and Alzheimer's disease(AD)mice.Blood brain barrier injury may also have contributed to this increase.Immune regulation by microglia plays a major role in the progression of aging and AD,according to the functions of 41 intersecting differentially expressed genes in microglia.Signaling crosstalk between C−C motif chemokine ligand(CCL)and major histocompatibility complex-1 bridges intercellular communication in the hippocampus during aging and AD.The amyloid precursor protein(APP)and colony stimulating factor(CSF)signals drive 5×FAD to deviate from aging track to AD occurrence among intercellular communication in hippocampus.Microglia are involved in the progression of aging and AD can be divided into 10 functional types.The strength of the interaction among microglial subtypes weakened with aging,and the CCL and CSF signaling pathways were the fundamental bridge of communication among microglial subtypes.

关键词： Alzheimer's disease Microglia Immune crosstalk Chemokine Colony-stimulating factor

An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity

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Signal Transduction and Targeted Therapy 2022年第1期7卷 282-294页

作者： Yanping Wei Xuewu Tang Yibin Ren Yun Yang Fengliang Song Jingbo Fu Shuowu Liu Miao Yu Jing Chen Suyang Wang Kecheng Zhang Yexiong Tan Zhipeng Han Lixjn Wei Baohua Zhang Zhangjun Cheng Liang Li Hongyang Wang International Co-operation Laboratory on Signal Transduction Eastern Hepato-Biliary Surgery InstituteSecond Military Medical UniversityShanghaiChina National Center for Liver Cancer ShanghaiChina Hepato-Pancreato-biliary center Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalShanghaiChina School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Department of Biliary Tract Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghaiChina Tumor Immunology and Gene Therapy Center Eastern Hepato-Biliary Surgery InstituteSecond Military Medical UniversityShanghaiChina National Laboratory for Oncogenes and Related Genes Cancer InstituteRenJi HospitalShanghai Jiao Tong University200441 ShanghaiChina

Hepatocellular carcinoma(HCC)is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy.A new modality of epigenetic regulation has emerged involving RNA-RNA crosstalk networks where two or more competing endogenous RNAs(ceRNAs)bind to the same microRNAs.However,the contribution of such mechanisms in HCC has not been well studied.Herein,potential HMGB1-driven RNA-RNA crosstalk networks were evaluated at different HCC stages,identifying the mT0RC2 component RICTOR as a potential HMGB1 ceRNA in HBV^(+)early stage HCC.Indeed,elevated HMGB1 mRNA was found to promote the expressio n of RICTOR mRNA through competitively bin ding with the miR-200 family,especially miR-429.Functio nal assays emplo ying overexpressi on or in terference strategies dem on strated that the HMGB1 and RICTOR 3zuntra nslated regions(UTR)epigenetically promoted the malignant proliferation,self-renewal,and tumorigenesis in HCC cells.Intriguingly,in terference agai nst HMGB1 and RICTOR in HCC cells promoted a stron ger an ti-PD-L1 immuno therapy resp on se,which appeared to associate with the production of PD-L1^(+)exosomes.Mechanistically,the HMGB1-driven RNA-RNA crosstalk network facilitated HCC cell glutamine metabolism via dual mechanisms,activating a positive feedback loop involving mT0RC2-AKT-C-MYC to upregulate glutamine synthetase(GS)expression,and inducing mTORCI signaling to derepress SIRT4 on glutamate dehydrogenase(GDH).Meanwhile,this crosstalk network could impede the efficacy of immunotherapy through mTORCI-P70S6K dependent PD-L1 production and PD-L1^(+)exosomes activity.In conclusion,our study highlights the non-coding regulatory role of HMGB1 with implicatio ns for RNA-based therapeutic targeting together with a predictio n of an ti-PD-L1 immuno therapy in HCC.

关键词： metabolism network crosstalk