The advantages of crosstalk during the evolution of the BZR1–ARF6–PIF4 (BAP) module∞

作     者：Runjie Diao Mengru Zhao Yannan Liu Zhenhua Zhang Bojian Zhong Runjie Diao;Mengru Zhao;Yannan Liu;Zhenhua Zhang;Bojian Zhong

作者机构：College of Life SciencesNanjing Normal UniversityNanjing 210023China 

出 版 物：《Journal of Integrative Plant Biology》 (植物学报（英文版）)

年 卷 期：2023年第65卷第12期

页      面：2631-2644页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：This study was supported by the National Natural Science FoundationofChina(32122010,31970229,and32100178) the PriorityAcademic Program Development of Jiangsu Higher Education Institutions(PAPD) the Collaborative Innovation Center for Modern Crop Production co-sponsored by Province and Ministry(CIC-MCP). 

主　　题：BAP module crosstalk origin and evolution signaling networks 

摘      要：The BAP module,comprising BRASSINAZOLE RESISTANT 1(BZR1),AUXIN RESPONSE FACTOR 6(ARF6),and PHYTOCHROME‐INTERACTING FACTOR 4(PIF4),functions as a molecular hub to orchestrate plant growth and development.In Arabidopsis thaliana,components of the BAP module physically interact to form a complex system that integrates light,brassinosteroid(BR),and auxin signals.Little is known about the origin and evolution of the BAP module.Here,we conducted comparative genomic and transcriptomic analyses to investigate the evolution and functional diversification of the BAP module.Our results suggest that the BAP module originated in land plants and that theζ,ε,andγwhole‐genome duplication/triplication events contributed to the expansion of BAP module components in seed plants.Comparative transcriptomic analysis suggested that the prototype BAP module arose in Marchantia polymorpha,experienced stepwise evolution,and became established as a mature regulatory system in seed plants.We developed a formula to calculate the signal transduction productivity of the BAP module and demonstrate that more crosstalk among components enables higher signal transduction efficiency.Our results reveal the evolutionary history of the BAP module and provide insights into the evolution of plant signaling networks and the strategies employed by plants to integrate environmental and endogenous signals.