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Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites:In vitro and in vivo studies

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Bioactive Materials 2021年第11期6卷 3999-4013页

作者： Zechuan Zhang Bo Jia Hongtao Yang Yu Han Qiang Wu Kerong Dai Yufeng Zheng School of Materials Science and Engineering Peking UniversityBeijing100871China Department of Orthopedic Surgery Shanghai Key Laboratory of Orthopedic ImplantsShanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai200011China Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China School of Medical Science and Engineering Beihang UniversityBeijing100191China

A novel biodegradable metal system,ZnLiCa ternary alloys,were systematically investigated both in vitro and in *** ultimate tensile strength(UTS)of Zn0.8Li0.1Ca alloy reached 567.60±9.56 MPa,which is comparable to pure Ti,one of the most common material used in *** elongation of Zn0.8Li0.1Ca is 27.82±18.35%,which is the highest among the ZnLiCa *** in vitro degradation rate of Zn0.8Li0.1Ca alloy in simulated body fluid(SBF)showed significant acceleration than that of pure ***-8 tests and hemocompatibility tests manifested that ZnLiCa alloys exhibit good ***-time PCR showed that Zn0.8Li0.1Ca alloy successfully stimulated the expressions of osteogenesis-related genes(ALP,COL-1,OCN and Runx-2),especially the *** in vivo implantation was conducted in the radius of New Zealand rabbits for 24 weeks,aiming to treat the bone *** Micro-CT and histological evaluations proved that the regeneration of bone defect was faster within the Zn0.8Li0.1Ca alloy scaffold than the pure Ti ***0.8Li0.1Ca alloy showed great potential to be applied in orthopedics,especially in the load-bearing sites.

关键词： ZnLiCa alloys Biodegradable metal critical-sized bone defect Orthopedics Porous scaffold In vivo

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Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

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Regenerative Biomaterials 2024年第1期3卷 44-57页

作者： Xi Hua Mingzhuang Hou Lei Deng Nanning Lv Yong Xu Xuesong Zhu Huilin Yang Qin Shi Hao Liu Fan He Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Suzhou Medical CollegeSoochow UniversitySuzhou 215000China Department of Orthopedics Suzhou Wuzhong People’s HospitalSuzhouJiangsu Province 215128China Department of Orthopedic Surgery Lianyungang Clinical College of Xuzhou Medical UniversityLianyungang 222003China

The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone *** challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture ***,the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical support and controlled release of proosteogenic *** this study,a poly(L-lactic acid)(PLLA)/hyaluronic acid(HA)-based nanofibrous membrane was fabricated using the coaxial electrospinning *** incorporation of irisin into the core-shell structure of PLLA/HA nanofibers(PLLA/HA@Irisin)achieved its sustained *** vitro experiments demonstrated that the PLLA/HA@Irisin membranes exhibited favorable *** osteogenic differentiation of bone marrow mesenchymal stem cells(BMMSCs)was improved by PLLA/HA@Irisin,as evidenced by a significant increase in alkaline phosphatase activity and matrix ***,PLLA/HA@Irisin significantly enhanced the mitochondrial function of BMMSCs via the activation of the sirtuin 3 antioxidant *** assess the therapeutic effectiveness,PLLA/HA@Irisin membranes were implanted in situ into critical-sized calvarial defects in *** results at 4 and 8 weeks post-surgery indicated that the implantation of PLLA/HA@Irisin exhibited superior efficacy in promoting vascularized bone formation,as demonstrated by the enhancement of bone matrix synthesis and the development of new blood *** results of our study indicate that the electrospun PLLA/HA@Irisin nanofibers possess characteristics of a biomimetic periosteum,showing potential for effectively treating critical-sized bone defects by improving the mitochondrial function and maintaining redox homeostasis of BMMSCs.

关键词： periosteum irisin mitochondrial function critical-sized bone defect redox homeostasis

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Additively manufactured pure zinc porous scaffolds for critical-sized bone defects of rabbit femur

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Bioactive Materials 2023年第1期19卷 12-23页

作者： Dandan Xia Yu Qin Hui Guo Peng Wen Hong Lin Maximilian Voshage Johannes Henrich Schleifenbaum Yan Cheng Yufeng Zheng Department of Dental Materials Peking University School and Hospital of StomatologyBeijing100081China National Center of Stomatology National Clinical Research Center for Oral DiseasesNational Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing Key Laboratory of Digital StomatologyResearch Center of Engineering and Technology for Digital Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing100081China The State Key Laboratory of Tribology Tsinghua UniversityBeijing100084China Department of Mechanical Engineering Tsinghua UniversityBeijing100084China School of Materials Science and Engineering Peking UniversityBeijing100871China Digital Additive Production(DAP) RWTH Aachen University52074AachenGermany Biomed-X Center Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing100871China

Additive manufacturing has received attention for the fabrication of medical implants that have customized and complicated *** Zn metals are revolutionary materials for orthopedic *** this study,pure Zn porous scaffolds with diamond structures were fabricated using customized laser powder bed fusion(L-PBF)***,the mechanical properties,corrosion behavior,and biocompatibility of the pure Zn porous scaffolds were characterized in *** scaffolds were then implanted into the rabbit femur critical-size bone defect model for 24 *** results showed that the pure Zn porous scaffolds had compressive strength and rigidity comparable to those of cancellous bone,as well as relatively suitable degradation rates for bone regeneration.A benign host response was observed using hematoxylin and eosin(HE)staining of the heart,liver,spleen,lungs,and ***,the pure Zn porous scaffold showed good biocompatibility and osteogenic promotion ability in *** study showed that pure Zn porous scaffolds with customized structures fabricated using L-PBF represent a promising biodegradable solution for treating large bone defects.

关键词： Additive manufacturing Laser powder bed fusion Scaffolds Pure Zn critical-sized bone defect

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