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The role of central nervous system on hypoglycemia and the feasibility of the brain theory in traditional Chinese medicine on treatment of diabetes mellitus

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Journal of Integrative Medicine 2014年第1期12卷 1-6页

作者： Hai-li Jiang Jing-jing Niu Wei-fei Zhang Wen-jin Huang Ming-yue Zhou Wen-jun Sha Jun-yan Li Fu-feng Li Ting Zhu Xin Xia Jun Zhang Yuan-dong Shen Li-gang Zhou Department of Endocrinology Shanghai Pudong HospitalFudan University Pudong Medical Center Department of Endocrinology Shuguang HospitalShanghai University of Traditional Chinese Medicine Diabetes Research Center Shanghai University of Traditional Chinese Medicine Basic Medical Department Shanghai University of Traditional Chinese Medicine Biology and Biological Science Program University of California Department of Gerontology Shuguang HospitalShanghai University of Traditional Chinese Medicine Department of Endocrinology Shanghai East Hospital Department of Police Training Shanghai Police College

The central nervous system （CNS） plays a key regulatory role in glucose homeostasis. In particular, the brain is important in initiating and coordinating protective counterregulatory responses when blood glucose levels fall. This may due to the metabolic dependency of the CNS on glucose, and protection of food supply to the brain. In healthy subjects, blood glucose is normally maintained within a relatively narrow range. Hypoglycemia in diabetic patients can increase the risk of complications, such as heart disease and diabetic peripheral neuropathy. The clinical research finds that the use of traditional Chinese medicine （TCM） has a positive effect on the treatment of hypoglycemia. Here the authors reviewed the current understanding of sensing and counterregulatory responses to hypoglycemia, and discuss combining traditional Chinese and Western medicine and the theory of iatrogenic hypoglycemia in diabetes treatment. Furthermore, the authors clarify the feasibility of treating hypoglycemia on the basis of TCM theory and CNS and have an insight on its clinical practice.

关键词： diabetes mellitus hypoglycemia counterrugulation hormone response neuroendocrine systems hypothalamus brain review

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