The role of central nervous system on hypoglycemia and the feasibility of the brain theory in traditional Chinese medicine on treatment of diabetes mellitus

作     者：Hai-li Jiang Jing-jing Niu Wei-fei Zhang Wen-jin Huang Ming-yue Zhou Wen-jun Sha Jun-yan Li Fu-feng Li Ting Zhu Xin Xia Jun Zhang Yuan-dong Shen Li-gang Zhou 

作者机构：Department of EndocrinologyShanghai Pudong HospitalFudan University Pudong Medical Center Department of EndocrinologyShuguang HospitalShanghai University of Traditional Chinese Medicine Diabetes Research CenterShanghai University of Traditional Chinese Medicine Basic Medical DepartmentShanghai University of Traditional Chinese Medicine Biology and Biological Science ProgramUniversity of California Department of GerontologyShuguang HospitalShanghai University of Traditional Chinese Medicine Department of EndocrinologyShanghai East Hospital Department of Police TrainingShanghai Police College 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2014年第12卷第1期

页      面：1-6页

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：National Natural Science Foundation of China(No. 81370932)to LZ the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning(2009) to LZ the Pujiang Talent Project (PJ2011-0000839) of Shanghai Science and Technology to LZ the Merck Sharp&Dohme Corporation(IISP MISP40313 and MISP40309) to LZ Talents Training Program of Shanghai Pudong Hospital to LZ project of Shanghai University of Traditional Chinese Medicine to LZ 

主　　题：diabetes mellitus hypoglycemia counterrugulation hormone response neuroendocrine systems hypothalamus brain review 

摘      要：The central nervous system （CNS） plays a key regulatory role in glucose homeostasis. In particular, the brain is important in initiating and coordinating protective counterregulatory responses when blood glucose levels fall. This may due to the metabolic dependency of the CNS on glucose, and protection of food supply to the brain. In healthy subjects, blood glucose is normally maintained within a relatively narrow range. Hypoglycemia in diabetic patients can increase the risk of complications, such as heart disease and diabetic peripheral neuropathy. The clinical research finds that the use of traditional Chinese medicine （TCM） has a positive effect on the treatment of hypoglycemia. Here the authors reviewed the current understanding of sensing and counterregulatory responses to hypoglycemia, and discuss combining traditional Chinese and Western medicine and the theory of iatrogenic hypoglycemia in diabetes treatment. Furthermore, the authors clarify the feasibility of treating hypoglycemia on the basis of TCM theory and CNS and have an insight on its clinical practice.